The Temperature Effect

In Chapter 5, target molecular weights for various enzymes were calculated from the 37%-doses measured at room temperature, and the results compared with the true molecular weights of the irradiated biomolecules. As there is no rational reason to attach any special significance to the results obtained at room temperature, the dependence of inactivation rate on the temperature during exposure will now be examined. In some ways, this chapter could be considered as an extension of the target theory; furthermore, some additional features of the indirect effect (see Chapter 6) will become apparent, the significance of which is enhanced by the observation of a remarkable uniformity in the temperature-dependence of many biological systems under irradiation.

[1]  P. Spiegler,et al.  Thermal‐Spike Model of Low LET Radiolysis: Temperature Dependence of Reactions Induced by Radiolysis in Liquid Toluene , 1964 .

[2]  W. Günther,et al.  Der Einfluß der Temperatur auf die Strahlenempfindlichkeit von Ribonuclease , 1967 .

[3]  E. Pollard,et al.  Combined thermal and primary ionization effects on a bacterial virus. , 1952, Archives of biochemistry and biophysics.

[4]  E. Pollard,et al.  The Physical Inactivation of Invertase. , 1952, Proceedings of the National Academy of Sciences of the United States of America.

[5]  R. Vollmer,et al.  Temperature Dependence of Ionizing Radiation Effect on Dry Hyaluronidase , 1967 .

[6]  P. Spiegler,et al.  Thermal Spikes in Protein , 1962 .

[7]  E. L. Powers,et al.  The Influence of Temperature Upon the Inactivation of a Bacterial Virus By X-Rays. , 1953, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Friedrich Dessauer,et al.  Über einige Wirkungen von Strahlen. IV , 1923 .

[9]  T. Henriksen Effect of the irradiation temperature on the production of free radicals in solid biological compounds exposed to various ionizing radiations. , 1966, Radiation research.

[10]  D. Fluke Temperature dependence of ionizing radiation effect on dry lysozyme and ribonuclease. , 1966, Radiation research.

[11]  G. Hotz,et al.  The action of heat and ionizing radiation on the infectivity of isolated phi-X-174 DNA. , 1968, Proceedings of the National Academy of Sciences of the United States of America.