Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma

[1]  Narasimhan P. Agaram,et al.  A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions , 2018, The American journal of surgical pathology.

[2]  A. Borkhardt,et al.  Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations , 2017, European Journal of Human Genetics.

[3]  J. Sicklick,et al.  Duodenal-Jejunal Flexure GI Stromal Tumor Frequently Heralds Somatic NF1 and Notch Pathway Mutations. , 2017, JCO precision oncology.

[4]  Asha A. Nair,et al.  Gastroblastoma harbors a recurrent somatic MALAT1–GLI1 fusion gene , 2017, Modern Pathology.

[5]  T. Azuma,et al.  Gastric plexiform fibromyxoma resected by endoscopic submucosal dissection after observation of chronological changes: A case report , 2017, World journal of gastrointestinal oncology.

[6]  M. Todaro,et al.  Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma , 2017, Oncogene.

[7]  J. Sicklick,et al.  Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression , 2016, Oncotarget.

[8]  C. Antonescu,et al.  Recurrent MALAT1–GLI1 oncogenic fusion and GLI1 up‐regulation define a subset of plexiform fibromyxoma , 2016, The Journal of pathology.

[9]  A. Carrato,et al.  Unusual focal keratin expression in plexiform angiomyxoid myofibroblastic tumor , 2016, Medicine.

[10]  P. Rao,et al.  Translocation t(7;12) as the sole chromosomal abnormality resulting in ACTB-GLI1 fusion in pediatric gastric pericytoma. , 2016, Human pathology.

[11]  M. Copland,et al.  Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia , 2016, Scientific Reports.

[12]  J. Sicklick,et al.  Image based detection and targeting of therapy resistance in pancreatic adenocarcinoma , 2016, Nature.

[13]  J. Wayne,et al.  Plexiform fibromyxoma with cotyledon-like serosal growth: A case report of a rare gastric tumor and review of the literature. , 2016, Oncology letters.

[14]  S. Neelapu,et al.  Hedgehog inhibitors selectively target cell migration and adhesion of mantle cell lymphoma in bone marrow microenvironment , 2016, Oncotarget.

[15]  Xin-yang Wang,et al.  Non-canonical GLI1/2 activation by PI3K/AKT signaling in renal cell carcinoma: A novel potential therapeutic target. , 2016, Cancer letters.

[16]  P. Stephens,et al.  Evaluation of 122 advanced‐stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies , 2016, Cancer.

[17]  S. Fulda,et al.  Hedgehog Inhibitors in Rhabdomyosarcoma: A Comparison of Four Compounds and Responsiveness of Four Cell Lines , 2015, Front. Oncol..

[18]  N. Warner,et al.  NOD1 and NOD2: signaling, host defense, and inflammatory disease. , 2014, Immunity.

[19]  Alex M. Fichtenholtz,et al.  Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing , 2013, Nature Biotechnology.

[20]  S. Pomeroy,et al.  Hedgehog-GLI pathway in medulloblastoma. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[21]  James R. Anderson,et al.  Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: A report from the Children's Oncology Group , 2011, Pediatric blood & cancer.

[22]  Jeroen F. J. Laros,et al.  LOVD v.2.0: the next generation in gene variant databases , 2011, Human mutation.

[23]  Shuang Pan,et al.  Mechanisms of Inactivation of PTCH1 Gene in Nevoid Basal Cell Carcinoma Syndrome: Modification of the Two-Hit Hypothesis , 2010, Clinical Cancer Research.

[24]  L. Sobin,et al.  Plexiform Fibromyxoma: A Distinctive Benign Gastric Antral Neoplasm Not to be Confused With a Myxoid GIST , 2009, The American journal of surgical pathology.

[25]  A. Stemmer-Rachamimov,et al.  Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells. , 2008, Cancer cell.

[26]  J. Sicklick,et al.  Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. , 2006, Carcinogenesis.

[27]  B. Wainwright,et al.  Patched1 functions as a gatekeeper by promoting cell cycle progression. , 2006, Cancer research.

[28]  B. Wainwright,et al.  Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant‐negative mechanism , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[29]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[30]  M. Rosemann,et al.  Unbalanced overexpression of the mutant allele in murine Patched mutants. , 2002, Carcinogenesis.

[31]  J. Regezi Odontogenic Cysts, Odontogenic Tumors, Fibroosseous, and Giant Cell Lesions of the Jaws , 2002, Modern Pathology.

[32]  R. L. Johnson,et al.  In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration. , 2000, Molecular cell.

[33]  Michael Dean,et al.  Is human patched the gatekeeper of common skin cancers? , 1996, Nature Genetics.

[34]  M. Greene,et al.  Developmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9 , 1992, Cell.