Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics.

[1]  K. Anderson,et al.  The potential of liposomes in oral drug delivery. , 1998, Critical reviews in therapeutic drug carrier systems.

[2]  Schmidt,et al.  Characterization of M cell development during indomethacin‐induced ileitis in rats , 2000, Alimentary pharmacology & therapeutics.

[3]  C. Choquet,et al.  Freeze-fracture planes of methanogen membranes correlate with the content of tetraether lipids , 1993, Journal of bacteriology.

[4]  B. Hirst,et al.  Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. , 1993, Journal of drug targeting.

[5]  Delie,et al.  Evaluation of nano- and microparticle uptake by the gastrointestinal tract. , 1998, Advanced drug delivery reviews.

[6]  M. Aprahamian,et al.  Transmucosal passage of polyalkylcyanoacrylate nanocapsules as a new drug carrier in the small intestine , 1987, Biology of the cell.

[7]  J. Rhodes,et al.  Peanut ingestion increases rectal proliferation in individuals with mucosal expression of peanut lectin receptor. , 1998, Gastroenterology.

[8]  F. Verzár,et al.  Absorption from the intestine. , 1936 .

[9]  J. S. Trier,et al.  Structure, distribution, and origin of M cells in Peyer's patches of mouse ileum. , 1984, Gastroenterology.

[10]  J. Gordon,et al.  Regional differences in glycoconjugates of intestinal M cells in mice: potential targets for mucosal vaccines. , 1994, The American journal of physiology.

[11]  G. Mayrhofer,et al.  Lymphocyte-filled villi: comparison with other lymphoid aggregations in the mucosa of the human small intestine. , 1998, Gastroenterology.

[12]  Persorbed food particles in the blood of newborns. , 1969, Gynaecologia. International monthly review of obstetrics and gynecology. Revue internationale mensuelle d'obstetrique et de gynecologie. Monatsschrift fur Geburtshilfe und Gynakologie.

[13]  A. Jones,et al.  Epithelial cell specialization within human Peyer's patches: an ultrastructural study of intestinal lymphoid follicles. , 1974, Gastroenterology.

[14]  B. Hirst,et al.  Ulex europaeus 1 lectin targets microspheres to mouse Peyer's patch M-cells in vivo. , 1998, Vaccine.

[15]  C. Sakakura,et al.  Methotrexate bound to carbon particles used for treating cancers with lymph node metastases in animal experiments and a clinical pilot study , 1996, Cancer.

[16]  A T Florence,et al.  Oral uptake and translocation of a polylysine dendrimer with a lipid surface. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[17]  M. E. Lefevre,et al.  Intestinal barrier to large particulates in mice. , 1980, Journal of toxicology and environmental health.

[18]  Ermak,et al.  Microparticle targeting to M cells. , 1998, Advanced drug delivery reviews.

[19]  R. Gurny,et al.  Polymeric nano- and microparticles for the oral delivery of peptides and peptidomimetics. , 1998, Advanced drug delivery reviews.

[20]  A. Florence,et al.  Nanospheres of cyclosporin A: poor oral absorption in dogs. , 1999, International journal of pharmaceutics.

[21]  J. Kraehenbuhl,et al.  Molecular studies of the intestinal mucosal barrier physiopathology using cocultures of epithelial and immune cells: a technical update. , 2000, Microbes and infection.

[22]  Y. Iiboshi,et al.  Role of intestinal mucus on the uptake of latex beads by Peyer's patches and on their transport to mesenteric lymph nodes in rats. , 1999, JPEN. Journal of parenteral and enteral nutrition.

[23]  S. Natsugoe,et al.  Enhanced efficacy of Bleomycin adsorbed on silica particles against lymph node metastasis derived from a transplanted tumor. , 1995, Anticancer research.

[24]  R. Owen.  Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches--a personal and historical perspective. , 1999, Seminars in immunology.

[25]  R. Isberg,et al.  Use of Staphylococcus aureus coated with invasin derivatives to assay invasin function. , 1994, Methods in enzymology.

[26]  R. P. Silver,et al.  Coating the surface: a model for expression of capsular polysialic acid in Escherichia coli K1 , 1996, Molecular microbiology.

[27]  I. Toth,et al.  Novel liposaccharide conjugates for drug and peptide delivery. , 1998, Journal of pharmaceutical sciences.

[28]  A. Gebert,et al.  Kinetics of particle uptake in the domes of Peyer's patches. , 1998, American journal of physiology. Gastrointestinal and liver physiology.

