论文信息 - Smooth endoplasmic reticulum aggregations in all retrieved oocytes causing recurrent multiple anomalies: case report.

Smooth endoplasmic reticulum aggregations in all retrieved oocytes causing recurrent multiple anomalies: case report.

OBJECTIVE To document the relationship between smooth endoplasmic reticulum (SER) aggregations and recurrent fetal anomalies. DESIGN Case report. SETTING Private IVF center. PATIENT(S) A 28-year-old woman with an 11-year history of primary infertility. INTERVENTION(S) Three consecutive cycles of intracytoplasmic sperm injection (ICSI) in the same patient. MAIN OUTCOME MEASURE(S) Clinical pregnancy, live birth, fetal anomaly. RESULT(S) In three consecutive ICSI cycles, a total of 59 MII oocytes were retreived in the same patient, all displaying SER aggregations. The fertilization rate per cycle was 80%, 50%, and 42%, respectively. A total of 12 embryos were transferred in three ICSI cycles, of which 11 were grade 1 embryos. Two of the three cycles ended up with clinical ongoing pregnancies but with multiple fetal anomalies. CONCLUSION(S) This is the first case reported with SER aggregations in all retrieved oocytes in three consecutive ICSI cycles. The repetetive multiple fetal anomalies possibly related to oocyte dysmorphism are of concern.

[1] S. Lindenberg,et al. Morphology of in-vitro matured oocytes: impact on fertility potential and embryo quality. , 2001, Human reproduction.

[2] S. Homa,et al. Fertilization and early embryology: The role of calcium in mammalian oocyte maturation and egg activation , 1993 .

[3] Thomas Ebner,et al. Is oocyte morphology prognostic of embryo developmental potential after ICSI? , 2006, Reproductive biomedicine online.

[4] R. Casper,et al. Tracking of oocyte dysmorphisms for ICSI patients may prove relevant to the outcome in subsequent patient cycles. , 2001, Human reproduction.

[5] J. Otsuki,et al. The relationship between pregnancy outcome and smooth endoplasmic reticulum clusters in MII human oocytes. , 2004, Human reproduction.

[6] J. van Blerkom,et al. Cytogenetic analysis of living human oocytes: cellular basis and developmental consequences of perturbations in chromosomal organization and complement. , 1988, Human Reproduction.

[7] Thomas Ebner,et al. Prognosis of oocytes showing aggregation of smooth endoplasmic reticulum. , 2008, Reproductive biomedicine online.

[8] J. Tesarik. 7c Use of immature germ cells for the treatment of male infertility , 1997 .

[9] J. van Blerkom,et al. Oocyte dysmorphism and aneuploidy in meiotically mature human oocytes after ovarian stimulation. , 1992, Human reproduction.