Palladium-catalyzed carbonylative cyclization of β-bromo-α,β-unsaturated carboxylic acids with 2,2-dimethylhydrazine leading to 1-(dimethylamino)-1H-pyrrole-2,5-diones

β-Bromo-α,β-unsaturated carboxylic acids are carbonylatively cyclized with 2,2-dimethylhydrazine under carbon monoxide pressure in THF in the presence of a catalytic amount of a palladium catalyst along with a base to give 1-(dimethylamino)-1H-pyrrole-2,5-diones. Copyright © 2014 John Wiley & Sons, Ltd.

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