Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

David M. Evans | D. Kiel | M. Nalls | A. Uitterlinden | T. Spector | K. Stefánsson | S. Grant | B. Horta | F. Rivadeneira | C. Duijn | T. Ahluwalia | K. Bønnelykke | H. Bisgaard | Yongmei Liu | B. Psaty | J. Robbins | T. Harris | T. Lakka | H. Zheng | N. Wareham | C. V. van Duijn | G. Sigurdsson | J. Richards | U. Styrkarsdottir | M. Heijer | R. Jackson | M. Ikram | D. Evans | J. Kemp | N. Amin | Daniel S. Evans | James F. Wilson | B. Zemel | F. Hartwig | J. Luan | R. Scott | R. de Mutsert | E. Evangelou | M. Ghanbari | C. Langenberg | D. Mook-Kanamori | C. Ohlsson | Ching‐Ti Liu | M. Atalay | J. Zhao | M. den Heijer | V. Jaddoe | L. Jessen | S. Ralston | M. Zillikens | M. Lorentzon | A. Chesi | C. Medina-Gomez | N. van der Velde | L. Broer | R. Li-Gao | C. Pennell | Carol A. Wang | E. Ntzani | S. Handelman | F. Williams | C. Ackert-Bicknell | A. V. van Wijnen | J. van de Peppel | P. Croucher | E. Orwoll | K. Zhu | R. Joro | J. Walsh | J. Tobias | B. Mullin | Scott G Wilson | J. Felix | D. Karasik | Yanhua Zhou | B. V. D. van der Eerden | J. Bassett | J. Logan | G. Williams | B. Chawes | K. Schraut | V. Forgetta | K. Trajanoska | David M. Evans | R. Mutsert | A. Ham | K. Akesson | F. McGuigan | I. Nedeljkovic | Maria Nethander | N. Velde | A. V. Wijnen | J. B. Richards | Christian J Carlsson | C. Boer | J. Peppel | D. Evans | Gudmar Porleifsson | D. Heppe | M. Nethander | Katharina E. Schraut | B. C. van der Eerden | K. Åkesson | U. Styrkársdóttir | S. Wilson | D. S. Evans | B. V. D. Eerden | R. Jackson | C. J. Carlsson | Houfeng Zheng | A. Uitterlinden | Bram C. J. Eerden | R. Scott | B. Psaty | R. Scott | J. B. Richards | S. Wilson | R. Scott | J. Walsh | G. Williams | K. Zhu | Vincenzo Forgetta | Scott G Wilson | R. Jackson

[1]  L. Straker,et al.  Cohort Profile Cohort Profile : The Western Australian Pregnancy Cohort ( Raine ) Study – Generation 2 , 2017 .

[2]  G. Mortier,et al.  The Lrp4R1170Q Homozygous Knock‐In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans , 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  H. Westerhoff,et al.  Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics , 2017, Stem cell reports.

[4]  M. Zillikens,et al.  Osteoclastogenic capacity of peripheral blood mononuclear cells is not different between women with and without osteoporosis. , 2017, Bone.

[5]  T. Baum,et al.  Serum miRNA Signatures Are Indicative of Skeletal Fractures in Postmenopausal Women With and Without Type 2 Diabetes and Influence Osteogenic and Adipogenic Differentiation of Adipose Tissue–Derived Mesenchymal Stem Cells In Vitro , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[6]  D. Kiel,et al.  Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2 , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[7]  O. Franco,et al.  The Generation R Study: design and cohort update 2017 , 2016, European journal of epidemiology.

[8]  Ewan Birney,et al.  GARFIELD - GWAS Analysis of Regulatory or Functional Information Enrichment with LD correction , 2016, bioRxiv.

[9]  P. Croucher,et al.  Rapid phenotyping of knockout mice to identify genetic determinants of bone strength , 2016, The Journal of endocrinology.

[10]  G. Kullak-Ublick,et al.  Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor , 2016, The Journal of Steroid Biochemistry and Molecular Biology.

