Topography of Auditory and Visual P300 in Normal Adults

Auditory and visual P300 recordings were performed on 40 normal, right-handed individuals from age 16 through 65, using 31 evenly spaced scalp electrodes. Amplitude at the P300 peak and latency to this peak at each electrode site were measured. Age was significantly correlated with the 31-electrode mean for auditory and visual P300 amplitudes and auditory and visual P300 latencies. The younger age group (16-40) had shorter auditory and visual P300 latencies than the older group (41-65). Visual P300 amplitudes were of an overall larger magnitude than auditory P300 amplitudes. There were no other differences in P300 amplitudes or latencies by gender, modality, or side of scalp, and no significant topographical differences in P300 amplitudes or latencies by gender, age-group, modality, or side of scalp. Radial current density maps on group-averaged auditory and visual P300 waveforms at the group mean P300 latency at Cz, showed a right centroparietal sink surrounded by sources. This suggests a major right centroparietal P300 generator. Except for the change in P300 amplitudes with age, and the direction of the change in P300 latencies with age, these data on adults are similar to our previous description of P300 topography in normal children. Description of the normal topography of the P300, and demonstration of the lack of topographic differences by gender, age group, modality, or side of scalp, may facilitate the meaningful examination of P300 topography in cognitive disorders. Such an examination might lead to better diagnostic tools and more appropriate treatment of cognitive disorders in adults.

[1]  L. Kaufman,et al.  The hippocampal formation as a source of the slow endogenous potentials. , 1983, Electroencephalography and clinical neurophysiology.

[2]  E. Halgren,et al.  The intracranial topography of the P3 event-related potential elicited during auditory oddball. , 1990, Electroencephalography and clinical neurophysiology.

[3]  Frank H. Duffy,et al.  P300 in schizophrenia: Confirmation and statistical validation of temporal region deficit in P300 topography , 1988, Biological Psychiatry.

[4]  R. Sangal,et al.  P300 Latency: Abnormal in Sleep Apnea with Somnolence and Idiopathic Hypersomnia, but Normal in Narcolepsy , 1995, Clinical EEG.

[5]  P L Nunez,et al.  The Spline‐Laplacian in Clinical Neurophysiology: A Method to Improve EEG Spatial Resolution , 1991, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[6]  K. Squires,et al.  Long latency event-related components of the auditory evoked potential in dementia. , 1978, Brain : a journal of neurology.

[7]  K. Squires,et al.  Age-related variations in evoked potentials to auditory stimuli in normal human subjects. , 1978, Electroencephalography and clinical neurophysiology.

[8]  M I Posner,et al.  Topography of the N400: brain electrical activity reflecting semantic expectancy. , 1993, Electroencephalography and clinical neurophysiology.

[9]  P. Holcomb,et al.  The effects of aging on the P3 component of the visual event-related potential. , 1985, Electroencephalography and clinical neurophysiology.

[10]  F E Bloom,et al.  P300 latency reflects the degree of cognitive decline in dementing illness. , 1986, Electroencephalography and clinical neurophysiology.

[11]  R. Sangal,et al.  Closed head injury patients with mild cognitive complaints without neurological or psychiatric findings have abnormal visual P300 latencies , 1996, Biological Psychiatry.

[12]  T W Picton,et al.  The P300 Wave of the Human Event‐Related Potential , 1992, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[13]  E. Courchesne,et al.  Stimulus novelty, task relevance and the visual evoked potential in man. , 1975, Electroencephalography and clinical neurophysiology.

[14]  J. Rohrbaugh,et al.  Improving spatial and temporal resolution in evoked EEG responses using surface Laplacians. , 1993, Electroencephalography and clinical neurophysiology.

[15]  R Broughton,et al.  A comparison of multiple and single sleep latency and cerebral evoked potential (P300) measures in the assessment of excessive daytime sleepiness in narcolepsy-cataplexy. , 1988, Sleep.

[16]  N. Squires,et al.  Auditory event-related potentials and brain dysfunction in sleep apnea. , 1989, Electroencephalography and clinical neurophysiology.

[17]  R. Sangal,et al.  Topography of Auditory and Visual P300 in Normal Children , 1996, Clinical EEG.

[18]  R. Verleger.  Event-related potentials and cognition: A critique of the context updating hypothesis and an alternative interpretation of P3 , 1988, Behavioral and Brain Sciences.

[19]  A. Papanicolaou,et al.  Magnetoencephalography reveals two distinct sources associated with late positive evoked potentials during visual oddball task. , 1993, Cerebral cortex.