Ethical issues associated with the use of animal experimentation in behavioral neuroscience research.

This chapter briefly explores whether there are distinct characteristics in the field of Behavioral Neuroscience that demand specific ethical reflection. We argue that although the ethical issues in animal-based Behavioral Neuroscience are not necessarily distinct from those in other research disciplines using animal experimentation, this field of endeavor makes a number of specific, ethically relevant, questions more explicit and, as a result, may expose to discussion a series of ethical issues that have relevance beyond this field of science. We suggest that innovative research, by its very definition, demands out-of-the-box thinking. At the same time, standardization of animal models and test procedures for the sake of comparability across experiments inhibits the potential and willingness to leave well-established tracks of thinking, and leaves us wondering how open minded research is and whether it is the researcher's established perspective that drives the research rather than the research that drives the researcher's perspective. The chapter finishes by introducing subsequent chapters of this book volume on Ethical Issues in Behavioral Neuroscience.

[1]  Mary Anne Warren,et al.  Moral Status: Obligations to Persons and Other Living Things , 1998 .

[2]  Alan D. Lopez,et al.  Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study , 1997, The Lancet.

[3]  M. Rowlands Animals Like Us , 2002 .

[4]  D. Degrazia,et al.  Taking Animals Seriously-Mental life and moral status , 1996 .

[5]  P. Carruthers The Animals Issue , 1992 .

[6]  B. Bovenkerk,et al.  The Biotechnology Debate , 2012 .

[7]  A. Roskies Neuroethics for the New Millenium , 2002, Neuron.

[8]  F. J. van der Staay,et al.  Evaluation of animal models of neurobehavioral disorders , 2009, Behavioral and Brain Functions.

[9]  J. Baird Callicott,et al.  Animal Liberation: A Triangular Affair , 1980 .

[10]  L. V. Zutphen,et al.  Principles of Laboratory Animal Science , 1993 .

[11]  Augusto Vitale,et al.  The application of Russell and Burch 3R principle in rodent models of neurodegenerative disease: The case of Parkinson’s disease , 2009, Neuroscience & Biobehavioral Reviews.

[12]  David DeGrazia,et al.  Taking animals seriously , 1996 .

[13]  Crazy Like a Fox , 2014, Cambridge Quarterly of Healthcare Ethics.

[14]  Animal Minds and Neuroimaging , 2014, Cambridge Quarterly of Healthcare Ethics.

[15]  Vera Rogiers,et al.  Opportunities for an alternative integrating testing strategy for carcinogen hazard assessment? , 2012, Critical reviews in toxicology.

[16]  F. Brom Science and society: different bioethical approaches towards animal experimentation. , 2002, ALTEX.

[17]  Vera Baumans,et al.  Principles of laboratory animal science : a contribution to the humane use and care of animals and to the quality of experimental results , 1993 .

[18]  N. Franco Animal Experiments in Biomedical Research: A Historical Perspective , 2013, Animals : an open access journal from MDPI.

[19]  Christine M. Korsgaard Fellow Creatures: Kantian Ethics and Our Duties to Animals , 2004 .

[20]  Benjamin Sambale Definitions and Facts , 2014 .

[21]  B. Rollin Animal Rights & Human Morality , 1981 .

[22]  F. Bloom,et al.  Psychopharmacology: The Fourth Generation of Progress , 1995 .

[23]  T. Regan The case for animal rights : updated with a new preface , 2004 .

[24]  B. Sahakian,et al.  The Oxford Handbook of Neuroethics , 2011 .

[25]  A. Linzey The Global Guide to Animal Protection , 2013 .

[26]  Jane Huggins Albumin effects on drug absorption and metabolism in reconstructed epidermis and excised pig skin. , 2003 .

[27]  M. Nussbaum Frontiers of Justice: Disability, Nationality, Species Membership , 2006 .

[28]  H. Stefánsson The biology of behaviour: scientific and ethical implications , 2007, EMBO reports.

[29]  P. Singer,et al.  Animal Liberation: towards an end to man's inhumanity to animals , 1983 .

[30]  G. Koob,et al.  Animal models of psychiatric disorders. , 2012, Handbook of clinical neurology.

[31]  J. Ayuso-Mateos,et al.  Definitions and factors associated with subthreshold depressive conditions: a systematic review , 2012, BMC Psychiatry.

[32]  C. Montani,et al.  Alternatives to animal experimentation for hormonal compounds research , 2009, Genes & Nutrition.

[33]  C. Hendriksen,et al.  Replacement, reduction and refinement alternatives to animal use in vaccine potency measurement , 2009, Expert review of vaccines.

[34]  Martha Craven Nussbaum,et al.  Frontiers of Justice: Disability, Nationality, Species Membership , 2006 .

[35]  W. Russell,et al.  Ethical and Scientific Considerations Regarding Animal Testing and Research , 2011, PloS one.

[36]  B. Ruggeri,et al.  Animal models of human disease: challenges in enabling translation. , 2014, Biochemical pharmacology.

[37]  B. Rollin Animal Pain: What It is and Why It Matters , 2011 .

[38]  Paul W. Taylor,et al.  Respect for Nature , 2011, The Virtues of Sustainability.