[11]  Steve D. M. Brown,et al.  High-throughput discovery of novel developmental phenotypes , 2016, Nature.

[12]  Hui Shen,et al.  Association of 3q13.32 variants with hip trochanter and intertrochanter bone mineral density identified by a genome-wide association study , 2016, Osteoporosis International.

[13]  T. Lakka,et al.  The effects of a 2-year individualized and family-based lifestyle intervention on physical activity, sedentary behavior and diet in children. , 2016, Preventive medicine.

[14]  Tom R. Gaunt,et al.  LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis , 2016, bioRxiv.

[15]  T. Ulmer,et al.  MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis , 2016, Genes & development.

[16]  A. Sigurdsson,et al.  Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures , 2016, Nature Communications.

[17]  U. Thorsteinsdóttir,et al.  Two Rare Mutations in the COL1A2 Gene Associate With Low Bone Mineral Density and Fractures in Iceland , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[18]  T. Craig,et al.  Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3. , 2015, Biochemical and biophysical research communications.

[19]  Beth Wilmot,et al.  Edinburgh Explorer Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture , 2022 .

[20]  S. Khosla,et al.  Skeletal changes through the lifespan—from growth to senescence , 2015, Nature Reviews Endocrinology.

[21]  P. Visscher,et al.  Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index , 2015, Nature Genetics.

[22]  W. Hul,et al.  A look behind the scenes: the risk and pathogenesis of primary osteoporosis , 2015, Nature Reviews Rheumatology.

[23]  F. Tirone,et al.  Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton , 2015, PloS one.

[24]  Henrik Westerberg,et al.  Analysis of mammalian gene function through broad based phenotypic screens across a consortium of mouse clinics , 2015, Nature Genetics.

[25]  Albert Hofman,et al.  Genetic Variations in MicroRNA-Binding Sites Affect MicroRNA-Mediated Regulation of Several Genes Associated With Cardio-metabolic Phenotypes , 2015, Circulation. Cardiovascular genetics.

[26]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[27]  A. Hofman,et al.  Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study , 2015, European Journal of Epidemiology.

[28]  Cesar G Victora,et al.  Cohort Profile Update: The 1982 Pelotas (Brazil) Birth Cohort Study , 2015, International journal of epidemiology.

[29]  J. Hirschhorn,et al.  Biological interpretation of genome-wide association studies using predicted gene functions , 2015, Nature Communications.

[30]  Florian Kronenberg,et al.  EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data , 2015, Bioinform..

[31]  J. Ousingsawat,et al.  Anoctamin-6 Controls Bone Mineralization by Activating the Calcium Transporter NCX1* , 2015, The Journal of Biological Chemistry.

[32]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[33]  Benjamin M. Neale,et al.  Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium , 2015 .

[34]  P. Visscher,et al.  Title: Across-cohort Qc Analyses of Genome-wide Association Study Summary Statistics from Complex Traits Wray 1 , the Genetic Investigation of Anthropometric Traits (giant) Consortium , 2015 .

[35]  E. Jimi,et al.  Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling , 2014, Scientific Reports.

[36]  Sung‐Min Ahn,et al.  Dual‐Specificity Phosphatase 5 Attenuates Autoimmune Arthritis in Mice via Reciprocal Regulation of the Th17/Treg Cell Balance and Inhibition of Osteoclastogenesis , 2014, Arthritis & rheumatology.

[37]  Andrew D. Johnson,et al.  Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. , 2014, American journal of human genetics.

[38]  D. Kiel,et al.  Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. , 2014, Human molecular genetics.

[39]  Matthew A. Hibbs,et al.  Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment , 2014, PLoS genetics.

[40]  Zoltán Kutalik,et al.  Quality control and conduct of genome-wide association meta-analyses , 2014, Nature Protocols.

[41]  A. Uitterlinden,et al.  Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. , 2014, Human molecular genetics.

