Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells

[1]  K. Miyazono,et al.  Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer. , 2017, Cancer research.

[2]  David M. Thomas,et al.  IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting , 2017, Nature Communications.

[3]  T. Ushijima,et al.  Systemic Administration of Small Interfering RNA Targeting Human Nestin Inhibits Pancreatic Cancer Cell Proliferation and Metastasis , 2016, Pancreas.

[4]  Umar Mahmood,et al.  Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. , 2015, Cancer cell.

[5]  N. Bardeesy,et al.  Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up. , 2015, Cancer discovery.

[6]  Masashi Fukayama,et al.  EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway , 2015, Cell Discovery.

[7]  K. Tsuneyama,et al.  Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation , 2015, Cancer science.

[8]  J. Neradil,et al.  Nestin as a marker of cancer stem cells , 2015, Cancer science.

[9]  K. Miyazono,et al.  Smad4 Decreases the Population of Pancreatic Cancer-Initiating Cells through Transcriptional Repression of ALDH1A1. , 2015, The American journal of pathology.

[10]  Michael A. Choti,et al.  Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets , 2015, Nature Communications.

[11]  Z Li,et al.  Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma , 2014, Cell Death and Disease.

[12]  H. Aburatani,et al.  Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells , 2014, Cancer science.

[13]  H. Zhang,et al.  Nestin positively regulates the Wnt/β-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells , 2014, Breast Cancer Research.

[14]  Stephen A. Sastra,et al.  Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. , 2014, Cancer cell.

[15]  A. Krešo,et al.  Evolution of the cancer stem cell model. , 2014, Cell stem cell.

[16]  T. Ohtsuka,et al.  MAL2 expression predicts distant metastasis and short survival in pancreatic cancer. , 2013, Surgery.

[17]  Andrew M. K. Brown,et al.  Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer , 2013, Science.

[18]  H. Johnsen,et al.  Cancer stem cell definitions and terminology: the devil is in the details , 2012, Nature Reviews Cancer.

[19]  Carlos Cuevas,et al.  Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.

[20]  Adrian O'Dowd,et al.  Only women with symptoms need to have their breast implants removed, says government , 2012, BMJ : British Medical Journal.

[21]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[22]  M. Nowak,et al.  Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer , 2010, Nature.

[23]  P. Lu,et al.  Clinical implications for nestin protein expression in breast cancer , 2010, Cancer science.

[24]  D. Ribatti,et al.  The stem cell marker nestin predicts poor prognosis in human melanoma. , 2009, Oncology reports.

[25]  Takeshi Imamura,et al.  Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β* , 2009, Journal of Biological Chemistry.

[26]  K. Miyazono,et al.  Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway , 2008, Oncogene.

[27]  Douglas B. Evans,et al.  Cancer-associated stromal fibroblasts promote pancreatic tumor progression. , 2008, Cancer research.

[28]  C. Heeschen,et al.  Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. , 2007, Cell stem cell.

[29]  T. Strojnik,et al.  Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survival. , 2007, Surgical neurology.

[30]  J. Eriksson,et al.  A nestin scaffold links Cdk5/p35 signaling to oxidant‐induced cell death , 2006, The EMBO journal.

[31]  J. Joyce,et al.  Therapeutic Targeting of the Tumor Microenvironment. , 2021, Cancer discovery.

[32]  A. Buck,et al.  Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. , 2005, Gastroenterology.

[33]  Z. Kolár̂,et al.  Nestin as a diagnostic and prognostic marker: immunohistochemical analysis of its expression in different tumours , 2005, Journal of Clinical Pathology.

[34]  I. Fidler,et al.  The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited , 2003, Nature Reviews Cancer.

[35]  K. Ohuchida,et al.  Co-cultivation of pancreatic cancer cells with orthotopic tumor-derived fibroblasts: fibroblasts stimulate tumor cell invasion via HGF secretion whereas cancer cells exert a minor regulative effect on fibroblasts HGF production. , 2003, Cancer letters.

[36]  R. DePinho,et al.  Pancreatic cancer biology and genetics , 2002, Nature Reviews Cancer.

[37]  H. Aburatani,et al.  Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. , 2001, Cancer research.

[38]  H. Kocher,et al.  Pancreatic Cancer , 2019, Methods in Molecular Biology.

[39]  J. Salk.  Clonal evolution in cancer , 2010 .

[40]  Wolfgang Schima,et al.  Pancreatic adenocarcinoma , 2006, European Radiology.