Paracoccidioidomicose: freqüência, morfologia e patogênese de lesões tegumentares

BACKGROUND: Paracoccidioidomycosis is a highly prevalent systemic mycosis in Brazil. The oral and cutaneous lesions are useful for diagnostic proposals and clinical follow-up. OBJECTIVE: To quantify and qualify skin lesions associated to active paracoccidioidomycosis and to correlate them with the clinical form and severity of cases. METHODS: An observational clinical study of cases was performed. Patients were classified according to the clinical form, topographic distribution and morphology of skin lesions. RESULTS: A total of 152 patients classified as chronic form (adult type) (87.5%) or acute-subacute form (juvenile type) (12.5%) were studied. Skin lesion was diagnosed in 61.2% of patients. There was no statistical correlation between presence of skin lesion and clinical form (p=1.000), nor between skin lesion and severity of disease (p=0.5607). There was statistical correlation between mucosal lesion and adult patients (p <0.001). The lesions were on the cephalic segment (47.6%), trunk (14.9%), upper limbs (14.9%), lower limbs (21.7%) and genital region (0.7%). The ulcerated lesions (42.8%) and infiltrative (26.6%) lesions prevailed. CONCLUSION: The frequency of skin lesions and their morphology are useful for diagnosis of paracoccidioidomycosis. Oral lesions in the acute-subacute form (juvenile type) are not common.

[1]  M. Franco,et al.  Molecular detection of Paracoccidioides brasiliensis in soil. , 2005, Medical mycology.

[2]  Christopher Lawrence Pathology , 1911, The Lancet.

[3]  A. T. Londero,et al.  Paracoccidioidomycosis in childhood , 1983, Mycopathologia.

[4]  S. A. Marques Paracoccidioidomicose: atualização epidemiológica, clínica e terapêutica , 2003 .

[5]  S. M. Shelly Cutaneous lesions. , 2003, The Veterinary clinics of North America. Small animal practice.

[6]  R. Negroni,et al.  Mycoses associated with AIDS in the Third World. , 2000, Medical mycology.

[7]  M. R. Montenegro,et al.  Paracoccidioidomycosis: a recently proposed classification of its clinical forms. , 1987, Revista da Sociedade Brasileira de Medicina Tropical.

[8]  J. W. Wilson,et al.  Primary cutaneous coccidioidomycosis; the criteria for diagnosis and a report of a case. , 1953, California medicine.