Localized 1H NMR spectroscopy in Canavan's Disease: A report of two cases

Two children with Canavan's Disease, an autosomal recessive leukodystrophy, were studied by localized 1H spectroscopy. The N‐acetylaspartate (NAA) signal intensity was high relative to other metabolite signals, and the signal intensity from choline‐containing compounds was low. These findings are discussed in relation to a possible role for NAA in normal myelination. © 1991 Academic Press, Inc.

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