Connexins as targets for cancer chemoprevention and chemotherapy.

[1]  J. Bertram,et al.  Inhibition of chemically-induced neoplastic transformation by a novel tetrasodium diphosphate astaxanthin derivative. , 2005, Carcinogenesis.

[2]  J. Bertram,et al.  Upregulation of Connexin 43 by Retinoids but Not by Non-Provitamin A Carotenoids Requires RARs , 2005, Nutrition and cancer.

[3]  D. Laird,et al.  Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype. , 2005, Cancer research.

[4]  M. Weller,et al.  Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas. , 2005, Biochemical and biophysical research communications.

[5]  E. Luebeck,et al.  Modulation of liver tumorigenesis in Connexin32-deficient mouse. , 2005, Mutation research.

[6]  T. Ekström,et al.  HDACi phenylbutyrate increases bystander killing of HSV-tk transfected glioma cells. , 2004, Biochemical and biophysical research communications.

[7]  P. Lampe,et al.  The Gap Junction Protein Connexin32 Is a Mouse Lung Tumor Suppressor , 2004, Cancer Research.

[8]  C. Lo,et al.  Connexins and cell signaling in development and disease. , 2004, Annual review of cell and developmental biology.

[9]  K. Willecke,et al.  Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43. , 2004, Molecular biology of the cell.

[10]  H. Yamasaki,et al.  Increased susceptibility to urethane-induced lung tumors in mice with decreased expression of connexin43. , 2004, Carcinogenesis.

[11]  J. Bertram,et al.  Bioactive carotenoids: potent antioxidants and regulators of gene expression , 2004, Redox report : communications in free radical research.

[12]  Akira Yamanoi,et al.  Expression of gap junction protein connexin32 in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma , 2004, Journal of Gastroenterology.

[13]  J. Bertram,et al.  Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives. , 2004, Cancer letters.

[14]  H. Knutsen,et al.  Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells. , 2004, European journal of cancer.

[15]  T. Ekström,et al.  Histone deacetylase inhibitor 4-phenylbutyrate modulates glial fibrillary acidic protein and connexin 43 expression, and enhances gap-junction communication, in human glioblastoma cells. , 2004, European journal of cancer.

[16]  P. Lampe,et al.  Mice deficient for the gap junction protein Connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/Erk1, p42/Erk2) activation. , 2004, Carcinogenesis.

[17]  K. Willecke,et al.  Exacerbation of benzene pneumotoxicity in connexin 32 knockout mice: enhanced proliferation of CYP2E1-immunoreactive alveolar epithelial cells. , 2004, Toxicology.

[18]  C. Rancourt,et al.  Delivery of herpes simplex thymidine kinase bystander effect by engineered human mesothelial cells for the treatment of ovarian cancer. , 2003, Cytotherapy.

[19]  Wei Zhang,et al.  Increased invasive capacity of connexin43-overexpressing malignant glioma cells. , 2003, Journal of neurosurgery.

[20]  F. Zsila,et al.  Interaction of the disodium disuccinate derivative of meso-astaxanthin with human serum albumin: from chiral complexation to self-assembly. , 2003, Bioorganic & medicinal chemistry letters.

[21]  I. Morita,et al.  The Gap Junction-independent Tumor-suppressing Effect of Connexin 43* , 2003, Journal of Biological Chemistry.

[22]  Ya‐Wen Cheng,et al.  The correlation between aberrant connexin 43 mRNA expression induced by promoter methylation and nodal micrometastasis in non-small cell lung cancer. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[23]  K. Christov,et al.  Effects of Tomato Sauce Consumption on Apoptotic Cell Death in Prostate Benign Hyperplasia and Carcinoma , 2003, Nutrition and cancer.

[24]  J. Zweier,et al.  Direct superoxide anion scavenging by a disodium disuccinate astaxanthin derivative: Relative efficacy of individual stereoisomers versus the statistical mixture of stereoisomers by electron paramagnetic resonance imaging. , 2003, Biochemical and biophysical research communications.

[25]  M. Herlyn,et al.  The Role of Altered Cell–Cell Communication in Melanoma Progression , 2003, Journal of Molecular Histology.

[26]  J. Trosko,et al.  Gap junctions as targets for cancer chemoprevention and chemotherapy. , 2002, Current drug targets.

[27]  M. Mesnil.  Connexins and cancer , 2002, Biology of the cell.

[28]  E. Giovannucci.  A Review of Epidemiologic Studies of Tomatoes, Lycopene, and Prostate Cancer , 2002, Experimental biology and medicine.

[29]  S. Mayne,et al.  Dietary carotenoids, serum beta-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study. , 2002, American journal of epidemiology.

[30]  J. Bertram,et al.  Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of HT‐1080 human fibrosarcoma cells in vitro and in vivo , 2002, Molecular carcinogenesis.

