European Paediatric Surgeons' Association Survey on the Management of Pediatric Appendicitis

Abstract Aim To define patterns in the management of pediatric appendicitis. Methods A total of 169 delegates from 42 (24 European) countries completed a validated survey administered at the EUPSA 2017 annual congress. Results In the work-up of children with suspected acute appendicitis, most surgeons rely on full blood count (92%), C-reactive protein (82%), and abdominal ultrasonography (76%), but rarely on computed tomography scans or magnetic resonance imaging. In suspected simple appendicitis, most surgeons (76%) do not perform appendectomy at night in clinically stable patients and start antibiotic preoperatively (64%), but only 15% offer antibiotic therapy alone (no appendectomy). In suspected perforated appendicitis, 96% start antibiotic preoperatively, and 92% perform an appendectomy. Presence of phlegmon/abscess is the main contraindication to immediate surgery. In case of appendix mass, most responders (75%) favor a conservative approach and perform interval appendectomy always (56%) or in selected cases (38%) between 2 and 6 months from the first episode (81%). Children with large intraperitoneal abscesses are managed by percutaneous drainage (59% responders) and by surgery (37% responders). Laparoscopy is the preferred surgical approach for both simple (89%) and perforated appendicitis (81%). Most surgeons send the appendix for histology (96%) and pus for microbiology, if present (78%). At the end of the operation, 58% irrigate the abdominal cavity only if contaminated using saline solution (93%). In selected cases, 52% leave a drain in situ. Conclusion Some aspects of appendicitis management lack consensus, particularly appendix mass and intraperitoneal abscess. Evidence-based guidelines should be developed, which may help standardize care and improve clinical outcomes.

[1]  P. Cashin,et al.  Post‐operative telephone review is safe and effective: prospective study – Monash outpatient review by phone trial , 2018, ANZ journal of surgery.

[2]  W. Bemelman,et al.  Imaging in pediatric appendicitis is key to a low normal appendix percentage: a national audit on the outcome of appendectomy for appendicitis in children , 2018, Pediatric Surgery International.

[3]  M. Stringer Acute appendicitis , 2017, Journal of paediatrics and child health.

[4]  S. Eaton,et al.  Current Management of Congenital Pulmonary Airway Malformations: A “European Pediatric Surgeons' Association” Survey , 2017, European Journal of Pediatric Surgery.

[5]  Jamie R. Robinson,et al.  Measuring the Value of a Clinical Practice Guideline for Children With Perforated Appendicitis , 2017, Annals of surgery.

[6]  S. Eaton,et al.  Appendectomy versus non-operative treatment for acute uncomplicated appendicitis in children: study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial , 2017, BMJ Paediatrics Open.

[7]  S. Khurana,et al.  Can common serum biomarkers predict complicated appendicitis in children? , 2017, Pediatric Surgery International.

[8]  S. Eaton,et al.  Active observation versus interval appendicectomy after successful non-operative treatment of an appendix mass in children (CHINA study): an open-label, randomised controlled trial. , 2017, The lancet. Gastroenterology & hepatology.

[9]  B. Slater,et al.  Two-Site Appendectomy in Children: Description of Technique and Outcomes. , 2017, Journal of laparoendoscopic & advanced surgical techniques. Part A.

[10]  J. Karpelowsky,et al.  Acute uncomplicated appendicitis study: rationale and protocol for a multicentre, prospective randomised controlled non-inferiority study to evaluate the safety and effectiveness of non-operative management in children with acute uncomplicated appendicitis , 2016, BMJ Open.

[11]  S. Eaton,et al.  European Paediatric Surgeons' Association Survey on the Management of Hirschsprung Disease , 2016, European Journal of Pediatric Surgery.

[12]  C. Hollenbeak,et al.  Magnetic resonance imaging in pediatric appendicitis: a systematic review , 2016, Pediatric Radiology.

[13]  B. Bucher,et al.  Effect of a Clinical Practice Guideline for Pediatric Complicated Appendicitis. , 2016, JAMA surgery.