[42]  Hicham Drissi,et al.  Runx1-mediated regulation of osteoclast differentiation and function. , 2014, Molecular endocrinology.

[43]  Gautier Koscielny,et al.  The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data , 2013, Nucleic Acids Res..

[44]  Yan Cui,et al.  PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways , 2013, Nucleic Acids Res..

[45]  A. Butterworth,et al.  Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data , 2013, Genetic epidemiology.

[46]  Lorna M. Lopez,et al.  Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations , 2013, PLoS genetics.

[47]  O. Olopade,et al.  Regulation of Tcf7l1 DNA binding and protein stability as principal mechanisms of Wnt/β-catenin signaling. , 2013, Cell reports.

[48]  Daniel F. Gudbjartsson,et al.  Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits , 2013, Nature.

[49]  Daniel L. Koller,et al.  Meta‐analysis of genome‐wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[50]  Joel Eriksson,et al.  Genetic Determinants of Trabecular and Cortical Volumetric Bone Mineral Densities and Bone Microstructure , 2013, PLoS genetics.

[51]  D. Lawlor,et al.  Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children , 2012, International journal of epidemiology.

[52]  P. Gerdhem,et al.  Degenerative changes at the lumbar spine—implications for bone mineral density measurement in elderly women , 2013, Osteoporosis International.

[53]  David M. Evans,et al.  Meta-Analysis of Genome-Wide Scans for Total Body BMD in Children and Adults Reveals Allelic Heterogeneity and Age-Specific Effects at the WNT16 Locus , 2012, PLoS genetics.

[54]  Daniel L. Koller,et al.  Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture , 2012, Nature Genetics.

[55]  P. Visscher,et al.  Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits , 2012, Nature Genetics.

[56]  Hong-Mei Zhang,et al.  Genome‐wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis , 2012, Human mutation.

[57]  O. Franco,et al.  The Rotterdam Study: 2012 objectives and design update , 2011, European Journal of Epidemiology.

[58]  Jun Yu Li,et al.  Genetic variants in the SOX6 gene are associated with bone mineral density in both Caucasian and Chinese populations , 2012, Osteoporosis International.

[59]  T. Hangartner,et al.  Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: results of the bone mineral density in childhood study. , 2011, The Journal of clinical endocrinology and metabolism.

[60]  T. Spector,et al.  Association between DHEAS and Bone Loss in Postmenopausal Women: A 15-Year Longitudinal Population-Based Study , 2011, Calcified Tissue International.

[61]  T. Takenawa,et al.  Involvement of PRIP, Phospholipase C-related, but Catalytically Inactive Protein, in Bone Formation* , 2011, The Journal of Biological Chemistry.

[62]  F. Gianfrancesco,et al.  Genome-wide association identifies three new susceptibility loci for Paget's disease of bone , 2011, Nature Genetics.

[63]  D. Kiel,et al.  Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms , 2011, PLoS genetics.

[64]  Udo Hoffmann,et al.  Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits , 2011, PLoS genetics.

[65]  D. Weinberger,et al.  MicroSNiPer: a web tool for prediction of SNP effects on putative microRNA targets , 2010, Human mutation.

[66]  Wolfgang Viechtbauer,et al.  Conducting Meta-Analyses in R with the metafor Package , 2010 .

[67]  U. Ekelund,et al.  Association between birth weight and visceral fat in adults. , 2010, The American journal of clinical nutrition.

[68]  Jean-Philippe Antignac,et al.  Assessment of circulating sex steroid levels in prepubertal and pubertal boys and girls by a novel ultrasensitive gas chromatography-tandem mass spectrometry method. , 2010, The Journal of clinical endocrinology and metabolism.

[69]  S. Hino,et al.  Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice , 2010, Journal of Bone and Mineral Metabolism.

[70]  A. Dudley,et al.  Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes , 2009, Development.

[71]  R. Fodde,et al.  Adenomatous polyposis coli-mediated control of β-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors , 2009, BMC Developmental Biology.

