论文信息 - Hepatocellular carcinoma associated with tight‐junction protein 2 deficiency

Hepatocellular carcinoma associated with tight‐junction protein 2 deficiency

Mutations in TJP2 (also named ZO-2), encoding tight-junction protein 2 (TJP2), cause an autosomal-recessive form of progressive intrahepatic cholestasis.1 Association of TJP2 deficiency with hepatocellular carcinoma (HCC) in childhood has not been recognized.

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[2] Richard J. Thompson,et al. Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency , 2014, Nature Communications.

[3] Colin A. Johnson,et al. Mutations in TJP2 cause progressive cholestatic liver disease , 2014, Nature Genetics.

[4] Erika Garay,et al. Role of tight junctions in cell proliferation and cancer. , 2007, Progress in histochemistry and cytochemistry.

[5] Richard J. Thompson,et al. Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency , 2006, Hepatology.