The LDL pathway in human fibroblasts: a receptor-mediated mechanism for the regulation of cholesterol metabolism.

[1]  R. Mahley,et al.  Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts. , 1976, The Journal of biological chemistry.

[2]  T. Carew,et al.  Uptake and degradation of low density lipoprotein by swine arterial smoot muscle cells with inhibition of cholesterol biosynthesis. , 1976, Biochimica et biophysica acta.

[3]  N. Beratis,et al.  Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and the esterification of cholesterol in human long term lymphoid cell lines. , 1976, Biochemistry.

[4]  J. Goldstein,et al.  Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans , 1976, Cell.

[5]  M. Brown,et al.  Receptor-mediated control of cholesterol metabolism. , 1976, Science.

[6]  A. Beaudet,et al.  Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease. , 1975, The Journal of biological chemistry.

[7]  J. Breslow,et al.  Effect of lipoprotein on 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity in rat liver cell culture: special suppressant effect of a lipoprotein isolated from hypercholesterolemic rat plasma. , 1975, Biochemical and biophysical research communications.

[8]  J. Goldstein,et al.  Regulation of the activity of the low density lipoprotein receptor in human fibroblasts , 1975, Cell.

[9]  R. Lees,et al.  Homozygous Familial Hypercholesterolemia , 1975 .

[10]  M. Brown,et al.  Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339. , 1975, The Journal of biological chemistry.

[11]  A. Gotto,et al.  A comparative study on the removal of cellular lipids from Landschütz ascites cells by human plasma apolipoproteins. , 1975, The Journal of biological chemistry.

[12]  O. Stein,et al.  Surface binding and interiorization of homologous and heterologous serum lipoproteins by rat aortic smooth muscle cells in culture. , 1975, Biochimica et biophysica acta.

[13]  R. Mahley,et al.  Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured swine aortic smooth muscle cells by plasma lipoproteins , 1975 .

[14]  M. Brown,et al.  Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[15]  J. Breslow,et al.  Cholesterol, 7-ketocholesterol and 25-hydroxycholesterol uptake studies and effect on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in human fibroblasts. , 1975, Biochimica et biophysica acta.

[16]  R. Mahley,et al.  Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. , 1975, Biochemistry.

[17]  M. Brown,et al.  Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols. , 1975, The Journal of biological chemistry.

[18]  J. Albers,et al.  Lipoprotein uptake by cultured human arterial smooth muscle cells. , 1975, Biochimica et biophysica acta.

[19]  M. Brown,et al.  Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts. , 1975, The Journal of biological chemistry.

[20]  A. Kandutsch,et al.  Regulation of sterol synthesis in cultured cells by oxygenated derivatives of cholesterol , 1975, Journal of cellular physiology.

[21]  M. Brown,et al.  Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells , 1975, Journal of cellular physiology.

[22]  M. Brown,et al.  Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. , 1975, The Journal of clinical investigation.

[23]  A. Fogelman,et al.  Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia. , 1975, The Journal of biological chemistry.

[24]  O. Stein,et al.  Comparative Uptake of Rat and Human Serum Low‐Density and High‐Density Lipoproteins by Rat Aortic Smooth Muscle Cells in Culture , 1975, Circulation research.

[25]  M. Brown,et al.  Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Brown,et al.  Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism. , 1975, The American journal of medicine.

[27]  P. Cuatrecasas,et al.  Membrane receptors as general markers for plasma membrane isolation procedures. The use of 125-I-labeled wheat germ agglutinin, insulin, and cholera toxin. , 1975, The Journal of biological chemistry.

[28]  O. Stein,et al.  The removal of cholesterol from aortic smooth muscle cells in culture and Landschutz ascites cells by fractions of human high-density apolipoprotein. , 1975, Biochimica et biophysica acta.

[29]  M. Brown,et al.  Hyperlipidemia in coronary heart disease: a biochemical genetic approach. , 1975, The Journal of laboratory and clinical medicine.

[30]  M. Brown,et al.  Steroid requirements for suppression of HMG CoA reductase activity in cultured human fibroblasts. , 1975, Advances in experimental medicine and biology.

[31]  R. Steinman,et al.  PINOCYTOSIS IN FIBROBLASTS , 1974, The Journal of cell biology.

[32]  M. Brown,et al.  Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol. , 1974, The Journal of biological chemistry.

[33]  M. Brown,et al.  Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[34]  M. Wibo,et al.  PROTEIN DEGRADATION IN CULTURED CELLS , 1974, The Journal of cell biology.

[35]  J. Watson,et al.  Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in hepatoma tissue culture cells by serum lipoproteins. , 1974, The Journal of biological chemistry.

[36]  A. Kandutsch,et al.  Inhibition of sterol synthesis in cultured mouse cells by cholesterol derivatives oxygenated in the side chain. , 1974, The Journal of biological chemistry.

[37]  P. Tulkens,et al.  Commentary. Lysosomotropic agents. , 1974, Biochemical pharmacology.

[38]  M. Brown,et al.  Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. , 1974, The Journal of biological chemistry.