[29]  S. McClugage,et al.  Porosity of the basement membrane overlying Peyer's patches in rats and monkeys. , 1986, Gastroenterology.

[30]  D. Hopwood,et al.  Endocytosis of fluorescent microspheres by human oesophageal epithelial cells: comparison between normal and inflamed tissue. , 1995, Gut.

[31]  R. Löbenberg,et al.  Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[32]  J. Pappo,et al.  Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for M cell uptake. , 1989, Clinical and experimental immunology.

[33]  M. Taussig,et al.  Up-regulation of Microsphere Transport across the Follicle-associated Epithelium of Peyer's Patch by Exposure to Streptococcus Pneumoniae R36a , 2022 .

[34]  J. Pappo,et al.  Monoclonal antibody-directed targeting of fluorescent polystyrene microspheres to Peyer's patch M cells. , 1991, Immunology.

[35]  A. Dayan,et al.  Transepithelial Transport of Large Particles in Rat: a New Model for the Quantitative Study of Particle Uptake , 1998, The Journal of pharmacy and pharmacology.

[36]  Krishnendu Roy,et al.  Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy , 1999, Nature Medicine.

[37]  T. Newby,et al.  Local Immune Responses of the Gut , 1985 .

[38]  T Nagai,et al.  Oral administration of recombinant human erythropoietin in liposomes in rats: influence of lipid composition and size of liposomes on bioavailability. , 1996, Journal of pharmaceutical sciences.

[39]  G. Patel,et al.  Archaeosomes as novel antigen delivery systems. , 1997, FEMS microbiology letters.

[40]  N Hussain,et al.  Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence. , 1995, Journal of drug targeting.

[41]  D. McCarthy,et al.  Further histological evidence of the gastrointestinal absorption of polystyrene nanospheres in the rat , 1992 .

[42]  B. Finlay,et al.  Tyrosine protein kinase inhibitors block invasin-promoted bacterial uptake by epithelial cells , 1992, Infection and immunity.

[43]  A. Dhillon,et al.  Characterisation of inorganic microparticles in pigment cells of human gut associated lymphoid tissue. , 1996, Gut.

[44]  D. Bhalla,et al.  Cytochemical analysis of alkaline phosphatase and esterase activities and of lectin-binding and anionic sites in rat and mouse Peyer's patch M cells. , 1983, The American journal of anatomy.

[45]  K. Anderson,et al.  Folic acid-PEO-labeled liposomes to improve gastrointestinal absorption of encapsulated agents. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[46]  R. Simmons,et al.  Evidence for the phagocytic transport of intestinal particles in dogs and rats , 1988, Infection and immunity.

[47]  A T Florence,et al.  Comparative, quantitative study of lymphoid and non-lymphoid uptake of 60 nm polystyrene particles. , 1994, Journal of drug targeting.

[48]  D. Hopwood,et al.  The ultrastructural localisation of de‐nol (colloidal tripotassium dicitrato‐bismuthate—TDB) in the upper gastrointestinal tract of man and rodents following oral and instrumental administration , 1983, The Journal of pathology.

[49]  P. Lowe,et al.  Calcitonin and Insulin in Isobutylcyanoacrylate Nanocapsules: Protection Against Proteases and Effect on Intestinal Absorption in Rats , 1994, The Journal of pharmacy and pharmacology.

[50]  R. Löbenberg,et al.  Uptake of PMMA nanoparticles from the gastrointestinal tract after oral administration to rats: modification of the body distribution after suspension in surfactant solutions and in oil vehicles , 1999 .

[51]  S. Michalek,et al.  Ultrastructural study of liposome uptake by M cells of rat Peyer's patch: an oral vaccine system for delivery of purified antigen. , 1990, Regional immunology.

[52]  P. Couvreur,et al.  The Effect of Site of Administration in the Gastrointestinal Tract on the Absorption of Insulin from Nanocapsules in Diabetic Rats , 1991, The Journal of pharmacy and pharmacology.

[53]  S. Yamashita,et al.  Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin. , 1999, Journal of pharmaceutical sciences.

[54]  T. Nagai,et al.  Dipalmitoylphosphatidylcholine liposomes with soybean-derived sterols and cholesterol as a carrier for the oral administration of insulin in rats. , 1996, Biological & pharmaceutical bulletin.

[55]  T. Kissel,et al.  Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[56]  D. Scherman,et al.  High lipophilicity decreases drug transport across intestinal epithelial cells. , 1994, The Journal of pharmacology and experimental therapeutics.

[57]  S. Falkow,et al.  Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells , 1987, Cell.