[31]  S. V. Vasil’ev,et al.  Connexin 43, but not connexin 32, is mutated at advanced stages of human sporadic colon cancer , 2002, Oncogene.

[32]  J. Degen,et al.  Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome , 2002, Biological chemistry.

[33]  K. Willecke,et al.  Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32-deficient mice. , 2002, Carcinogenesis.

[34]  M. Banerjee,et al.  Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[35]  I. Morita,et al.  Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27 , 2001, Oncogene.

[36]  C J Kemp,et al.  p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. , 2001, Experimental cell research.

[37]  L. Dwyer-Nield,et al.  Growth inhibition in G1 and altered expression of cyclin D1 and p27kip‐1 after forced connexin expression in lung and liver carcinoma cells , 2000, Journal of cellular biochemistry.

[38]  S. Ylä-Herttuala,et al.  Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses. , 2000, Human gene therapy.

[39]  K. Willecke,et al.  Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice. , 2000, Cancer research.

[40]  K. Willecke,et al.  Unique and shared functions of different connexins in mice , 2000, Current Biology.

[41]  W. Sakr,et al.  Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression. , 2000, Carcinogenesis.

[42]  N. Tsubota,et al.  A role for heterologous gap junctions between melanoma and endothelial cells in metastasis. , 2000, The Journal of clinical investigation.

[43]  M. Herlyn,et al.  Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression. , 2000, Journal of cell science.

[44]  K. Willecke,et al.  The extent of synchronous initiation and termination of DNA synthesis in regenerating mouse liver is dependent on connexin32 expressing gap junctions. , 2000, Journal of hepatology.

[45]  J. Bertram,et al.  Correlation between growth control, neoplastic potential and endogenous connexin43 expression in HeLa cell lines: implications for tumor progression. , 2000, Carcinogenesis.

[46]  H. Yamasaki,et al.  Induction of skin papillomas, carcinomas, and sarcomas in mice in which the connexin 43 gene is heterologously deleted. , 2000, The Journal of investigative dermatology.

[47]  K. Willecke,et al.  Strongly decreased gap junctional permeability to inositol 1,4,5‐trisphosphate in connexin32 deficient hepatocytes , 2000, FEBS letters.

[48]  G. Fishman,et al.  Wnt-1 regulation of connexin43 in cardiac myocytes. , 2000, The Journal of clinical investigation.

[49]  D. Alberts,et al.  Beta-carotene produces sustained remissions in patients with oral leukoplakia: results of a multicenter prospective trial. , 1999, Archives of otolaryngology--head & neck surgery.

[50]  R. Walsh,et al.  Anti- and Prooxidant Properties of Carotenoids. , 1999 .

[51]  R. Walsh,et al.  Anti‐ and Prooxidant Properties of Carotenoids , 1999 .

[52]  J. Cheville,et al.  p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. , 1999, The American journal of pathology.

[53]  M. Russell,et al.  Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. , 1999, Journal of the National Cancer Institute.

[54]  C. Lo,et al.  Heart malformations in transgenic mice exhibiting dominant negative inhibition of gap junctional communication in neural crest cells. , 1998, Developmental biology.

[55]  S. Bale,et al.  Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis , 1998, Nature Genetics.

[56]  K. Fischbeck,et al.  Connexin32‐null mice develop demyelinating peripheral neuropathy , 1998, Glia.

[57]  D. Hülser,et al.  Connexin transfection induces invasive properties in HeLa cells. , 1998, Experimental cell research.

[58]  M. Rook,et al.  Identification of connexin43 as a functional target for Wnt signalling. , 1998, Journal of cell science.

[59]  J. Saurat,et al.  In Vivo Modulation of Connexins 43 and 26 of Human Epidermis by Topical Retinoic Acid Treatment , 1997, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[60]  K. Willecke,et al.  High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32 , 1997, Current Biology.

[61]  W. Zhu,et al.  Increased genetic stability of HeLa cells after connexin 43 gene transfection. , 1997, Cancer research.

[62]  J E Saffitz,et al.  Slow ventricular conduction in mice heterozygous for a connexin43 null mutation. , 1997, The Journal of clinical investigation.

[63]  C. Lo,et al.  Heart and neural tube defects in transgenic mice overexpressing the Cx43 gap junction gene. , 1997, Development.

[64]  N. Gilula,et al.  Perturbation in connexin 43 and connexin 26 gap‐junction expression in mouse skin hyperplasia and neoplasia , 1996, Molecular carcinogenesis.

[65]  K. Willecke,et al.  Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[66]  G. Omenn,et al.  Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. , 1996, The New England journal of medicine.

[67]  J. Manson,et al.  Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. , 1996, The New England journal of medicine.

[68]  J. Palmgren,et al.  Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study. , 1995, The American journal of clinical nutrition.

