Dendritic Tau in Alzheimer’s Disease

[1]  N. Dokholyan,et al.  Faculty of 1000 evaluation for Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. , 2018 .

[2]  P. Verstreken,et al.  Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau , 2018, Neuron.

[3]  A. Ittner,et al.  An N-terminal motif unique to primate tau enables differential protein–protein interactions , 2018, The Journal of Biological Chemistry.

[4]  J. Götz,et al.  Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn‐mediated local protein translation , 2017, The EMBO journal.

[5]  A. Bush,et al.  Tau-mediated iron export prevents ferroptotic damage after ischemic stroke , 2017, Molecular Psychiatry.

[6]  T. Fath,et al.  Tau exacerbates excitotoxic brain damage in an animal model of stroke , 2017, Nature Communications.

[7]  P. Kwan,et al.  Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice , 2017, Epilepsia.

[8]  L. Buée,et al.  Tau deletion promotes brain insulin resistance , 2017, The Journal of experimental medicine.

[9]  A. Palmeri,et al.  LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent , 2017, eLife.

[10]  F. LaFerla,et al.  Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony , 2017, Trends in Neurosciences.

[11]  E. Mandelkow,et al.  Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture , 2017, The Journal of Biological Chemistry.

[12]  K. Vossel,et al.  Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture , 2017, Molecular Neurodegeneration.

[13]  A. Takashima,et al.  Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation , 2017, EBioMedicine.

[14]  Rosemary J. Jackson,et al.  Tau association with synaptic vesicles causes presynaptic dysfunction , 2017, Nature Communications.

[15]  A. Van der Jeugd,et al.  Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model , 2017, Brain : a journal of neurology.

[16]  M. Schubert,et al.  Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease , 2017, Nature Communications.

[17]  Timothy A. Miller,et al.  Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy , 2017, Science Translational Medicine.

[18]  D. Xia,et al.  Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment , 2017, Acta Neuropathologica.

[19]  E. Mandelkow,et al.  Additional file 5: Figure S5. of The release and trans-synaptic transmission of Tau via exosomes , 2017 .

[20]  A. Ittner.  SITE-SPECIFIC PHOSPHORYLATION OF TAU INHIBITS AMYLOID-β TOXICITY IN ALZHEIMER’S MICE , 2016, Alzheimer's & Dementia.

[21]  A. Bongers,et al.  No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice , 2016, PloS one.

[22]  K. Zahs,et al.  Caspase-2 cleavage of tau reversibly impairs memory , 2016, Nature Medicine.

[23]  A. Prokop,et al.  Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking , 2016, eLife.

[24]  K. Blennow,et al.  Alzheimer's disease , 2016, The Lancet.

[25]  J. Götz,et al.  Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau , 2016, Scientific Reports.

[26]  J. Jankowsky,et al.  Amyloid-β plaques disrupt axon initial segments , 2016, Experimental Neurology.

[27]  L. Grinberg,et al.  Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment , 2016, Molecular Neurodegeneration.

[28]  M. Czisch,et al.  Tau protein is essential for stress-induced brain pathology , 2016, Proceedings of the National Academy of Sciences.

[29]  S. A. Hussaini,et al.  Neuronal activity enhances tau propagation and tau pathology in vivo , 2016, Nature Neuroscience.

[30]  W. Noble,et al.  Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease , 2016, Acta neuropathologica communications.

[31]  R. Huganir,et al.  Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss , 2016, Neuron.

[32]  B. Hyman,et al.  Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity , 2015, The EMBO journal.

[33]  E. Mandelkow,et al.  Tau in physiology and pathology , 2015, Nature Reviews Neuroscience.

[34]  E. Mandelkow,et al.  Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia , 2015, Molecular Neurodegeneration.

[35]  N. Mons,et al.  Altered hippocampal information coding and network synchrony in APP-PS1 mice , 2015, Neurobiology of Aging.

[36]  H. Wood.  Alzheimer disease: Evidence for trans-synaptic and exo-synaptic tau propagation in Alzheimer disease , 2015, Nature Reviews Neurology.

[37]  B. Hyman,et al.  Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain , 2015, Nature Communications.

[38]  Jennifer Luebke,et al.  Depletion of microglia and inhibition of exosome synthesis halt tau propagation , 2015, Nature Neuroscience.

[39]  Michel Goedert,et al.  Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein , 2015, Science.

[40]  D. Selkoe,et al.  C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death , 2015, The Journal of Neuroscience.

[41]  M. Vassalli,et al.  HDAC6 and RhoA are novel players in Abeta-driven disruption of neuronal polarity , 2015, Nature Communications.

