Plasma Homocysteine and Cognitive Impairment in an Older British African‐Caribbean Population

OBJECTIVES: To investigate the association between homocysteine concentrations and cognitive impairment in an older African‐Caribbean population. To investigate other measures of risk for vascular disease and nutritional status as potential confounding factors.

[1]  L. Gustafson,et al.  Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine , 2001, International journal of geriatric psychiatry.

[2]  R. Stewart,et al.  Apolipoprotein E Genotype, Vascular Risk and Early Cognitive Impairment in an African Caribbean Population , 2001, Dementia and Geriatric Cognitive Disorders.

[3]  C. Brayne,et al.  Cognitive function in UK community‐dwelling African Caribbean elders: normative data for a test battery , 2001, International journal of geriatric psychiatry.

[4]  R. Stewart,et al.  Vascular Risk and Cognitive Impairment in an Older, British, African‐Caribbean Population , 2001 .

[5]  C. Franceschi,et al.  Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment , 2001, Mechanisms of Ageing and Development.

[6]  D. Royall.  Executive Cognitive Impairment: A Novel Perspective on Dementia , 2000, Neuroepidemiology.

[7]  Jun-Hyun Yoo,et al.  Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[8]  C. Chew‐Graham,et al.  Screening for cognitive impairment in older African-Caribbeans , 2000, Psychological Medicine.

[9]  C. Brayne,et al.  Cognitive function in UK community‐dwelling African Caribbean and white elders: a pilot study , 2000, International journal of geriatric psychiatry.

[10]  T. del Ser,et al.  Poststroke dementia : clinical features and risk factors. , 2000, Stroke.

[11]  M. Idelson,et al.  The C677T Mutation in the Methylenetetrahydrofolate Reductase (MTHFR) Gene and Vascular Dementia , 2000, Journal of the American Geriatrics Society.

[12]  Roberta F. White,et al.  The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort. , 2000, Archives of neurology.

[13]  R. Glynn,et al.  Blood levels of homocysteine and increased risks of cardiovascular disease: causal or casual? , 2000, Archives of internal medicine.

[14]  D. Knook,et al.  Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85 , 1999, Journal of neurology, neurosurgery, and psychiatry.

[15]  A. Hofman,et al.  Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study. , 1999, American journal of epidemiology.

[16]  G. Hankey,et al.  Homocysteine and vascular disease , 1999, The Lancet.

[17]  R Clarke,et al.  Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. , 1998, Archives of neurology.

[18]  T. M. Kashner,et al.  The Effect of Vitamin B12 Deficiency on Older Veterans and Its Relationship to Health , 1998, Journal of the American Geriatrics Society.

[19]  N. Bornstein,et al.  ACE, MTHFR, factor V Leiden, and APOE polymorphisms in patients with vascular and Alzheimer's dementia. , 1998, Stroke.

[20]  D. Hogan,et al.  Folate status, vascular disease and cognition in elderly Canadians. , 1998, Age and ageing.

[21]  A. McCaddon,et al.  Total serum homocysteine in senile dementia of Alzheimer type , 1998, International journal of geriatric psychiatry.

[22]  E. Ringelstein,et al.  Features, symptoms, and neurophysiological findings in stroke associated with hyperhomocysteinemia. , 1997, Archives of neurology.

[23]  E. Lesaffre,et al.  Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[24]  C. Martyn,et al.  Cognitive impairment and mortality in a cohort of elderly people , 1996, BMJ.

[25]  A. Spiro,et al.  Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. , 1996, The American journal of clinical nutrition.

[26]  P. McKeigue,et al.  Resting and ambulatory blood pressure differences in Afro-Caribbeans and Europeans. , 1993, Hypertension.

[27]  M. Breteler.  Cognitive decline in the elderly : epidemiologic studies on cognitive function and dementia , 1993 .

[28]  K. Shulman,et al.  Clock‐drawing and dementia in the community: A longitudinal study , 1993 .

[29]  I. Bell,et al.  Plasma homocysteine in vascular disease and in nonvascular dementia of depressed elderly people , 1992, Acta psychiatrica Scandinavica.

[30]  J. Morris,et al.  The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease , 1989, Neurology.

[31]  L. George,et al.  Relationship of health and demographic characteristics to Mini-Mental State Examination score among community residents , 1988, Psychological Medicine.

[32]  N. R. Schultz,et al.  Clinical significance of cognitive performance by hypertensive patients. , 1987, Hypertension.

[33]  Cyrus R. Mehta,et al.  Computing an Exact Confidence Interval for the Common Odds Ratio in Several 2×2 Contingency Tables , 1985 .

[34]  S. Folstein,et al.  “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician , 1975 .

[35]  D. Fuchs,et al.  Homocysteine and B vitamins in dementia. , 2001, The American journal of clinical nutrition.

[36]  P Pietrini,et al.  Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis. , 1997, The American journal of psychiatry.

[37]  M. Schlossberg.  The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. , 1986 .