[58]  G. Russell-Jones,et al.  Lectin-mediated transport of nanoparticles across Caco-2 and OK cells. , 1999, International journal of pharmaceutics.

[59]  G. Mayrhofer,et al.  The distribution, ontogeny and origin in the rat of Ia‐positive cells with dendritic morphology and of Ia antigen in epithelia, with special reference to the intestine , 1983, European journal of immunology.

[60]  O'Hagan Dt,et al.  THE INTESTINAL UPTAKE OF PARTICLES AND THE IMPLICATIONS FOR DRUG AND ANTIGEN DELIVERY , 1996 .

[61]  J. Kreuter,et al.  Distribution and elimination of polymethyl methacrylate nanoparticles after peroral administration to rats. , 1984, Journal of pharmaceutical sciences.

[62]  L. Hultén,et al.  Distribution of 169Yb microspheres and colloidal 198Au following injection into the rectal submucosa in dogs. , 1977, Acta radiologica: therapy, physics, biology.

[63]  David J Brayden,et al.  Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia. , 1998, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[64]  R. Whitehead.  Mucosal biopsy of the gastrointestinal tract. , 1973, Major problems in pathology.

[65]  L. Leak.  Electron microscopic observations on lymphatic capillaries and the structural components of the connective tissue-lymph interface. , 1970, Microvascular research.

[66]  B. Hirst,et al.  Targeting to intestinal M cells. , 1996, Journal of anatomy.

[67]  G. Volkheimer.  Persorption of particles: physiology and pharmacology. , 1977, Advances in pharmacology and chemotherapy.

[68]  C. Baquey,et al.  Study of in vitro and in vivo stability of liposomes loaded with calcitonin or indium in the gastrointestinal tract. , 1993, Life sciences.

[69]  M. E. Lefevre,et al.  Intestinal Uptake of Fluorescent Microspheres in Young and Aged Mice 1 , 1989, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[70]  K. Takada,et al.  Intestinal absorption of carboxyfluorescein entrapped in liposomes in comparison with its administration with lipid-surfactant mixed micelles. , 1984, Journal of pharmacobio-dynamics.

[71]  V. Jaitely,et al.  Synthesis and characterisation of palymitoyl propanolol hydrochloride auto-lymphotrophs for oral administration. , 1999, International journal of pharmaceutics.

[72]  E. Campo,et al.  Lectin binding patterns in normal and neoplastic colonic mucosa , 1988, Diseases of the colon and rectum.

[73]  T. Nagai,et al.  Studies on the cyclosporin A loaded stearic acid nanoparticles. , 2000, International journal of pharmaceutics.

[74]  P. Brubaker,et al.  Oral delivery of glucagon-like peptide-1 in a modified polymer preparation normalizes basal glycaemia in diabetic db/db mice , 2000, Diabetologia.

[75]  K. Ikuta,et al.  Progenitors Deve lop , 2003 .

[76]  R Weltzin,et al.  Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting , 1996, The Journal of experimental medicine.

[77]  P. Mangeat,et al.  Mucin-Related Epitopes Distinguish M Cells and Enterocytes in Rabbit Appendix and Peyer’s Patches , 1999, Infection and Immunity.

[78]  A. Sjölander,et al.  Uptake and adjuvant activity of orally delivered saponin and ISCOM vaccines. , 1998, Advanced drug delivery reviews.

[79]  S. Muranishi,et al.  Studies on the promoting effect of lipid-surfactant mixed micelles (MM) on intestinal absorption of colloidal particles. Dependence on particle size and administration site. , 1987, Journal of pharmacobio-dynamics.

[80]  R. Isberg,et al.  The mechanism of phagocytic uptake promoted by invasin-integrin interaction. , 1995, Trends in cell biology.

[81]  G. Patel,et al.  In vitro assessment of archaeosome stability for developing oral delivery systems. , 2000, International journal of pharmaceutics.

[82]  P. James,et al.  M cell numbers increase after transfer of SPF mice to a normal animal house environment. , 1987, The American journal of pathology.

[83]  N. Das,et al.  Oral application of insulin encapsulated liposomes. , 1988, Biochemistry international.

[84]  J. Seifert,et al.  Intestinal absorption of macromolecules and small particles. , 1990, Digestive diseases.

[85]  J. Kopeček,et al.  Biorecognition of HPMA copolymer-lectin conjugates as an indicator of differentiation of cell-surface glycoproteins in development, maturation, and diseases of human and rodent gastrointestinal tissues. , 2000, Journal of biomedical materials research.

[86]  G. Wilson,et al.  Proteolytic processing of reovirus is required for adherence to intestinal M cells , 1994, Journal of virology.