[14]  Jennifer N. Cooper,et al.  Effectiveness of Patient Choice in Nonoperative vs Surgical Management of Pediatric Uncomplicated Acute Appendicitis. , 2016, JAMA surgery.

[15]  S. Eaton,et al.  The Value of Surveys in Pediatric Surgery , 2015, European Journal of Pediatric Surgery.

[16]  S. Eaton,et al.  International Survey on the Management of Congenital Diaphragmatic Hernia , 2015, European Journal of Pediatric Surgery.

[17]  B. Hagel,et al.  Variation in the Diagnosis and Management of Appendicitis at Canadian Pediatric Hospitals. , 2015, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[18]  Ra-Yeong Song,et al.  Drain insertion after appendectomy in children with perforated appendicitis based on a single-center experience , 2015, Annals of surgical treatment and research.

[19]  M. Janssen-Heijnen,et al.  Prospective Evaluation of the Added Value of Imaging within the Dutch National Diagnostic Appendicitis Guideline - Do we Forget our Clinical Eye? , 2015, Digestive Surgery.

[20]  H. Janzing,et al.  Does the Use of Diagnostic Imaging Reduce the Rate of Negative Appendectomy ? , 2015, Acta chirurgica Belgica.

[21]  S. Eaton,et al.  International Survey on the Management of Necrotizing Enterocolitis , 2014, European Journal of Pediatric Surgery.

[22]  A. Bhangu Safety of Short, In-Hospital Delays Before Surgery for Acute Appendicitis: Multicentre Cohort Study, Systematic Review, and Meta-Analysis , 2014, Annals of surgery.

[23]  W. Middlesworth,et al.  Ultrasonography/MRI Versus CT for Diagnosing Appendicitis , 2014, Pediatrics.

[24]  Sara C. Fallon,et al.  Modification of an evidence-based protocol for advanced appendicitis in children. , 2013, The Journal of surgical research.

[25]  S. Eaton,et al.  Management of Pediatric Inguinal Hernias in the Era of Laparoscopy: Results of an International Survey , 2013, European Journal of Pediatric Surgery.

[26]  S. Eaton,et al.  International Survey on the Management of Esophageal Atresia , 2013, European Journal of Pediatric Surgery.

[27]  Sheila Weinmann,et al.  The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk. , 2013, JAMA pediatrics.

[28]  G. Mattioli,et al.  Susceptibility to antibiotics of aerobic bacteria isolated from community acquired secondary peritonitis in children: therapeutic guidelines might not always fit with and everyday experience , 2013, Journal of chemotherapy.

[29]  W. S. Russell,et al.  Clinical Practice Guidelines for Pediatric Appendicitis Evaluation Can Decrease Computed Tomography Utilization While Maintaining Diagnostic Accuracy , 2013, Pediatric emergency care.

[30]  Ling-I Juan,et al.  Systematic review and meta‐analysis of the diagnostic accuracy of procalcitonin, C‐reactive protein and white blood cell count for suspected acute appendicitis , 2013, The British journal of surgery.

[31]  Stanley T Kim,et al.  Percutaneous Drainage of Abdominal and Pelvic Abscesses in Children , 2012, Seminars in Interventional Radiology.

[32]  M. Davenport,et al.  Is there Unity in Europe? First Survey of EUPSA Delegates on the Management of Gastroschisis , 2012, European Journal of Pediatric Surgery.

[33]  M. Clarke,et al.  Barriers to the uptake of evidence from systematic reviews and meta-analyses: a systematic review of decision makers’ perceptions , 2012, BMJ Open.

[34]  R. Lewis,et al.  Prospective evaluation of a clinical practice guideline for diagnosis of appendicitis in children. , 2012, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[35]  A. Boddy Increased use of pre-operative imaging and laparoscopy has no impact on clinical outcomes in patients undergoing appendicectomy. , 2012, Annals of the Royal College of Surgeons of England.

[36]  S. S. St. Peter,et al.  Single Incision Versus Standard 3-Port Laparoscopic Appendectomy: A Prospective Randomized Trial , 2011, Annals of Surgery.

[37]  A. Zani,et al.  Flexible-Tip Laparo-Endoscopic Surgery: A Bridge to Single Port Appendicectomy in Children , 2011, European Journal of Pediatric Surgery.