[42]  Meaghan Morris,et al.  Tau post-translational modifications in wildtype and human amyloid precursor protein transgenic mice , 2015, Nature Neuroscience.

[43]  L. Buée,et al.  Regulation of human MAPT gene expression , 2015, Molecular Neurodegeneration.

[44]  P. Verstreken,et al.  Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. , 2015, Cell reports.

[45]  D. Xia,et al.  Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines. , 2015, Biochimica et biophysica acta.

[46]  M. Macavoy,et al.  A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer’s disease , 2015, Alzheimer's Research & Therapy.

[47]  G. Bormans,et al.  Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice , 2015, Acta Neuropathologica.

[48]  M. Frotscher,et al.  Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation , 2015, Acta Neuropathologica Communications.

[49]  Se Jin Park,et al.  Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD , 2015, The Journal of Neuroscience.

[50]  Urmi Sengupta,et al.  Tau Immunotherapy Modulates Both Pathological Tau and Upstream Amyloid Pathology in an Alzheimer's Disease Mouse Model , 2015, The Journal of Neuroscience.

[51]  B. Hyman,et al.  Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease , 2015, Acta neuropathologica communications.

[52]  A. Ittner,et al.  Tau‐targeting passive immunization modulates aspects of pathology in tau transgenic mice , 2015, Journal of neurochemistry.

[53]  L. Mucke,et al.  Tau Reduction Diminishes Spatial Learning and Memory Deficits after Mild Repetitive Traumatic Brain Injury in Mice , 2014, PloS one.

[54]  Susanne Schoch,et al.  Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease , 2014, Neuron.

[55]  D. Kretzschmar,et al.  Loss of tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila , 2014, Developmental neurobiology.

[56]  N. Sousa,et al.  Selective impact of Tau loss on nociceptive primary afferents and pain sensation , 2014, Experimental Neurology.

[57]  R. D'Hooge,et al.  Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion , 2014, Neurobiology of Aging.

[58]  A. Ittner,et al.  p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer’s disease , 2014, Acta neuropathologica communications.

[59]  B. Hyman,et al.  Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease , 2014, Acta neuropathologica communications.

[60]  D. Ferriero,et al.  NR2B Phosphorylation at Tyrosine 1472 Contributes to Brain Injury in a Rodent Model of Neonatal Hypoxia-Ischemia , 2014, Stroke.

[61]  Nigel J. Cairns,et al.  Proteopathic tau seeding predicts tauopathy in vivo , 2014, Proceedings of the National Academy of Sciences.

[62]  M. Goedert,et al.  Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies , 2014, Current Neurology and Neuroscience Reports.

[63]  William T. Hu,et al.  Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease , 2014, Nature Medicine.

[64]  A. Bush,et al.  Motor and cognitive deficits in aged tau knockout mice in two background strains , 2014, Molecular Neurodegeneration.

[65]  L. Mucke,et al.  Tau Reduction Prevents Disease in a Mouse Model of Dravet Syndrome , 2014, Annals of neurology.

[66]  Qingxiu Zhang,et al.  PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia , 2014, Neurobiology of Disease.

[67]  N. Krogan,et al.  Critical Role of Acetylation in Tau-Mediated Neurodegeneration and Cognitive Deficits , 2015, Nature Medicine.

[68]  A. Buisson,et al.  Activity-Dependent Tau Protein Translocation to Excitatory Synapse Is Disrupted by Exposure to Amyloid-Beta Oligomers , 2014, The Journal of Neuroscience.

[69]  Janna H. Neltner,et al.  Is synaptic loss a unique hallmark of Alzheimer's disease? , 2014, Biochemical pharmacology.

[70]  R. Huganir,et al.  Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer‐induced AMPA glutamate receptor signaling deficits , 2014, The European journal of neuroscience.

[71]  F. LaFerla,et al.  Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease , 2014, Neurobiology of Disease.

[72]  T. Golde,et al.  Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease , 2014, The Journal of Neuroscience.

[73]  J. Sontag,et al.  Protein phosphatase 2A dysfunction in Alzheimer’s disease , 2014, Front. Mol. Neurosci..

[74]  J. Rawlins,et al.  Hippocampal synaptic plasticity, spatial memory and anxiety , 2014, Nature Reviews Neuroscience.

[75]  W. Regehr,et al.  Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release. , 2014, Annual review of physiology.

[76]  M. Sastre,et al.  Modulation of inflammation in transgenic models of Alzheimer’s disease , 2014, Journal of Neuroinflammation.

[77]  J. Winderickx,et al.  Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies , 2014, Acta neuropathologica communications.