[69]  T. Slaga,et al.  The expression of gap junctional proteins during different stages of mouse skin carcinogenesis. , 1995, Carcinogenesis.

[70]  M. Mori,et al.  Aberrant expression of gap junction proteins (connexins) is associated with tumor progression during multistage mouse skin carcinogenesis in vivo. , 1995, Carcinogenesis.

[71]  A. Boynton,et al.  Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[72]  A. Lau,et al.  pp60src -mediated Phosphorylation of Connexin 43, a Gap Junction Protein (*) , 1995, The Journal of Biological Chemistry.

[73]  J. Trosko,et al.  Changes in gap‐junction permeability, phosphorylation, and number mediated by phorbol ester and non‐phorbol‐ester tumor promoters in rat liver epithelial cells , 1994, Molecular carcinogenesis.

[74]  D. Alberts,et al.  Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: a randomized trial. , 1994, Journal of the National Cancer Institute.

[75]  R. Warnick,et al.  In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy. , 1993, Human gene therapy.

[76]  J. Bertram,et al.  Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties. , 1992, Cancer research.

[77]  J. Bertram,et al.  Gap-junctional protein connexin 43 is expressed in dermis and epidermis of human skin: differential modulation by retinoids. , 1992, The Journal of investigative dermatology.

[78]  J. Bertram,et al.  Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. , 1991, Carcinogenesis.

[79]  C. Marshall.  Tumor suppressor genes , 1991, Cell.

[80]  L J Peters,et al.  Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. , 1990, The New England journal of medicine.

[81]  W. Loewenstein,et al.  Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation. , 1989, Carcinogenesis.

[82]  J. Bertram,et al.  β-Carotene and canthaxanthin inhibit chemically- and physically- induced neoplastic transformation in 10T1/2 cells , 1988 .

[83]  L. Kolonel,et al.  Rationale and strategies for chemoprevention of cancer in humans. , 1987, Cancer research.

[84]  W. Loewenstein,et al.  Growth inhibition of transformed cells correlates with their junctional communication with normal cells , 1986, Cell.

[85]  K. Ingold,et al.  beta-Carotene: an unusual type of lipid antioxidant. , 1984, Science.

[86]  J. Bertram,et al.  Quantitative neoplastic transformation of C3H/10T1/2 fibroblasts: dependence upon the size of the initiated cell colony at confluence. , 1983, Cancer research.

[87]  J. Bertram,et al.  Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine. , 1980, Cancer research.

[88]  J. Trosko,et al.  Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter. , 1979, Science.

[89]  J. Bertram.  Modulation of cellular interactions between C3H/10T1/2 cells and their transformed counterparts by phosphodiesterase inhibitors. , 1979, Cancer research.

[90]  J. Bertram,et al.  Reversible inhibition by retinoids of 3-methylcholanthrene-induced neoplastic transformation in C3H/10T1/2 clone 8 cells. , 1979, Cancer research.

[91]  W. Loewenstein,et al.  Junctional intercellular communication and the control of growth. , 1979, Biochimica et biophysica acta.

[92]  C. Heidelberger,et al.  Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division. , 1973, Cancer research.

[93]  W. Loewenstein,et al.  Intercellular Communication and the Control of Tissue Growth: Lack of Communication between Cancer Cells , 1966, Nature.

[94]  W. Loewenstein,et al.  Intercellular communication and the control of growth: XII. Alteration of junctional permeability by simian virus 40. roles of the large and smallT antigens , 2005, The Journal of Membrane Biology.

[95]  W. Loewenstein,et al.  Intercellular communication and the control of growth: XI. Alteration of junctional permeability by thesrc gene in a revertant cell with normal cytoskeleton , 2005, The Journal of Membrane Biology.

[96]  J. Bertram,et al.  Cancer Chemoprevention by Connexins , 2004, Cancer and Metastasis Reviews.

[97]  M. Herlyn,et al.  Hsu M, Andl T, Li G, Meinkoth JL, Herlyn MCadherin repertoire determines partner-specific gap junctional communication during melanoma progression. J Cell Sci 113: 1535-1542 , 2000 .

[98]  D. Paul,et al.  Gap junctional intercellular communication in the mouse ovarian follicle. , 1999, Novartis Foundation symposium.

[99]  K. Matsumoto,et al.  Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression. , 1995, Carcinogenesis.

[100]  J. Bertram,et al.  Beta-carotene and canthaxanthin inhibit chemically- and physically-induced neoplastic transformation in 10T1/2 cells. , 1988, Carcinogenesis.

[101]  J. Bertram,et al.  Inhibition of Neoplastic Cell Growth by Quiescent Cells Is Mediated by Serum Concentration and cAMP Phosphodiesterase Inhibitors , 1982, Journal of cellular biochemistry.