β-cell regeneration: Neogenesis, replication or both?

[1]  C. Muller,et al.  An immunocytochemical profile of the endocrine pancreas using an occlusive duct ligation model. , 2016, JOP : Journal of the pancreas.

[2]  K. Brennand,et al.  Correction: All ß Cells Contribute Equally to Islet Growth and Maintenance , 2007, PLoS Biology.

[3]  M. McCarthy,et al.  Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes , 2007, Science.

[4]  K. Brennand,et al.  All β Cells Contribute Equally to Islet Growth and Maintenance , 2007, PLoS biology.

[5]  J. Kushner,et al.  Growth and regeneration of adult beta cells does not involve specialized progenitors. , 2007, Developmental cell.

[6]  M. Brendel,et al.  Glucose-dependent expansion of pancreatic beta-cells by the protein p8 in vitro and in vivo. , 2007, American journal of physiology. Endocrinology and metabolism.

[7]  A. Attie,et al.  The genetic landscape of type 2 diabetes in mice. , 2007, Endocrine reviews.

[8]  Daniel J. Barker,et al.  Differential Effects of p27 in Regulation of β-Cell Mass During Development, Neonatal Period, and Adult Life , 2006, Diabetes.

[9]  A. F. Stewart,et al.  The Cell Cycle Inhibitory Protein p21cip Is Not Essential for Maintaining β-Cell Cycle Arrest or β-Cell Function In Vivo , 2006, Diabetes.

[10]  K. Ligon,et al.  p16INK4a induces an age-dependent decline in islet regenerative potential , 2006, Nature.

[11]  R. Rizza,et al.  Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans , 2006, Diabetologia.

[12]  Kathrin Maedler,et al.  Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1. , 2006, Diabetes.

[13]  M. Brendel,et al.  Glucose-dependent expansion of pancreatic β-cells by the protein p8 in vitro and in vivo , 2006 .

[14]  P. Butler,et al.  Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes , 2006, Diabetologia.

[15]  X. Hua,et al.  Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. , 2006, Cancer research.

[16]  S. Bonner-Weir,et al.  Timing and expression pattern of carbonic anhydrase II in pancreas , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[17]  A. F. Stewart,et al.  Molecular Control of Cell Cycle Progression in the Pancreatic β-Cell , 2006 .

[18]  I. Cózar-Castellano,et al.  Growth factors and beta cell replication. , 2006, The international journal of biochemistry & cell biology.

[19]  S. Bonner-Weir,et al.  Are there pancreatic progenitor cells from which new islets form after birth? , 2006, Nature Clinical Practice Endocrinology &Metabolism.

[20]  M. Barcová,et al.  Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas , 2006, Nature Medicine.

[21]  O. Rozenblatt-Rosen,et al.  Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[22]  R. Rizza,et al.  Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? , 2005, Diabetologia.

[23]  R. Scharfmann,et al.  Ex vivo analysis of acinar and endocrine cell development in the human embryonic pancreas , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[24]  J. Kushner,et al.  Very Slow Turnover of β-Cells in Aged Adult Mice , 2005 .

[25]  S. Leach,et al.  Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates , 2005, Development.

[26]  N. Fausto,et al.  Mechanisms of liver regeneration and their clinical implications. , 2005, Journal of hepato-biliary-pancreatic surgery.

[27]  Y. Kido,et al.  Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice , 2005, Nature Medicine.

[28]  O. Rozenblatt-Rosen,et al.  Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[29]  B. Raaka,et al.  Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells , 2004, Science.

[30]  T. Aye,et al.  The pancreatic ductal epithelium serves as a potential pool of progenitor cells , 2004, Pediatric diabetes.

[31]  M. Mercola,et al.  No pancreatic endocrine stem cells? , 2004, The New England journal of medicine.

[32]  Irving L Weissman,et al.  Biology of hematopoietic stem cells and progenitors: implications for clinical application. , 2003, Annual review of immunology.

[33]  Yuichi Sato,et al.  The expression of pancreatic endocrine markers in centroacinar cells of the normal and regenerating rat pancreas: their possible transformation to endocrine cells. , 2003, Archives of histology and cytology.

[34]  Zhao-Qi Wang,et al.  Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. , 2003, Cancer research.

[35]  J. Tuomilehto,et al.  Age, body mass index and Type 2 diabetes-associations modified by ethnicity. , 2003, Diabetologia.

[36]  K. Mutoh,et al.  Centroacinar and intercalated duct cells as potential precursors of pancreatic endocrine cells in rats treated with streptozotocin. , 2003, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

[37]  V. Lefebvre,et al.  Formation of insulin-positive cells in implants of human pancreatic duct cell preparations from young donors , 2003, Diabetologia.

[38]  L. Weber,et al.  Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model , 2003, Critical reviews in toxicology.

