Effects of magnesium sulphuricum combined with low molecular weight heparin sodium on the blood pressure, D-D and hs-CRP levels in patients with severe preeclampsia

Objective: This study aimed to analyze the effects of magnesium sulphuricum combined with low molecular weight heparin sodium on blood pressure, D-dimer (D-D) and high-sensitivity C-reactive protein (hs-CRP) in patients with severe preeclampsia. Methods: A total of 103 patients with severe preeclampsia were analyzed for their clinical data and divided into the control group (CG) for treatment with magnesium sulphuricum and the observation group (OG) for treatment with magnesium sulphuricum and low molecular weight heparin sodium. The 2 groups were compared for diastolic blood pressure (DBP), systolic blood pressure (SBP), 24 h urine protein (PRO), D-D and high-sensitivity C-reactive protein (hs-CRP), number of gestational weeks for pregnancy termination, average treatment duration and complications. Results: After treatment, the SBP, DBP, mean arterial blood pressure (MABP), D-D and hs-CRP levels were lower, the PRO was less, the gestational weeks for pregnancy termination and average treatment duration were shorter in the OG (P<0.05). The incidence of complications was 7.69% (4/52) in the OG and 27.45% (14/51) in the CG (P<0.05). Conclusion: The combination of magnesium sulphuricum and low molecular weight heparin sodium in patients with severe preeclampsia can effectively control blood pressure, improve D-D and hs-CRP levels, inhibit inflammatory reactions and reduce the incidence of complications.

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