Norepinephrine in Urine and Plasma Following Provocative Maneuvers in Normal and Hypertensive Subjects

SUMMARY Urinary norepinephrine (UNE) excretion rate and venous plasma norepinephrine (PNE) concentrations were studied in 266 normotensive and 107 essential hypertensive men and women under conditions of volume expansion with 2 liters of intravenous normal saline over 4 hours, and volume contraction with a 10 mEq sodium diet and 120 mg oral furosemide. The UNE excretion rate was correlated with age in normal women only. In men, and in hypertensives of both sexes, the relationship appeared to be biphasic. The PNE concentration was not correlated with age in the hypertensive subjects. Insufficient numbers of older subjects were available to exclude absolutely such a relationship among normals. The UNE and PNE were influenced by volume expansion and contraction in both normals and hypertensives; however, normals exhibited a correlation between UNE and blood pressure as well as consistent correlations between UNE and PNE, neither of which were observed in the hypertensives. Hypertensive women generally had greater UNE and PNE values than normal women or hypertensive men. Hypertensive women may have altered sympathetic activity.

[1]  M. Nassif.  [Arterial pressure regulation]. , 1979, Arquivos brasileiros de cardiologia.

[2]  N. Fineberg,et al.  Responses to Volume Expansion and Contraction in Categorized Hypertensive and Normotensive Man , 1979, Hypertension.

[3]  M. Weinberger,et al.  Vascular compartmentalization of plasma norepinephrine in normal man: the relationships between venous and arterial norepinephrine concentration and the urinary excretion of norepinephrine. , 1979, The Journal of laboratory and clinical medicine.

[4]  A. Weyman,et al.  Plasma and Urinary Norepinephrine Values at Extremes of Sodium Intake in Normal Man , 1979, Hypertension.

[5]  N. Fineberg,et al.  Effects of Volume Expansion and Contraction in Normotensive Whites, Blacks, and Subjects of Different Ages , 1979, Circulation.

[6]  R. Holle,et al.  A composite analysis of renin classification methods. , 1978, Archives of internal medicine.

[7]  J. de Champlain,et al.  Lack of correlation between age and circulating catecholamines in hypertensive patients. , 1977, The New England journal of medicine.

[8]  D. Robertson.  Hypertension and the sympathetic nervous system. , 1977, Journal of the Tennessee Medical Association.

[9]  P. Sever,et al.  PLASMA-NORADRENALINE IN ESSENTIAL HYPERTENSION , 1977, The Lancet.

[10]  M. Weinberger,et al.  Diagnosis of secondary forms of hypertension. A comprehensive protocol. , 1977, JAMA.

[11]  S. Julius,et al.  Mild high-renin essential hypertension. Neurogenic human hypertension? , 1977, The New England journal of medicine.

[12]  P. Weidmann,et al.  Interrelations among blood pressure, blood volume, plasma renin activity and urinary catecholamines in benign essential hypertension. , 1977, The American journal of medicine.

[13]  I. Kopin,et al.  Age-adjusted plasma norepinephrine levels are similar in normotensive and hypertensive subjects. , 1977, The New England journal of medicine.

[14]  J. Cuche,et al.  An increase in urinary catecholamines of renal origin in patients with “borderline” hypertension , 1976, The American journal of the medical sciences.

[15]  D. Adams,et al.  The renal circulation in hypertensive disease. , 1976, The American journal of medicine.

[16]  J. de Champlain,et al.  Circulating Catecholamine Levels in Human and Experimental Hypertension , 1976, Circulation research.

[17]  N. Christensen,et al.  Catecholamines in plasma and urine in patients with essential hypertension determined by double-isotope derivative techniques. , 2009, Acta medica Scandinavica.

[18]  G. Tibblin,et al.  Urinary noradrenaline excretion and renal function in normal and hypertensive 50-year-old men. , 1975, Clinical science and molecular medicine.

[19]  C. A. Nugent,et al.  The effect of dexamethasone on the control of plasma aldosterone concentration in normal recumbent man. , 1975, The Journal of laboratory and clinical medicine.

[20]  D. Johnson,et al.  A sensitive radioenzymatic assay for norepinephrine in tissues and plasma. , 1975, Life sciences.

[21]  N. Nie.  SPSS: statistical package for the social sciences , 1975 .

[22]  A. Barbeau,et al.  Sex differences in the urinary catecholamines. , 1975, Endocrine research communications.

[23]  G. W. Liddle,et al.  Prolonged alteration of renin responsiveness after spironolactone therapy. A cause of false-negative testing for low-renin hypertension. , 1974, The New England journal of medicine.

[24]  A. Barbeau,et al.  Autonomic Nervous System and Benign Essential Hypertension in Man: I. Usual Blood Pressure, Catecholamines, Renin, and their Interrelationships , 1974 .