[78]  G. Collingridge,et al.  Microtubule-associated protein tau is essential for long-term depression in the hippocampus , 2014, Philosophical Transactions of the Royal Society B: Biological Sciences.

[79]  D. Holtzman,et al.  Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo , 2013, Neuron.

[80]  M. Blackledge,et al.  Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2. , 2013, Biochemistry.

[81]  M. Goedert,et al.  Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice , 2013, Acta neuropathologica communications.

[82]  E. Mandelkow,et al.  Amyloid‐β oligomers induce synaptic damage via Tau‐dependent microtubule severing by TTLL6 and spastin , 2013, The EMBO journal.

[83]  T. Südhof,et al.  Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle , 2013, Neuron.

[84]  D. Holtzman,et al.  Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo , 2013, Neuron.

[85]  J. Serratosa,et al.  Hyperexcitability and epileptic seizures in a model of frontotemporal dementia , 2013, Neurobiology of Disease.

[86]  Casey Cook,et al.  Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance , 2013, Human molecular genetics.

[87]  J. Trojanowski,et al.  Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies , 2013, Nature Reviews Neuroscience.

[88]  D. Holtzman,et al.  Antisense Reduction of Tau in Adult Mice Protects against Seizures , 2013, The Journal of Neuroscience.

[89]  Jesse Jackson,et al.  Alterations in hippocampal network oscillations and theta–gamma coupling arise before Aβ overproduction in a mouse model of Alzheimer's disease , 2013, The European journal of neuroscience.

[90]  Meaghan Morris,et al.  Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice , 2013, Neurobiology of Aging.

[91]  Qiang Zhou,et al.  NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease , 2013, Nature Reviews Neuroscience.

[92]  S. Lovestone,et al.  The Importance of Tau Phosphorylation for Neurodegenerative Diseases , 2013, Front. Neurol..

[93]  I. Grundke‐Iqbal,et al.  Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease* , 2013, The Journal of Biological Chemistry.

[94]  V. Lee,et al.  The microtubule-associated tau protein has intrinsic acetyltransferase activity , 2013, Nature Structural &Molecular Biology.

[95]  R. Nitsch,et al.  NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss , 2013, Cell Death and Disease.

[96]  R. Sadoul,et al.  Exosomes as a novel way of interneuronal communication. , 2013, Biochemical Society transactions.

[97]  S. Younkin,et al.  Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy , 2013, The Journal of Neuroscience.

[98]  F. Kirchhoff,et al.  Microglia: New Roles for the Synaptic Stripper , 2013, Neuron.

[99]  D. Bennett,et al.  The Complex PrPc-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease , 2012, The Journal of Neuroscience.

[100]  Gavin Rumbaugh,et al.  Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses , 2012, Cell.

[101]  B. Hyman,et al.  The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. , 2012, The American journal of pathology.

[102]  C. Parsons,et al.  Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine – searching for the connections , 2012, British journal of pharmacology.

[103]  N. Leclerc,et al.  Interaction of Endogenous Tau Protein with Synaptic Proteins Is Regulated by N-Methyl-d-aspartate Receptor-dependent Tau Phosphorylation* , 2012, The Journal of Biological Chemistry.

[104]  A. Vortmeyer,et al.  Alzheimer Amyloid-β Oligomer Bound to Post-Synaptic Prion Protein Activates Fyn to Impair Neurons , 2012, Nature Neuroscience.

[105]  L. Mucke,et al.  Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. , 2012, Cold Spring Harbor perspectives in medicine.

[106]  E. Mandelkow,et al.  Biochemistry and cell biology of tau protein in neurofibrillary degeneration. , 2012, Cold Spring Harbor perspectives in medicine.

[107]  C. Brosnan,et al.  Mice Devoid of Tau Have Increased Susceptibility to Neuronal Damage in Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis , 2012, Journal of neuropathology and experimental neurology.

[108]  Bernardo L Sabatini,et al.  Synapses and Alzheimer's disease. , 2012, Cold Spring Harbor perspectives in biology.

[109]  Edward O. Mann,et al.  Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model , 2012, Cell.

[110]  Robert Weissert.  Experimental Autoimmune Encephalomyelitis , 2012 .

[111]  B. Ghetti,et al.  Frontotemporal dementia: implications for understanding Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.

[112]  Blaine R. Roberts,et al.  Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export , 2012, Nature Medicine.

[113]  E. Mandelkow,et al.  Linking Amyloid-β and Tau: Amyloid-β Induced Synaptic Dysfunction via Local Wreckage of the Neuronal Cytoskeleton , 2011, Neurodegenerative Diseases.

