Critical Events in the Toxicity of Redox Active Drugs

[1]  G. Cohen,et al.  Interconversion of NAD(H) to NADP(H). A cellular response to quinone-induced oxidative stress in isolated hepatocytes. , 1989, Biochemical pharmacology.

[2]  G. Cohen,et al.  NAD+ depletion and cytotoxicity in isolated hepatocytes. , 1988, Biochemical pharmacology.

[3]  S. Orrenius,et al.  Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress. , 1988, Toxicology letters.

[4]  D. Hinshaw,et al.  Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. , 1988, The Journal of biological chemistry.

[5]  D. Ross,et al.  Cytotoxicity of the redox cycling compound diquat in isolated hepatocytes: involvement of hydrogen peroxide and transition metals. , 1987, Archives of biochemistry and biophysics.

[6]  J. Musser,et al.  Phospholipase A2: function and pharmacological regulation. , 1987, Biochemical pharmacology.

[7]  G. Cohen,et al.  Free radical mediated cell toxicity by redox cycling chemicals. , 1987, The British journal of cancer. Supplement.

[8]  S. Orrenius,et al.  Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone). , 1987, Biochemical pharmacology.

[9]  S. Orrenius,et al.  Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system. , 1986, The Journal of biological chemistry.

[10]  D. Ross,et al.  Role of redox cycling and lipid peroxidation in bipyridyl herbicide cytotoxicity. Studies with a compromised isolated hepatocyte model system. , 1986, Biochemical pharmacology.

[11]  S. Orrenius,et al.  Menadione (2-methyl-1,4-naphthoquinone)-induced Ca2+ release from rat-liver mitochondria is caused by NAD(P)H oxidation. , 1986, Xenobiotica; the fate of foreign compounds in biological systems.

[12]  R. Jackson,et al.  Production of arachidonic acid metabolites by endothelial cells in hyperoxia. , 1986, Journal of applied physiology.

[13]  L. Sklar,et al.  Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[14]  W. Seeger,et al.  The glutathione redox cycle as a defense system against hydrogen-peroxide-induced prostanoid formation and vasoconstriction in rabbit lungs. , 1986, The American review of respiratory disease.

[15]  D. Hinshaw,et al.  Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. , 1986, The Journal of clinical investigation.

[16]  M. Comporti Lipid peroxidation and cellular damage in toxic liver injury. , 1985, Laboratory investigation; a journal of technical methods and pathology.

[17]  S. Orrenius,et al.  On the role of thiol groups in the inhibition of liver microsomal Ca2+ sequestration by toxic agents. , 1985, Biochemical pharmacology.

[18]  S. Orrenius,et al.  Altered thiol and calcium homeostasis in oxidative hepatocellular injury , 1985, Hepatology.

[19]  S. Orrenius,et al.  Inhibition of hepatocyte plasma membrane Ca2+‐ATPase activity by menadione metabolism and its restoration by thiols , 1985, FEBS letters.

[20]  D. D. Di Monte,et al.  Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. , 1984, Archives of biochemistry and biophysics.

[21]  L. Liu,et al.  Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. , 1984, Science.

[22]  J. Repine,et al.  Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs. , 1984, The Journal of clinical investigation.

[23]  J. Harlan,et al.  Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells. , 1984, The Journal of clinical investigation.

[24]  T. Baillie,et al.  The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro. , 1984, Chemico-biological interactions.

[25]  S. Orrenius,et al.  Critical role of sulfhydryl group(s) in ATP‐dependent Ca2+ sequestration by the plasma membrane fraction from rat liver , 1983, FEBS letters.

[26]  S. Orrenius,et al.  The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells. , 1982, The Journal of biological chemistry.

[27]  R. Traystman,et al.  Oxidant- and lipid-induced pulmonary vasoconstriction mediated by arachidonic acid metabolites. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[28]  A. Ryrfeldt,et al.  Hydroperoxide and cigarette smoke induced effects on lung mechanics and glutathione status in rat isolated perfused and ventilated lungs. , 1988, Life sciences.

[29]  M. Peters-Golden,et al.  Hydrogen-peroxide-induced arachidonic acid metabolism in the rat alveolar macrophage. , 1988, The American review of respiratory disease.

[30]  A. Sciuto,et al.  The role of arachidonate mediators in peroxide-induced lung injury. , 1987, The American review of respiratory disease.

[31]  S. Orrenius,et al.  Interaction of menadione (2-methyl-1,4-naphthoquinone) with glutathione. , 1985, Chemico-biological interactions.