Auraptene consolidates memory, reverses scopolamine-disrupted memory in passive avoidance task, and ameliorates retention deficits in mice

Objective(s): Auraptene (7-geranyloxycoumarin) (AUR), from Citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (AChE) and beta-secretase inhibitory effects. Scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of Alzheimer’s disease (AD). This research aimed to investigate the effect of AUR on scopolamine-induced avoidance memory retention deficits in step-through task in mice. Materials and Methods: The effect of four-day pre-training injections of AUR (50, 75, and 100 mg/kg, subcutaneous (SC)) and scopolamine (1 mg/kg, IP), and their co-administration on avoidance memory retention in step-through passive avoidance task, was investigated by measuring the latency to enter to the dark chamber. Results: Pre-training administration of AUR caused significant increase in step-through latency in comparison with control group, 48, 96, and 168 hr after training trial. The findings of this study showed that scopolamine (1 mg/kg, IP, for four consecutive days) impaired passive avoidance memory retention compared to saline-treated animals. Step-through passive avoidance task results showed that AUR markedly reversed scopolamine-induced avoidance memory retention impairments, 24 and 168 hr after training trial in step-through task. Conclusion: Results from co-administration of AUR and scopolamine showed that AUR reversed scopolamine-induced passive avoidance memory retention impairments.

[1]  B. Razavi,et al.  Antihypertensive effect of auraptene, a monoterpene coumarin from the genus Citrus, upon chronic administration , 2015, Iranian journal of basic medical sciences.

[2]  P. Agostinho,et al.  Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats , 2014, International Journal of Developmental Neuroscience.

[3]  M. Iranshahi,et al.  Cytotoxic activities of phytochemicals from Ferula species , 2013, DARU Journal of Pharmaceutical Sciences.

[4]  M. Iranshahi,et al.  Hypotensive activity of auraptene, a monoterpene coumarin from Citrus spp. , 2013, Pharmaceutical biology.

[5]  N. Shimada,et al.  Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice. , 2013, European journal of pharmacology.

[6]  M. Iranshahi,et al.  Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors. , 2012, European journal of medicinal chemistry.

[7]  S. Okuyama,et al.  Neurotrophic Effect of Citrus Auraptene: Neuritogenic Activity in PC12 Cells , 2012, International journal of molecular sciences.

[8]  S. Okuyama,et al.  Isolation and Characterization of Activators of ERK/MAPK from Citrus Plants , 2012, International journal of molecular sciences.

[9]  M. Miyazawa,et al.  Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor. , 2012, Bioorganic & medicinal chemistry.

[10]  A. Moghimi,et al.  THE EFFECT OF SCOPOLAMINE ON AVOIDANCE MEMORY AND HIPPOCAMPAL NEURONS IN MALE WISTAR RATS , 2011 .

[11]  M. Iranshahi,et al.  Biologically active sesquiterpene coumarins from Ferula species , 2011, Phytotherapy research : PTR.

[12]  A. Blokland,et al.  A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment , 2011, Psychopharmacology.

[13]  K. Bystricky,et al.  Auraptene Is an Inhibitor of Cholesterol Esterification and a Modulator of Estrogen Receptors , 2010, Molecular Pharmacology.

[14]  M. Zarrindast,et al.  Involvement of dorsal hippocampal α-adrenergic receptors in the effect of scopolamine on memory retrieval in inhibitory avoidance task , 2010, Neurobiology of Learning and Memory.

[15]  M. Miyazawa,et al.  β‐secretase inhibitory effects of furanocoumarins from the root of Angelica dahurica , 2010, Phytotherapy research : PTR.

[16]  J. Behravan,et al.  Auraptene from Ferula szowitsiana protects human peripheral lymphocytes against oxidative stress , 2010, Phytotherapy research : PTR.

[17]  M. Iranshahi,et al.  Screening of Acetylcholinesterase Inhibitory Activity of Terpenoid and Coumarin Derivatives from the Genus Ferula , 2010 .

[18]  A. Sahebkar,et al.  Synthesis and Purification of 7-Prenyloxycoumarins and Herniarin as Bioactive Natural Coumarins , 2009 .

[19]  S. Genovese,et al.  Neuroprotective effect of prenyloxycoumarins from edible vegetables , 2008, Neuroscience Letters.

[20]  R. Shin,et al.  Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Aβ Pathology in a Transgenic Mouse Model of Alzheimer's Disease , 2008, Journal of Pharmacology and Experimental Therapeutics.

[21]  R. Tundis,et al.  Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update. , 2008, Current medicinal chemistry.

[22]  Chihiro Ito,et al.  Cancer chemopreventive activity of terpenoid coumarins from Ferula species. , 2008, Planta medica.

[23]  F. Crews,et al.  Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration , 2007, Glia.

[24]  M. Zarrindast,et al.  Influence of cholinergic system modulators on morphine state-dependent memory of passive avoidance in mice , 2006, Physiology & Behavior.

[25]  K. J. Murphy,et al.  Chronic Exposure of Rats to Cognition Enhancing Drugs Produces a Neuroplastic Response Identical to that Obtained by Complex Environment Rearing , 2006, Neuropsychopharmacology.

[26]  P. Mcgeer,et al.  Inflammation, the complement system and the diseases of aging , 2005, Neurobiology of Aging.

[27]  M. Sharifzadeh,et al.  Post‐training intrahippocampal infusion of nicotine prevents spatial memory retention deficits induced by the cyclo‐oxygenase‐2‐specific inhibitor celecoxib in rats , 2005, Journal of neurochemistry.

[28]  Malcolm W. Brown,et al.  Cholinergic Neurotransmission Is Essential for Perirhinal Cortical Plasticity and Recognition Memory , 2003, Neuron.

[29]  M. Miyazawa,et al.  Inhibition of Acetylcholinesterase Activity by Essential Oil from Citrus paradisi , 2001, Natural product letters.

[30]  P. Isakson,et al.  Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[31]  E. Kandel,et al.  Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. , 1993, Science.