[114]  M. Sheng,et al.  The postsynaptic organization of synapses. , 2011, Cold Spring Harbor perspectives in biology.

[115]  E. Mandelkow,et al.  Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration , 2011, The EMBO journal.

[116]  Stefani N. Thomas,et al.  Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach , 2011, Acta Neuropathologica.

[117]  S. Kügler,et al.  Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. , 2011, The American journal of pathology.

[118]  B. Hyman,et al.  Neuropathological alterations in Alzheimer disease. , 2011, Cold Spring Harbor perspectives in medicine.

[119]  R. Huganir,et al.  Regulation of AMPA Receptor Function by the Human Memory-Associated Gene KIBRA , 2011, Neuron.

[120]  C. Catania,et al.  Stress Acts Cumulatively To Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits , 2011, The Journal of Neuroscience.

[121]  J. Trojanowski,et al.  The acetylation of tau inhibits its function and promotes pathological tau aggregation. , 2011, Nature communications.

[122]  G. Drewes,et al.  The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2–dependent manner , 2011, The Journal of cell biology.

[123]  Jürgen Götz,et al.  Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease , 2011, Nature Reviews Neuroscience.

[124]  Ezzie Hutchinson,et al.  Systems neuroscience: The stress of dieting , 2011, Nature Reviews Neuroscience.

[125]  L. Mucke,et al.  Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease , 2011, The Journal of Neuroscience.

[126]  K. Ashe,et al.  Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration , 2010, Neuron.

[127]  D. Quartermain,et al.  Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model , 2010, The Journal of Neuroscience.

[128]  V. Haroutunian,et al.  Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy , 2010, Neuron.

[129]  H. Bading,et al.  Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders , 2010, Nature Reviews Neuroscience.

[130]  V. Haroutunian,et al.  Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy , 2010, Neuron.

[131]  E. Mandelkow,et al.  Aβ Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines , 2010, The Journal of Neuroscience.

[132]  Jürgen Götz,et al.  Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models , 2010, Cell.

[133]  Matthew N. Rasband,et al.  The axon initial segment and the maintenance of neuronal polarity , 2010, Nature Reviews Neuroscience.

[134]  L. Mucke,et al.  Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks , 2010, Nature Neuroscience.

[135]  K. Herrup.  Faculty Opinions recommendation of Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau. , 2009 .

[136]  R. Brandt,et al.  Divergent Pathways Mediate Spine Alterations and Cell Death Induced by Amyloid-β, Wild-Type Tau, and R406W Tau , 2009, The Journal of Neuroscience.

[137]  Cheng-Hsien Lu,et al.  Elevated basal cortisol level predicts lower hippocampal volume and cognitive decline in Alzheimer’s disease , 2009, Journal of Clinical Neuroscience.

[138]  Bradley T. Hyman,et al.  Tau pathophysiology in neurodegeneration: a tangled issue , 2009, Trends in Neurosciences.

[139]  C. Hoogenraad,et al.  Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity , 2009, Neuron.

[140]  T. Ben-Hur,et al.  A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics , 2008, Experimental Neurology.

[141]  Anatol C. Kreitzer,et al.  Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease , 2007, Neuron.

[142]  J. Trojanowski,et al.  Tau-mediated neurodegeneration in Alzheimer's disease and related disorders , 2007, Nature Reviews Neuroscience.

[143]  L. Mucke,et al.  Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model , 2007, Science.

[144]  F. LaFerla,et al.  Pathways by which Abeta facilitates tau pathology. , 2006, Current Alzheimer research.

[145]  T. Matthews,et al.  Site-specific Phosphorylation and Caspase Cleavage Differentially Impact Tau-Microtubule Interactions and Tau Aggregation* , 2006, Journal of Biological Chemistry.

[146]  R. Huganir,et al.  SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[147]  S. Yen,et al.  Disease-related Modifications in Tau Affect the Interaction between Fyn and Tau* , 2005, Journal of Biological Chemistry.

[148]  L. Mucke,et al.  Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease , 2005, The Journal of Neuroscience.

[149]  Masahiko Watanabe,et al.  Fyn kinase‐mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain , 2005, The European journal of neuroscience.

[150]  F. van Leuven,et al.  Changed Conformation of Mutant Tau-P301L Underlies the Moribund Tauopathy, Absent in Progressive, Nonlethal Axonopathy of Tau-4R/2N Transgenic Mice* , 2005, Journal of Biological Chemistry.

[151]  G. Schellenberg,et al.  Regulation of tau isoform expression and dementia. , 2005, Biochimica et biophysica acta.

[152]  M. Courtney,et al.  The PSD95–nNOS interface , 2005, The Journal of cell biology.

