Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101.

[1]  C. Billard,et al.  Design of novel BH3 mimetics for the treatment of chronic lymphocytic leukemia , 2012, Leukemia.

[2]  A. Chanan-Khan,et al.  Downregulation of BCL2 by AT‐101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner , 2012, British journal of haematology.

[3]  Xia Guo,et al.  Pro-apoptotic protein BIM in apoptosis of glucocorticoid-sensitive and -resistant acute lymphoblastic leukemia CEM cells , 2011, Medical oncology.

[4]  F. Chew,et al.  BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia. , 2011, Experimental hematology.

[5]  Guan-Ming Li,et al.  Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells. , 2010, European journal of pharmacology.

[6]  H. Harada,et al.  GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy , 2010, Cell Death and Disease.

[7]  S. Edwards,et al.  Mcl‐1; the molecular regulation of protein function , 2010, FEBS letters.

[8]  B. Schäfer,et al.  Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. , 2010, The Journal of clinical investigation.

[9]  S. Armstrong,et al.  Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia. , 2010, Blood.

[10]  C. Reynolds,et al.  Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy , 2009, Clinical Cancer Research.

[11]  K. Pienta,et al.  -(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro. , 2008, Pharmacological research.

[12]  M. Keating,et al.  Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. , 2008, Blood.

[13]  K. Pienta,et al.  Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa , 2008, Molecular Cancer Therapeutics.

[14]  C. Felix,et al.  Abundant anti‐apoptotic BCL‐2 is a molecular target in leukaemias with t(4;11) translocation , 2008, British journal of haematology.

[15]  R. Kofler,et al.  The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia , 2008, Leukemia.

[16]  Wen-Qi Jiang,et al.  Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and chemotherapeutic agents in non-Hodgkin’s lymphoma cells , 2008, Cancer biology & therapy.

[17]  R. Pieters,et al.  A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial , 2007, The Lancet.

[18]  T. Golub,et al.  Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. , 2006, Cancer cell.

[19]  P. Dent,et al.  The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 through a Transcriptional Mechanism , 2006, Molecular Pharmacology.

[20]  M. Hung,et al.  Degradation of Mcl-1 by β-TrCP Mediates Glycogen Synthase Kinase 3-Induced Tumor Suppression and Chemosensitization , 2006, Molecular and Cellular Biology.

[21]  D. Green,et al.  Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. , 2006, Molecular cell.

[22]  A. Strasser,et al.  BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. , 2005, Blood.

[23]  E. Wickstrom,et al.  Inhibition of Glucocorticoid-induced Apoptosis by Targeting the Major Splice Variants of BIM mRNA with Small Interfering RNA and Short Hairpin RNA* , 2004, Journal of Biological Chemistry.

[24]  Cheng Cheng,et al.  Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. , 2004, The New England journal of medicine.

[25]  J. Miguel,et al.  Quantitative analysis of bcl-2 expression in normal and leukemic human B-cell differentiation , 2004, Leukemia.

[26]  M. D. Boer,et al.  Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemia. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[27]  Huiling He,et al.  Microarray Analysis Uncovers the Induction of the Proapoptotic BH3-only Protein Bim in Multiple Models of Glucocorticoid-induced Apoptosis* , 2003, Journal of Biological Chemistry.

[28]  Y. Bertrand,et al.  Role of BCL‐2 and cell cycle regulatory proteins for corticosensitivity assessment in childhood acute lymphoblastic leukaemia , 2000, British journal of haematology.

[29]  A. Borkhardt,et al.  Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia. , 1999, Blood.

[30]  R. Pieters,et al.  Prednisolone resistance in childhood acute lymphoblastic leukemia: vitro-vivo correlations and cross-resistance to other drugs. , 1998, Blood.

[31]  Z. Wang,et al.  DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III. , 1998, Molecular cell.

[32]  M. Greaves.  Infant leukaemia biology, aetiology and treatment. , 1996, Leukemia.

[33]  S. Grant,et al.  Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. , 1994, Cancer research.

[34]  V. Gandhi,et al.  AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. , 2009, Blood.

[35]  M. Konopleva,et al.  Bcl2 phosphorylation and active PKC α are associated with poor survival in AML , 2006, Leukemia.

[36]  B. Hajto,et al.  Induction of apoptosis and bcl-2 expression in acute lymphoblastic leukaemia and non-Hodgkin's lymphoma in children. , 2001, Haematologia.

[37]  W. May,et al.  Phosphorylation of Bcl2 and regulation of apoptosis , 2001, Leukemia.

[38]  R. Pieters,et al.  BCL-2 expression in childhood leukemia versus spontaneous apoptosis, drug induced apoptosis, and in vitro drug resistance. , 1999, Advances in experimental medicine and biology.