[25]  W. Lovenberg,et al.  Effects of dietary sodium and of acute saline infusion on the interrelationship between dopamine excretion and adrenergic activity in man. , 1974, The Journal of clinical investigation.

[26]  V. Dequattro,et al.  Neurogenic factors in human hypertension: mechanism or myth? , 1973, The American journal of medicine.

[27]  W. Louis,et al.  Plasma norepinephrine levels in essential hyoertension. , 1973, The New England journal of medicine.

[28]  R. A. Norman,et al.  Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. , 1972, The American journal of medicine.

[29]  V. Dequattro,et al.  Raised plasma-catecholamines in some patients with primary hypertension. , 1972, Lancet.

[30]  J. Laragh,et al.  Essential hypertension: renin and aldosterone, heart attack and stroke. , 1972, The New England journal of medicine.

[31]  C. A. Nugent,et al.  Saline suppression of plasma aldosterone in hypertension. , 1971, Archives of internal medicine.

[32]  K Engelman,et al.  V. CATECHOLAMINES CYCLIC AMP‐ANGIOTENSIN RECEPTORS: Plasma Catecholamine Concentrations in Patients with Hypertension , 1970, Circulation research.

[33]  J. T. Shepherd,et al.  Autonomic control of the peripheral vascular system. , 1970, Archives of internal medicine.

[34]  R. L. Wolf,et al.  Catecholamine metabolism in essential hypertension. , 1970, American heart journal.

[35]  M. Weinberger,et al.  Hypertension induced by oral contraceptives containing estrogen and gestagen. Effects on plasma renin activity and aldosterone excretion. , 1969, Annals of internal medicine.

[36]  Nestel Pj,et al.  The excretion of free noradrenaline and adrenaline by healthy young subjects and by patients with essential hypertension. , 1968 .

[37]  A. Sjoerdsma,et al.  Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs. , 1968, The Journal of clinical investigation.

[38]  J. Axelrod,et al.  Abnormal Storage of Norepinephrine in Experimental Hypertension in the Rat , 1967, Circulation research.

[39]  T. Ikoma.  Studies on Catechols with Reference to Hypertension : Report II , 1965 .

[40]  T. Ikoma.  Studies on catechols with reference to hypertension. II. , 1965, Japanese circulation journal.

[41]  T. Ikoma.  Studies on catechols with reference to hypertension. I. , 1965, Japanese circulation journal.

[42]  S. Brunjes.  CATECHOL AMINE METABOLISM IN ESSENTIAL HYPERTENSION. , 1964, The New England journal of medicine.

[43]  P. Serrano,et al.  ADRENALINE, NORADRENALINE AND DOPAMINE EXCRETION IN PATIENTS WITH ESSENTIAL HYPERTENSION. , 1964, The American journal of cardiology.

[44]  M. Goodall,et al.  Essential hypertension with an elevated noradrenaline excretion. , 1961, American heart journal.

[45]  A. Sjoerdsma,et al.  Urinary excretion of catecholamines and their metabolites in pheochromocytoma. , 1961, American heart journal.

[46]  K. Yoshinaga,et al.  Studies on the role of noradrenaline in the pathogenesis of hypertension. , 1960, The Tohoku journal of experimental medicine.

[47]  F. Sunderman,et al.  A METHOD FOR THE DETERMINATION OF 3-METHOXY-4- HYDROXYMANDELIC ACID ("VANILMANDELIC ACID") FOR THE DIAGNOSIS OF PHEOCHROMOCYTOMA , 1960 .

[48]  W. J. Griffiths,et al.  The Estimation of Noradrenaline in Urine and Its Excretion in Normal and Hypertensive Subjects , 1957, Journal of clinical pathology.

[49]  P. Møller,et al.  Blood pressure and urinary excretion of nor-adrenaline (NA). , 1957, Scandinavian journal of clinical and laboratory investigation.

[50]  L. Plantin,et al.  Studies on the adrenocortical, adreno-medullary and adrenergic nerve activity in essential hypertension. , 1957, Zeitschrift fur Vitamin-, Hormon- und Fermentforschung.

[51]  A. Pekkarinen,et al.  Noradrenaline and adrenaline in the urine. II. Their excretion in certain normal and pathological conditions. , 1955, Scandinavian journal of clinical and laboratory investigation.

[52]  M. Goldenberg.  Chemical Screening Methods for the Diagnosis of Phæochromocytoma , 1954 .

[53]  M. Rapport,et al.  Chemical screening methods for the diagnosis of pheochromocytoma. I. Nor-epinephrine and epinephrine in human urine. , 1954, The American journal of medicine.

[54]  U. V. von Euler,et al.  Excretion of noradrenaline in urine in hypertension. , 1954, Scandinavian journal of clinical and laboratory investigation.

[55]  G. Burn.  Urinary excretion of the pressor amines in relation to phaeochromocytoma. , 1953, British medical journal.