Impact of antibiotic allergy and resistance on oral first-line antibiotic treatment choice for recurrent urinary tract infections in older women

Study design, materials and methods Following IRB approval, a prospectively maintained database of women 65 years old and older with documented RUTIs (≥3 UTI/year) and trigonitis on cystoscopy was reviewed for demographic data (age, race, BMI, diabetes, immunosuppression), known drug allergies, blood urea nitrogen (BUN), creatinine, estimated GFR, and antibiotic susceptibility. Data was acquired through an electronic medical record (EPIC) by a reviewer (YW) not involved in patient care, with all values taken from the most recent available test results. Women with no antibiotic susceptibility profiles available for review were excluded. Three commonly used antibiotics for the management of RUTIs were further analyzed: trimethoprim-sulfamethoxazole (TMP-SMX) and other sulfonamides, fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin), and nitrofurantoin.