[38]  L. Cassidy,et al.  Antibiotics and appendicitis in the pediatric population: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review. , 2010, Journal of pediatric surgery.

[39]  E. P. Dellinger,et al.  Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[40]  S. S. St. Peter,et al.  An evidence-based definition for perforated appendicitis derived from a prospective randomized trial. , 2008, Journal of pediatric surgery.

[41]  F. Foo,et al.  Intra-operative culture swabs in acute appendicitis: a waste of resources. , 2008, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

[42]  B. Gaines,et al.  The Surgical Infection Society guidelines on antimicrobial therapy for children with appendicitis. , 2008, Surgical infections.

[43]  Azan S Al-Saadi,et al.  Is abandoning routine peritoneal cultures during appendectomy justified? , 2007, Saudi medical journal.

[44]  N. Keeling,et al.  Value of intraoperative abdominal cavity culture in appendicectomy: a retrospective study , 2006, International journal of clinical practice.

[45]  Ara Darzi,et al.  Laparoscopic Versus Open Appendectomy in Children: A Meta-Analysis , 2006, Annals of surgery.

[46]  S. Muehlstedt,et al.  The management of pediatric appendicitis: a survey of North American Pediatric Surgeons. , 2004, Journal of pediatric surgery.

[47]  D. Smink,et al.  Diagnosis of acute appendicitis in children using a clinical practice guideline. , 2004, Journal of pediatric surgery.

[48]  J. Geiger,et al.  Delayed versus immediate surgery in acute appendicitis: do we need to operate during the night? , 2004, Journal of pediatric surgery.

[49]  S. Parsons,et al.  Current practice patterns in the treatment of perforated appendicitis in children. , 2003, Journal of the American College of Surgeons.

[50]  B. Warner,et al.  The sustained impact of an evidenced-based clinical pathway for acute appendicitis. , 2002, Seminars in pediatric surgery.

[51]  C. Burnweit,et al.  Is abdominal cavity culture of any value in appendicitis? , 1998, American journal of surgery.

[52]  D. Fry,et al.  Peritoneal cultures and antibiotic therapy in pediatric perforated appendicitis. , 1994, American journal of surgery.

[53]  P. Puri,et al.  Is it necessary to perform appendicectomy in the middle of the night in children? , 1993, BMJ.

[54]  E. Bradley,et al.  Appendiceal abscess revisited. , 1978, Archives of surgery.

[55]  J. Haller,et al.  Peritoneal drainage versus non-drainage for generalized peritonitis from ruptured appendicitis in children: a prospective study. , 1973, Annals of surgery.

[56]  T. Dr Conservative management of the appendix mass. , 1973 .

[57]  C. Magarey,et al.  Peritoneal drainage and systemic antibiotics after appendicectomy. A prospective trial. , 1971, Lancet.

[58]  Nansheng Cheng,et al.  Abdominal drainage to prevent intra-peritoneal abscess after open appendectomy for complicated appendicitis. , 2018, The Cochrane database of systematic reviews.

[59]  S. Eaton,et al.  Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial. , 2015, Annals of surgery.

[60]  Y. Collin,et al.  Irrigation versus suction alone during laparoscopic appendectomy for perforated appendicitis: a prospective randomized trial. , 2015, Annals of surgery.

[61]  E. M. Knott,et al.  Patient and parental scar assessment after single incision versus standard 3-port laparoscopic appendectomy: long-term follow-up from a prospective randomized trial. , 2014, Journal of pediatric surgery.

[62]  D. Chiang,et al.  'To have...or not to have'. Should computed tomography and ultrasonography be implemented as a routine work-up for patients with suspected acute appendicitis in a regional hospital? , 2008, Annals of the Royal College of Surgeons of England.

[63]  S. Sauerland,et al.  Laparoscopic versus open surgery for suspected appendicitis. , 2002, The Cochrane database of systematic reviews.

[64]  Letter: Outpatient follow-up after appendicectomy. , 1976, The Lancet.

[65]  D. R. Thomas Conservative management of the appendix mass. , 1973, Surgery.