[153]  S. Halpain,et al.  The MAP2/Tau family of microtubule-associated proteins , 2004, Genome Biology.

[154]  M. Sheng,et al.  PDZ domain proteins of synapses , 2004, Nature Reviews Neuroscience.

[155]  M. Goedert,et al.  Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2. , 2004, The Biochemical journal.

[156]  M. Tymianski,et al.  Molecular mechanisms underlying specificity of excitotoxic signaling in neurons. , 2004, Current molecular medicine.

[157]  S. J. Martin,et al.  SynGAP Regulates ERK/MAPK Signaling, Synaptic Plasticity, and Learning in the Complex with Postsynaptic Density 95 and NMDA Receptor , 2002, The Journal of Neuroscience.

[158]  Yitao Liu,et al.  Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions , 2002, Science.

[159]  M. Vitek,et al.  Tau is essential to β-amyloid-induced neurotoxicity , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[160]  M. Baudry,et al.  Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD‐95 , 2001, Journal of neurochemistry.

[161]  R. Nitsch,et al.  Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils , 2001, Science.

[162]  J. Hardy,et al.  Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP , 2001, Science.

[163]  M. Vitek,et al.  Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. , 2001, Journal of cell science.

[164]  Patrick R. Hof,et al.  Tau protein isoforms, phosphorylation and role in neurodegenerative disorders 1 1 These authors contributed equally to this work. , 2000, Brain Research Reviews.

[165]  D. Muller,et al.  Decreased Protein Phosphatase 2A Activity in Hippocampal Long‐Term Potentiation , 2000, Journal of neurochemistry.

[166]  I. Mellman,et al.  A diffusion barrier maintains distribution of membrane proteins in polarized neurons , 1999, Nature.

[167]  W. Blackstock,et al.  New Phosphorylation Sites Identified in Hyperphosphorylated Tau (Paired Helical Filament‐Tau) from Alzheimer's Disease Brain Using Nanoelectrospray Mass Spectrometry , 1998, Journal of neurochemistry.

[168]  H. Band,et al.  Tau interacts with src-family non-receptor tyrosine kinases. , 1998, Journal of cell science.

[169]  G. Bloom,et al.  Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A , 1996, Neuron.

[170]  I. Grundke‐Iqbal,et al.  Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases. , 1996, Archives of biochemistry and biophysics.

[171]  N. Hirokawa,et al.  Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons , 1996, The Journal of cell biology.

[172]  H. Braak,et al.  Staging of alzheimer's disease-related neurofibrillary changes , 1995, Neurobiology of Aging.

[173]  M. Goedert,et al.  Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. , 1995, The EMBO journal.

[174]  E. Mandelkow,et al.  Microtubule-associated Protein/Microtubule Affinity-regulating Kinase (p110mark) , 1995, The Journal of Biological Chemistry.

[175]  G. Collingridge,et al.  The NMDA Receptor , 1995 .

[176]  N. Hirokawa,et al.  Sorting mechanisms of Tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding , 1995, Neuron.

[177]  K. Titani,et al.  Proline-directed and Non-proline-directed Phosphorylation of PHF-tau (*) , 1995, The Journal of Biological Chemistry.

[178]  N. Hirokawa,et al.  Altered microtubule organization in small-calibre axons of mice lacking tau protein , 1994, Nature.

[179]  H. Wiśniewski,et al.  Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences , 1987, Acta Neuropathologica.

[180]  A. Ittner,et al.  Generation of a New Tau Knockout (tauΔex1) Line Using CRISPR/Cas9 Genome Editing in Mice. , 2018, Journal of Alzheimer's disease : JAD.

[181]  Jürgen Götz,et al.  Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies , 2018, Nature Reviews Neurology.

[182]  G. Bloom,et al.  Extracellular Tau Oligomers Induce Invasion of Endogenous Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction. , 2017, Journal of Alzheimer's disease : JAD.

[183]  M. Goedert.  Alzheimer ’ s and Parkinson ’ s diseases : The prion concept in relation to assembled A b , tau , and a-synuclein , 2016 .

[184]  B. Dubois,et al.  A phase II trial of tideglusib in Alzheimer's disease. , 2015, Journal of Alzheimer's disease : JAD.

[185]  阿部 哲也.  Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain , 2006 .

[186]  R. Malenka,et al.  AMPA receptor trafficking and synaptic plasticity. , 2002, Annual review of neuroscience.

[187]  Y. Barde,et al.  Neurotrophins are required for nerve growth during development , 2001, Nature Neuroscience.

[188]  W. Kukull,et al.  Cognitive decline in Alzheimer's disease , 1995 .