Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes
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Kenji Sugawara | N. Ishihara | T. Ishihara | Wataru Ogawa | Kaori Hozumi | Naotada Ishihara | Takaya Ishihara
[1] W. Ogawa,et al. Canagliflozin ameliorates hepatic fat deposition in obese diabetic mice: Role of prostaglandin E2. , 2021, Biochemical and biophysical research communications.
[2] E. Fontaine,et al. The mechanism by which imeglimin inhibits gluconeogenesis in rat liver cells , 2021, Endocrinology, diabetes & metabolism.
[3] D. Moller,et al. Imeglimin preserves islet β‐cell mass in Type 2 diabetic ZDF rats , 2020, Endocrinology, diabetes & metabolism.
[4] Jing-mei Liu,et al. Comprehensive analysis of partial epithelial mesenchymal transition‐related genes in hepatocellular carcinoma , 2020, Journal of cellular and molecular medicine.
[5] D. Moller,et al. Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action , 2020, bioRxiv.
[6] Subin Kim,et al. A review of phenformin, metformin, and imeglimin , 2020, Drug development research.
[7] S. O’Rahilly,et al. GDF15 mediates the effects of metformin on body weight and energy balance , 2019, Nature.
[8] Amogelang R. Raphenya,et al. Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss , 2019, Nature Metabolism.
[9] F. Wondisford,et al. Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK , 2019, Cell reports.
[10] B. Viollet,et al. Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus , 2019, Nature Reviews Endocrinology.
[11] Shuai Jiang,et al. Mitochondrial electron transport chain, ROS generation and uncoupling (Review) , 2019, International journal of molecular medicine.
[12] E. Fontaine. Metformin-Induced Mitochondrial Complex I Inhibition: Facts, Uncertainties, and Consequences , 2018, Front. Endocrinol..
[13] F. Sicheri,et al. Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase , 2018, Nature Medicine.
[14] Haiyang Xie,et al. Metallothionein 1 family profiling identifies MT1X as a tumor suppressor involved in the progression and metastastatic capacity of hepatocellular carcinoma , 2018, Molecular carcinogenesis.
[15] D. Richardson,et al. Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1. , 2018, Biochimica et biophysica acta. Molecular basis of disease.
[16] M. Birnbaum,et al. Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models , 2018, EBioMedicine.
[17] B. Viollet,et al. AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development , 2018, EBioMedicine.
[18] L. Ford,et al. Repurposing metformin for the prevention of cancer and cancer recurrence , 2017, Diabetologia.
[19] B. Viollet,et al. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. , 2017, Cell metabolism.
[20] K. Petersen,et al. Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents. , 2016, American journal of physiology. Endocrinology and metabolism.
[21] G. Pacini,et al. Imeglimin increases glucose‐dependent insulin secretion and improves β‐cell function in patients with type 2 diabetes , 2015, Diabetes, obesity & metabolism.
[22] F. Wondisford,et al. Metformin action: concentrations matter. , 2015, Cell metabolism.
[23] J. M. Kumar,et al. Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis , 2014, Diabetes.
[24] E. Fontaine,et al. Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model , 2014, Diabetes.
[25] D. Hardie. AMPK--sensing energy while talking to other signaling pathways. , 2014, Cell metabolism.
[26] B. Viollet,et al. Metformin: from mechanisms of action to therapies. , 2014, Cell metabolism.
[27] J. Cha,et al. Metformin Suppresses Lipopolysaccharide (LPS)-induced Inflammatory Response in Murine Macrophages via Activating Transcription Factor-3 (ATF-3) Induction* , 2014, The Journal of Biological Chemistry.
[28] B. Viollet,et al. Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP , 2016 .
[29] H. Lebovitz,et al. Imeglimin, a novel glimin oral antidiabetic, exhibits a good efficacy and safety profile in type 2 diabetic patients , 2012, Diabetes, obesity & metabolism.
[30] B. Viollet,et al. Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status , 2011, Diabetologia.
[31] I. Ben-Sahra,et al. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. , 2011, Cancer research.
[32] X. Leverve,et al. Imeglimin - A New Oral Anti-Diabetic that Targets the Three Key Defects of type 2 Diabetes , 2011 .
[33] B. Viollet,et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. , 2010, The Journal of clinical investigation.
[34] L. Kifle,et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. , 2006, Cell metabolism.
[35] X. Leverve,et al. Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process. , 2005, Diabetes.
[36] J. Turrens,et al. Mitochondrial formation of reactive oxygen species , 2003, The Journal of physiology.
[37] D. Friend,et al. TTTTTTTTT ISOLATED RAT LIVER PARENCHYMAL CELLS A Biochemical and Fine Structural Study , 2003 .
[38] Olle Ljunqvist,et al. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. , 2002, Diabetes.
[39] M. Kasuga,et al. Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes. , 2002, Diabetes.
[40] Margaret S. Wu,et al. Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.
[41] M. Owen,et al. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. , 2000, The Biochemical journal.
[42] M. Rigoulet,et al. Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I* , 2000, The Journal of Biological Chemistry.
[43] C. Bailey,et al. Accumulation of metformin by tissues of the normal and diabetic mouse. , 1994, Xenobiotica; the fate of foreign compounds in biological systems.
[44] D. Friend,et al. HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS , 1969, Journal of Cell Biology.