Guided-mode resonance sensors for rapid medical diagnostic testing applications

A new tag-free photonic resonance concept occurring on subwavelength waveguide gratings is applied for rapid medical testing applications. These high-resolution sensors operate in real time while being sensitive to a wide variety of analytes, including microbials. This method does not require extensive processing steps, thus simplifying assay tests and enabling a rapid response (less than 30 minutes is possible). In this work, a sensor system that uses a single, fixed-wavelength source with a shaped input wavefront to auto-scan in angle has been developed. As binding events occur at the sensor surface, shifts in a resonance reflection peak (or a corresponding transmission minimum) are tracked as a function of incident angle. The amount of angular shift is correlated to the quantity of analyte in the test sample. Due to inherent polarization diversity, two narrow peaks shift their positions on the sensor surface when a bioreaction occurs, thereby providing cross-referenced data. The sensor system connects to portable interfaces for data acquisition and analysis by dedicated software codes. A portable guided-mode resonance sensor system prototype has been developed. Its performance for the detection of the microbial S. aureus in buffer and rat serum is presented in this paper.

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