[87]  J. Poupaert,et al.  Poly(diethyl methylidenemalonate) nanoparticles as a potential drug carrier: preparation, distribution and elimination after intravenous and peroral administration to mice. , 1991, Journal of pharmaceutical sciences.

[88]  P. Ogra.  Handbook of mucosal immunology , 1994 .

[89]  S. Miura,et al.  In vivo visualization of lymphatic microvessels and lymphocyte migration through rat Peyer's patches. , 1994, Gastroenterology.

[90]  A. Florence,et al.  Studies on the uptake of tomato lectin nanoparticles in everted gut sacs. , 1999, International journal of pharmaceutics.

[91]  K. Kataoka,et al.  The association of gap junctions with large particles in the crypt epithelium of the rat small intestine. , 1989, Archives of histology and cytology.

[92]  W. Rubas,et al.  Incorporation of the reovirus M cell attachment protein into small unilamellar vesicles: incorporation efficiency and binding capability to L929 cells in vitro. , 1990, Journal of microencapsulation.

[93]  J Maas,et al.  Improved body distribution of 14C-labelled AZT bound to nanoparticles in rats determined by radioluminography. , 1998, Journal of drug targeting.

[94]  M. E. Lefevre,et al.  Intestinal absorption of particulate matter. , 1977, Life sciences.

[95]  G. Volkheimer.  HEMATOGENOUS DISSEMINATION OF INGESTED POLYVINYL CHLORIDE PARTICLES , 1975, Annals of the New York Academy of Sciences.

[96]  W Wackernagel,et al.  Adsorption of plasmid DNA to mineral surfaces and protection against DNase I , 1991, Applied and environmental microbiology.

[97]  V. Reuter,et al.  Peanut lectin-binding sites in polyps of the colon and rectum. Adenomas, hyperplastic polyps, and adenomas with in situ carcinoma. , 1983, Laboratory investigation; a journal of technical methods and pathology.

[98]  C. Ashworth,et al.  A study of particulate intestinal absorption and hepatocellular uptake. Use of polystyrene latex particles. , 1961, Experimental cell research.

[99]  Maia Simionescu,et al.  MORPHOMETRIC DATA ON THE ENDOTHELIUM OF BLOOD CAPILLARIES , 1974, The Journal of cell biology.

[100]  A. Dayan,et al.  Intestinal Uptake of Particulate Material by Dexamethasonetreated Rats: Use of a Novel Technique to Avoid Intestinal Mucosal Contamination , 1998, The Journal of pharmacy and pharmacology.

[101]  D. Cremaschi,et al.  Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle‐associated M cells , 1992, Experimental physiology.

[102]  J. Eldridge,et al.  Vaccine-containing biodegradable microspheres specifically enter the gut-associated lymphoid tissue following oral administration and induce a disseminated mucosal immune response. , 1989, Advances in experimental medicine and biology.

[103]  M. Ercan,et al.  99mTc-labelled monodisperse latex particles coated with amino or carboxyl groups for studies of GI function. , 1993, Journal of microencapsulation.

[104]  A. Lindenau,et al.  Persorption of metallic iron particles. , 1969, Gut.

[105]  E. R. Clark.  GROWTH AND DEVELOPMENT OF FUNCTION IN BLOOD VESSELS AND LYMPHATICS , 1936 .

[106]  P. Vierling,et al.  Membrane permeability and stability in buffer and in human serum of fluorinated di-O-alkylglycerophosphocholine-based liposomes. , 1996, Biochimica et biophysica acta.

[107]  W. Rubas,et al.  Gastrointestinal lymphatic absorption of peptides and proteins , 1991 .

[108]  D. McCarthy,et al.  Nanosphere and microsphere uptake via Peyer's patches: observation of the rate of uptake in the rat after a single oral dose , 1992 .

[109]  L. Szentkuti,et al.  Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon , 1997 .

[110]  R. P. Thompson,et al.  Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease. , 2000, Journal of autoimmunity.

[111]  K. Carr,et al.  Gastrointestinal uptake and translocation of microparticles in the streptozotocin-diabetic rat. , 1996, Journal of anatomy.

[112]  G W Halbert,et al.  The Uptake and Translocation of Latex Nanospheres and Microspheres after Oral Administration to Rats , 1989, The Journal of pharmacy and pharmacology.

[113]  K. Brown,et al.  Aqueous-based microcapsules are detected primarily in gut-associated dendritic cells after oral inoculation of mice. , 1997, Vaccine.