[72]  B. Zemel,et al.  The bone mineral density in childhood study: bone mineral content and density according to age, sex, and race. , 2007, The Journal of clinical endocrinology and metabolism.

[73]  T. Ma,et al.  Reduced Bone Mineral Density and Bone Metabolism in Aquaporin-1 Knockout Mice , 2007 .

[74]  Soo Young Lee,et al.  MafB negatively regulates RANKL-mediated osteoclast differentiation. , 2007, Blood.

[75]  O. MacDougald,et al.  Regulation of bone mass by Wnt signaling. , 2006, The Journal of clinical investigation.

[76]  C. Victora,et al.  Cohort profile: the 1982 Pelotas (Brazil) birth cohort study. , 2006, International journal of epidemiology.

[77]  S. Cummings,et al.  Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study--a large observational study of the determinants of fracture in older men. , 2005, Contemporary clinical trials.

[78]  P. Cawthon,et al.  Overview of recruitment for the osteoporotic fractures in men study (MrOS). , 2005, Contemporary clinical trials.

[79]  J. Cauley,et al.  Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. , 2005, Archives of internal medicine.

[80]  A. Silman,et al.  Predictive Value of BMD for Hip and Other Fractures , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[81]  D. Mellström,et al.  Age of Attainment of Peak Bone Mass Is Site Specific in Swedish Men—The GOOD Study , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[82]  Tomohiro Otani,et al.  Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. , 2005, The Journal of biological chemistry.

[83]  E. Wagner,et al.  CD44 is a determinant of inflammatory bone loss , 2005, The Journal of experimental medicine.

[84]  H. Bisgaard.  The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study. , 2004, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[85]  A. Seth,et al.  Ets2 transcription factor inhibits mineralization and affects target gene expression during osteoblast maturation. , 2004, In vivo.

[86]  Nathalie de Rekeneire,et al.  Diabetes Is Associated Independently of Body Composition With BMD and Bone Volume in Older White and Black Men and Women: The Health, Aging, and Body Composition Study , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[87]  B. Halloran,et al.  Expression of RANKL and OPG Correlates With Age‐Related Bone Loss in Male C57BL/6 Mice , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[88]  E. Remmers,et al.  Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat. , 2002, Biochemical and biophysical research communications.

[89]  S. Kritchevsky,et al.  Leg Muscle Mass and Composition in Relation to Lower Extremity Performance in Men and Women Aged 70 to 79: The Health, Aging and Body Composition Study , 2002, Journal of the American Geriatrics Society.

[90]  Miikka Vikkula,et al.  LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development , 2001, Cell.

[91]  Xiao-Fan Wang,et al.  The Loss of Smad3 Results in a Lower Rate of Bone Formation and Osteopenia Through Dysregulation of Osteoblast Differentiation and Apoptosis , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[92]  K. Toda,et al.  Sex- and age-related response to aromatase deficiency in bone. , 2001, Biochemical and biophysical research communications.

[93]  G E Dallal,et al.  Application of bioelectrical impedance analysis to elderly populations. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[94]  F. Stanley,et al.  Effects of frequent ultrasound during pregnancy: a randomised controlled trial , 1993, The Lancet.

[95]  R. Kronmal,et al.  The Cardiovascular Health Study: design and rationale. , 1991, Annals of epidemiology.

[96]  H K Genant,et al.  Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group. , 1990, JAMA.

[97]  W. Kannel,et al.  An investigation of coronary heart disease in families. The Framingham offspring study. , 1979, American journal of epidemiology.

[98]  W. Kannel,et al.  The Framingham Offspring Study. Design and preliminary data. , 1975, Preventive medicine.

[99]  W. Kannel,et al.  AN APPROACH TO LONGITUDINAL STUDIES IN A COMMUNITY: THE FRAMINGHAM STUDY , 1963, Annals of the New York Academy of Sciences.

[100]  T. Dawber,et al.  Epidemiological approaches to heart disease: the Framingham Study. , 1951, American journal of public health and the nation's health.