Experimental and modeling study of catalytic reaction of glucose isomerization: Kinetics and packed‐bed dynamic modeling

The kinetics and equilibrium of isomerization reaction of D-glucose to D-fructose have been investigated using a commercial immobilized glucose isomerase (IGI), Sweetzyme type IT 1 , in a batch stirred-tank reactor. The batch experimental data were used to model the reaction kinetics using the well-known Michaelis–Menten rate expression. The kinetic model was utilized in a dynamic-mathematical model for a packed-bed reactor to predict the concentration profiles of D-glucose and D-fructose within the reactor. The experimental results for the fractional conversion of D-glucose in the packed-bed reactor of IGI catalyst indicated that the model prediction of the transient and steady-state performance of the packed-bed reactor was satisfactory and as such could be used in the design of a fixed-bed IGI catalytic reactor. Moreover, the influences of axial mixing term, particle Re number, and axial peclet number (Pea )o n the performance capability of the packed-bed reactor of IGI catalyst were investigated. 2008 American Institute of Chemical Engineers AIChE J, 54: 1333–1343, 2008

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