Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells.

[1]  F. Estévez,et al.  Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells , 2014, Molecular carcinogenesis.

[2]  F. Greco,et al.  Flavonoids as prospective compounds for anti-cancer therapy. , 2013, The international journal of biochemistry & cell biology.

[3]  Michael Wiese,et al.  Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2. , 2013, European journal of medicinal chemistry.

[4]  M. F. Proença,et al.  Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin. , 2013, European journal of medicinal chemistry.

[5]  L. Monasta,et al.  TRAIL-based therapeutic approaches for the treatment of pediatric malignancies. , 2013, Current medicinal chemistry.

[6]  L. Ouyang,et al.  Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis , 2012, Cell proliferation.

[7]  S. Cutler,et al.  Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling. , 2012, European journal of medicinal chemistry.

[8]  Jae In Lee,et al.  An Effective Synthesis of 3-Methoxyflavones via 1-(2-Hydroxyphenyl)-2-methoxy-3-phenyl-1,3-propanediones , 2012 .

[9]  F. Estévez,et al.  Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway. , 2011, Cancer letters.

[10]  R. Seger,et al.  The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. , 2011, Biochimica et biophysica acta.

[11]  J. Buolamwini,et al.  Interaction of benzopyranone derivatives and related compounds with human concentrative nucleoside transporters 1, 2 and 3 heterologously expressed in porcine PK15 nucleoside transporter deficient cells. Structure-activity relationships and determinants of transporter affinity and selectivity. , 2010, Biochemical pharmacology.

[12]  Gen Sheng Wu.  TRAIL as a target in anti-cancer therapy. , 2009, Cancer letters.

[13]  G. Salvesen,et al.  Human Caspases: Activation, Specificity, and Regulation* , 2009, The Journal of Biological Chemistry.

[14]  Junying Yuan,et al.  Caspases in apoptosis and beyond , 2008, Oncogene.

[15]  Min Chen,et al.  Synthesis of a library of glycosylated flavonols , 2008, Tetrahedron Letters.

[16]  T. Walle.  Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? , 2007, Seminars in cancer biology.

[17]  F. Estévez,et al.  Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK. , 2007, Carcinogenesis.

[18]  Rony Seger,et al.  The MEK/ERK cascade: from signaling specificity to diverse functions. , 2007, Biochimica et biophysica acta.

[19]  Wei Chen,et al.  Differential regulation and properties of MAPKs , 2007, Oncogene.

[20]  L. Goya,et al.  Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). , 2006, The Journal of nutrition.

[21]  F. Estévez,et al.  Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents. , 2006, European journal of pharmacology.

[22]  Joong-Hoon Ahn,et al.  Complete assignment of 1H and 13C NMR data of some flavonol derivatives , 2005, Magnetic resonance in chemistry : MRC.

[23]  T. Ho,et al.  Morin inhibits 12-O-tetradecanoylphorbol-13-acetate-induced hepatocellular transformation via activator protein 1 signaling pathway and cell cycle progression. , 2005, Biochemical pharmacology.

[24]  Ching-Shu Lai,et al.  Induction of apoptosis by luteolin through cleavage of Bcl-2 family in human leukemia HL-60 cells. , 2005, European journal of pharmacology.

[25]  S. Shankar,et al.  Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: mechanisms and clinical implications. , 2004, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[26]  J. Dickenson,et al.  Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death. , 2004, European journal of pharmacology.

[27]  H. Huynh,et al.  The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. , 2003, Carcinogenesis.

[28]  G. Shore,et al.  Regulation of apoptosis by endoplasmic reticulum pathways , 2003, Oncogene.

[29]  S. Shen,et al.  Differential apoptosis‐inducing effect of quercetin and its glycosides in human promyeloleukemic HL‐60 cells by alternative activation of the caspase 3 cascade , 2003, Journal of cellular biochemistry.

[30]  Young-ho Kim,et al.  Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. , 2003, Carcinogenesis.

[31]  E. Newcomb,et al.  Cleavage of Bax enhances its cell death function. , 2000, Experimental cell research.

[32]  M. Boyd,et al.  Structure-activity requirements for flavone cytotoxicity and binding to tubulin. , 1998, Journal of medicinal chemistry.

[33]  L. Pieters,et al.  4′‐Hydroxy‐3‐methoxyflavones with Potent Antipicornavirus Activity. , 1991 .

[34]  L. Pieters,et al.  4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. , 1991, Journal of medicinal chemistry.

[35]  A. Strasser,et al.  The BCL-2 protein family: opposing activities that mediate cell death , 2008, Nature Reviews Molecular Cell Biology.

[36]  R. Stierum,et al.  Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer–related mechanisms in colon cancer cells in vitro , 2005, European journal of nutrition.

[37]  H. Kamata,et al.  Redox regulation of cellular signalling. , 1999, Cellular signalling.

[38]  Y. Vibhute,et al.  STUDIES ON SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW CHALCONES, FLAVONES AND FLAVONOLS , 1992 .