[39]  Robert A. Rizza,et al.  β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes , 2003, Diabetes.

[40]  S. Tågerud,et al.  Pharmacological treatment of chronic diabetes by stimulating pancreatic beta-cell regeneration with systemic co-administration of EGF and gastrin. , 2002, Pharmacology & toxicology.

[41]  O. Madsen,et al.  Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3 , 2002, The Journal of cell biology.

[42]  A. F. Stewart,et al.  Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro. , 2002, Diabetes.

[43]  B. Tyrberg,et al.  c-Myc controls proliferation versus differentiation in human pancreatic endocrine cells. , 2002, The Journal of clinical endocrinology and metabolism.

[44]  B. Portha,et al.  Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4. , 2002, Diabetes.

[45]  M. Stoffel,et al.  Molecular etiologies of mody and other early-onset forms of diabetes , 2002, Current diabetes reports.

[46]  Caiying Guo,et al.  A cre recombinase transgene with mosaic, widespread tamoxifen‐inducible action , 2002, Genesis.

[47]  B. Glaser,et al.  p57(KIP2) expression in normal islet cells and in hyperinsulinism of infancy. , 2001, Diabetes.

[48]  A. F. Stewart,et al.  Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. , 2001, Diabetes.

[49]  I. Nasir,et al.  Regeneration of Pancreatic β Cells from Intra-Islet Precursor Cells in an Experimental Model of Diabetes. , 2001, Endocrinology.

[50]  G. Yeoh,et al.  A modified choline‐deficient, ethionine‐supplemented diet protocol effectively induces oval cells in mouse liver , 2001, Hepatology.

[51]  L. Borg,et al.  Species differences in susceptibility of transplanted and cultured pancreatic islets to the beta-cell toxin alloxan. , 2001, General and comparative endocrinology.

[52]  G. Steil,et al.  Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression. , 2001, American journal of physiology. Endocrinology and metabolism.

[53]  K. Zaret,et al.  A bipotential precursor population for pancreas and liver within the embryonic endoderm. , 2001, Development.

[54]  J. Habener,et al.  Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. , 2001, Diabetes.

[55]  B. Tyrberg,et al.  β-Cell Differentiation from a Human Pancreatic Cell Line in Vitro and in Vivo , 2001 .

[56]  S. Bonner-Weir,et al.  In vitro cultivation of human islets from expanded ductal tissue. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[57]  F. Levine,et al.  Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. , 2000, The Journal of endocrinology.

[58]  F. Levine,et al.  PDX-1 and cell-cell contact act in synergy to promote delta-cell development in a human pancreatic endocrine precursor cell line. , 2000, Molecular endocrinology.

[59]  L. Bouwens,et al.  Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1. , 2000, Diabetes.

[60]  A. F. Stewart,et al.  Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia* , 2000, The Journal of Biological Chemistry.

[61]  S. Bonner-Weir,et al.  Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. , 1999, Diabetes.

[62]  N. Sarvetnick,et al.  Transgenic expression of epidermal growth factor and keratinocyte growth factor in beta-cells results in substantial morphological changes. , 1999, The Journal of endocrinology.

[63]  James M. Roberts,et al.  CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.

[64]  Ana D. Lopez,et al.  Sustained proliferation of PDX-1+ cells derived from human islets. , 1999, Diabetes.

[65]  M. Barbacid,et al.  Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia , 1999, Nature Genetics.

[66]  T. Kafri,et al.  Gene transfer to human pancreatic endocrine cells using viral vectors. , 1999, Diabetes.

[67]  James M. Roberts,et al.  The p21Cip1 and p27Kip1 CDK ‘inhibitors’ are essential activators of cyclin D‐dependent kinases in murine fibroblasts , 1999, The EMBO journal.

[68]  G. Leibowitz,et al.  Telomerase Activity Is Sufficient To Allow Transformed Cells To Escape from Crisis , 1999, Molecular and Cellular Biology.

[69]  M. Reth,et al.  Comparison of the Tamoxifen Regulated Chimeric Cre Recombinases MerCreMer and CreMer , 1999, Biological chemistry.

[70]  L. Rosenberg Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model , 1998, Microscopy research and technique.

[71]  F. Levine Gene therapy for diabetes: strategies for β‐cell modification and replacement , 1997 .

[72]  E. Bertelli,et al.  Intermediate endocrine-acinar pancreatic cells in duct ligation conditions. , 1997, American journal of physiology. Cell physiology.

[73]  N. Sarvetnick,et al.  Endocrine/Exocrine Intermediate Cells in Streptozotocin‐Treated Ins‐IFN‐γ Transgenic Mice , 1997 .

[74]  R. Sorenson,et al.  Adaptation of Islets of Langerhans to Pregnancy: β-Cell Growth, Enhanced Insulin Secretion and the Role of Lactogenic Hormones , 1997, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[75]  S. Elledge,et al.  Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome , 1997, Nature.