[39]  G. Rothblat,et al.  Regulation of cellular sterol flux and synthesis by human serum lipoproteins. , 1974, Biochimica et biophysica acta.

[40]  J. Goldstein,et al.  Expression of the Familial Hypercholesterolemia Gene in Heterozygotes: Mechanism for a Dominant Disorder in Man , 1974, Science.

[41]  A. Beaudet,et al.  Acid lipase in cultured fibroblasts: cholesterol ester storage disease. , 1974, The Journal of laboratory and clinical medicine.

[42]  O. Stein,et al.  Lipoprotein Uptake and Metabolism by Rat Aortic Smooth Muscle Cells in Tissue Culture , 1974, Circulation research.

[43]  D. M. Lee,et al.  Composition and concentration of apolipoproteins in very-low-and low-density lipoproteins of normal human plasma. , 1974, Atherosclerosis.

[44]  Joseph L. Goldstein,et al.  Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity , 1974, Proceedings of the National Academy of Sciences.

[45]  M. Brown,et al.  Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. , 1974, The Journal of biological chemistry.

[46]  K. Ak,et al.  Cholesterol synthesis by cultured fibroblasts: decreased feedback inhibition in familial hypercholesterolemia. , 1974 .

[47]  A. Kandutsch,et al.  Inhibition of sterol synthesis in cultured mouse cells by 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol, and 7-ketocholesterol. , 1973, The Journal of biological chemistry.

[48]  Sverre O. Lie,et al.  Inactivation of lysosomal function in normal cultured human fibroblasts by chloroquine. , 1973, Biochemical pharmacology.

[49]  Z. Beg,et al.  Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and wth protein fractions of rat liver cytosol. , 1973, Biochemical and biophysical research communications.

[50]  A. Fogelman,et al.  Control of lipid metabolism in human leukocytes. , 1973, The Journal of biological chemistry.

[51]  M. Brown,et al.  Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[52]  A. Khachadurian,et al.  Experiences with the homozygous cases of familial hypercholesterolemia. A report of 52 patients. , 1973, Nutrition and metabolism.

[53]  M. Brown,et al.  Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[54]  N. Myant,et al.  Type II hyperlipoproteinaemia. , 1973, Clinics in endocrinology and metabolism.

[55]  N. Sharon,et al.  Lectins: cell-agglutinating and sugar-specific proteins. , 1972, Science.

[56]  D. Fredrickson,et al.  Enzyme deficiency in cholesteryl ester storage idisease. , 1972, The Journal of clinical investigation.

[57]  J. Avigan,et al.  In vitro biosynthesis of lipids, proteins and deoxyribonucleic acid in aortic tissue and in culture aortic cells. , 1972, Biochimica et biophysica acta.

[58]  P. Iverius.  The interaction between human plasma lipoproteins and connective tissue glycosaminoglycans. , 1972, The Journal of biological chemistry.

[59]  J. Burke,et al.  Deficient Activity of Hepatic Acid Lipase in Cholesterol Ester Storage Disease , 1972, Science.

[60]  J. Avigan,et al.  In vitro effects of serum proteins and lipids on lipid synthesis in human skin fibroblasts and leukocytes grown in culture. , 1972, Biochimica et biophysica acta.

[61]  D M Crothers,et al.  The influence of polyvalency on the binding properties of antibodies. , 1972, Immunochemistry.

[62]  G. Nelson.  Blood Constituents. (Book Reviews: Blood Lipids and Lipoproteins. Quantitation, Composition, and Metabolism) , 1972 .

[63]  J. Blass,et al.  Regulation of sterol synthesis in human skin fibroblast cultures , 1970 .

[64]  J. Dietschy,et al.  Regulation of cholesterol metabolism. I. , 1970, The New England journal of medicine.

[65]  Marvin D. Siperstein,et al.  Regulation of cholesterol biosynthesis in normal and malignant tissues. , 1970 .

[66]  G. Rothblat.  The effect of serum components on sterol biosynthesis in L cells , 1969, Journal of cellular physiology.

[67]  G. Rothblat,et al.  Lipid metabolism in tissue culture cells. , 1967, Advances in lipid research.

[68]  R. Dean,et al.  Lysosomes in biology and pathology , 1969 .

[69]  A. Tappel,et al.  Lysosomal lipases of rat liver and kidney. , 1968, The Journal of biological chemistry.

[70]  W. Stoffel,et al.  Studies on lipolytic activities of rat liver lysosomes. , 1967, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

[71]  J. M. Bailey,et al.  Lipid Metabolism in Cultured Cells , 1966 .

[72]  E. H. Estes,et al.  Familial hypercholesterolemia: a genetic and metabolic study. , 1966 .

[73]  D. Goodman.  Cholesterol ester metabolism. , 1965, Physiological reviews.

[74]  A. Khachadurian.  THE INHERITANCE OF ESSENTIAL FAMILIAL HYPERCHOLESTEROLEMIA. , 1964, The American journal of medicine.