[114]  D. O'hagan,et al.  Intestinal translocation of particulates — implications for drug and antigen delivery , 1990 .

[115]  M. Regoli,et al.  MODIFICATIONS OF THE FOLLICLE‐ASSOCIATED EPITHELIUM BY SHORT‐TERM EXPOSURE TO A NON‐INTESTINAL BACTERIUM , 1996, The Journal of pathology.

[116]  S. Ueda,et al.  Uptake of orally administered polystyrene latex and poly(D,L-lactic/glycolic acid) microspheres into intestinal lymphoid tissues in chickens. , 1999, Veterinary immunology and immunopathology.

[117]  A. Gebert,et al.  M cells in Peyer's patches of the intestine. , 1996, International review of cytology.

[118]  J. Robinson,et al.  Effect of volume and viscosity of coadministered fluid on gastrointestinal distribution of small particles , 1995 .

[119]  Simon C Watkins,et al.  Role of intestinal mucus in transepithelial passage of bacteria across the intact ileum in vitro. , 1994, Surgery.

[120]  E. Pretzer,et al.  Inhibition of human immunodeficiency virus type-1 replication in macrophages and H9 cells by free or liposome-encapsulated L-689,502, an inhibitor of the viral protease. , 1997, Antiviral research.

[121]  J. Kraehenbuhl,et al.  Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria. , 1997, Science.

[122]  A. Florence,et al.  Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency , 1990, The Journal of pharmacy and pharmacology.

[123]  Alexander T. Florence,et al.  Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration , 1994 .

[124]  J. Benoit,et al.  Fate of [14C]poly(DL-lactide-co-glycolide) nanoparticles after intravenous and oral administration to mice , 1994 .

[125]  S. Falkow,et al.  Salmonella typhimurium induces membrane ruffling by a growth factor-receptor-independent mechanism. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[126]  T. Ermak,et al.  Ultrastructural and cytoarchitectural features of lymphoreticular organs in the colon and rectum of adult BALB/c mice. , 1991, The American journal of anatomy.

[127]  C. Lehr,et al.  Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract. , 1994, Critical reviews in therapeutic drug carrier systems.

[128]  H. Patel,et al.  Intracellular digestion of saturated and unsaturated phospholipid liposomes by mucosal cells. Possible mechanism of transport of liposomally entrapped macromolecules across the isolated vascularly perfused rabbit ileum. , 1985, Biochimica et biophysica acta.

[129]  H. Cottier,et al.  Uptake by enterocytes and subsequent translocation to internal organs, eg, the thymus, of Percoll microspheres administered per os to suckling mice. , 1983, Journal of the Reticuloendothelial Society.

[130]  D. Keljo,et al.  Quantitative determination of macromolecular transport rate across intestinal Peyer's patches. , 1983, The American journal of physiology.

[131]  A. J. Rosner,et al.  Demonstration of M Cells in the Specialized Follicle‐Associated Epithelium Overlying Isolated Lymphoid Follicles in the Gut , 1984, Journal of leukocyte biology.

[132]  R. Berg,et al.  Translocation of Certain Indigenous Bacteria from the Gastrointestinal Tract to the Mesenteric Lymph Nodes and Other Organs in a Gnotobiotic Mouse Model , 1979, Infection and immunity.

[133]  C. Price,et al.  Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor. , 1998, Journal of pharmaceutical sciences.

[134]  C. McInnes,et al.  Microsphere formation in a series of derivatized alpha-amino acids: properties, molecular modeling, and oral delivery of salmon calcitonin. , 1995, Journal of medicinal chemistry.

[135]  J. Woodley.  Lectins for gastrointestinal targeting--15 years on. , 2000, Journal of drug targeting.

[136]  J Böckmann,et al.  [Blood titanium levels before and after oral administration titanium dioxide]. , 2000, Die Pharmazie.

[137]  B. Freedman.  Persorption of raw starch: a cause of senile dementia? , 1991, Medical hypotheses.

[138]  D. Lewis,et al.  The Transfer of Polystyrene Microspheres from the Gastrointestinal Tract to the Circulation after Oral Administration in the Rat , 1995, The Journal of pharmacy and pharmacology.

[139]  P. Artursson,et al.  Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junctions. , 1995, Journal of drug targeting.

[140]  YoughW. Cho,et al.  ORAL DELIVERY OF INSULIN , 1989, The Lancet.

[141]  P. James,et al.  Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue. , 1991, The American journal of pathology.

[142]  S. Lowden,et al.  Ileal Peyer's patches in pigs: Intercellular and lymphatic pathways , 1994, The Anatomical record.