[76]  F. Pattou,et al.  Ductal Cyst Formation in Collagen-Embedded Adult Human Islet Preparations: A Means to the Reproduction of Nesidioblastosis In Vitro , 1996, Diabetes.

[77]  Ana D. Lopez,et al.  Growth Factor/Matrix-Induced Proliferation of Human Adult β-Cells , 1995, Diabetes.

[78]  L. Rosenberg,et al.  In vivo cell transformation: neogenesis of beta cells from pancreatic ductal cells. , 1995, Cell transplantation.

[79]  S. Bonner-Weir,et al.  Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model , 1995, Diabetes.

[80]  F. Levine,et al.  Acid beta-galactosidase: a developmentally regulated marker of endocrine cell precursors in the human fetal pancreas. , 1994, The Journal of clinical endocrinology and metabolism.

[81]  J. Parsons,et al.  Regulation of Islet β-Cell Proliferation by Prolactin in Rat Islets , 1994, Diabetes.

[82]  L. Baxter,et al.  A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development , 1993, Diabetes.

[83]  N. Sarvetnick,et al.  Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. , 1993, Development.

[84]  J. Lemire,et al.  Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine. , 1991, The American journal of pathology.

[85]  L. Harrison,et al.  Pancreatic Beta Cell Proliferation in Rabbits Demonstrated by Bromodeoxyuridine Labeling , 1989, Pancreas.

[86]  S. Thorgeirsson,et al.  In vivo differentiation of rat liver oval cells into hepatocytes. , 1989, Cancer research.

[87]  S. Thorgeirsson,et al.  A precursor-product relationship exists between oval cells and hepatocytes in rat liver. , 1987, Carcinogenesis.

[88]  D. Hanahan,et al.  Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. , 1985, Nature.

[89]  M. Rechler,et al.  Growth Hormone Stimulates Islet B-Cell Replication in Neonatal Rat Pancreatic Monolayer Cultures , 1983, Diabetes.

[90]  I. Swenne Effects of Aging on the Regenerative Capacity of the Pancreatic B-Cell of the Rat , 1983, Diabetes.

[91]  K. Hummel,et al.  The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL/KsJ and C57BL/6J strains , 1972, Biochemical Genetics.

[92]  W. Chick,et al.  Studies in the diabetic mutant mouse: I. Light microscopy and radioautography of pancreatic islets , 1970, Diabetologia.

[93]  W. Chick,et al.  Mitotic Division in Pancreatic Beta Cells , 1969, Science.

[94]  J. Logothetopoulos,et al.  Histological and Autoradiographic Studies of the Islets of Mice Injected with Insulin Antibody , 1966, Diabetes.

[95]  A. F. Stewart,et al.  The cell cycle inhibitory protein p21cip is not essential for maintaining beta-cell cycle arrest or beta-cell function in vivo. , 2006, Diabetes.

[96]  A. F. Stewart,et al.  Molecular control of cell cycle progression in the pancreatic beta-cell. , 2006, Endocrine reviews.

[97]  J. Kushner,et al.  Very slow turnover of beta-cells in aged adult mice. , 2005, Diabetes.

[98]  Yuval Dor,et al.  Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. , 2004, Nature.

[99]  I. Rooman,et al.  In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells , 2004, Diabetologia.

[100]  A. F. Stewart,et al.  Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. , 2004, Diabetes.

[101]  G. Korbutt,et al.  Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently. , 2004, The review of diabetic studies : RDS.

[102]  Robert A Rizza,et al.  Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. , 2003, Diabetes.

[103]  I. Rooman,et al.  Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas , 2003, Virchows Archiv.

[104]  Yuichiro Yamada,et al.  Impaired beta-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance. , 2003, Diabetes research and clinical practice.

[105]  Yuichiro Yamada,et al.  Impaired β-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance , 2003 .

[106]  I. Nasir,et al.  Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. , 2001, Endocrinology.

[107]  N. Sarvetnick,et al.  Endocrine/exocrine intermediate cells in streptozotocin-treated Ins-IFN-gamma transgenic mice. , 1997, Pancreas.

[108]  F. Levine Gene therapy for diabetes: strategies for beta-cell modification and replacement. , 1997, Diabetes/metabolism reviews.

[109]  Ana D. Lopez,et al.  Isolation and Characterization of a Cell Line from the Epithelial Cells of the Human Fetal Pancreas , 1997, Cell transplantation.

[110]  J. Rubin,et al.  Growth factor/matrix-induced proliferation of human adult beta-cells. , 1995, Diabetes.

[111]  J. Parsons,et al.  Regulation of islet beta-cell proliferation by prolactin in rat islets. , 1994, Diabetes.

[112]  K. Swann,et al.  Lighting the fuse at fertilization , 1993 .