Stevia Derivative and its Potential Uses in Diabetic-Directed Foods. Review

Diabetes has been contextualized as pandemic, but market supplying their food does not seem to grow in parallel with the problem. There are many substances on the market that will be useful as ingredients to produce foods for diabetic consumers, focusing on the sweeteners, which can be used for food processing with low calories, and low glycemic index. Natural or synthetic sweeteners have received renewed attention with the toxicological acceptance and commercial development. However, many of them have little prospect of becoming commercial ingredients because, they do not meet some of the key criteria for commercial success. The stevia plant and its products have potential for commercial uses as sweetener or therapeutic. Beside the two known main molecules that are intense sweeteners that are occurring in stevia (stevioside and rebaudioside A), the plant contain other compounds of nutritional importance for therapeutic uses. The acceptable daily intake or ADI of 4 mg/kg bw/day to steviol glycosides have been regulated to glycosides of stevia. Moreover, there exists production of stevia worldwide, with established procedures for isolation and purification of its glycosides and one of them has been approved for food use. Then, a solid market of diabetes-oriented products must emerge, for satisfying demands from these consumers.

[1]  V. Sardesai,et al.  Natural and synthetic intense sweeteners , 1991 .

[2]  P. Shankar,et al.  Non-nutritive sweeteners: review and update. , 2013, Nutrition.

[3]  G. I. Kourtoglou Insulin therapy and exercise. , 2011, Diabetes research and clinical practice.

[4]  M. O’Mullane,et al.  Food Additives: Sweeteners , 2014 .

[5]  G. Mohamed,et al.  Natural anti-obesity agents , 2014 .

[6]  O. Yesil‐Celiktas,et al.  Supercritical CO2 extraction of glycosides from Stevia rebaudiana leaves: Identification and optimization , 2009 .

[7]  M. Mello Legal and policy approaches to the obesity epidemic. , 2012, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

[8]  G. Brahmachari,et al.  Stevioside and Related Compounds — Molecules of Pharmaceutical Promise: A Critical Overview , 2011 .

[9]  Helena Maria André Bolini,et al.  Sensory profile, acceptability, and their relationship for diabetic/reduced calorie chocolates , 2009 .

[10]  J. Schlienger Les édulcorants de masse ou de charge ont-ils leur place dans l’alimentation chez le patient diabétique ? , 2013 .

[11]  Gregory Dolin,et al.  8U.S. Food and Drug Administration , 2016 .

[12]  Min-Seon Kim,et al.  Decreased sucrose preference in patients with type 2 diabetes mellitus. , 2014, Diabetes research and clinical practice.

[13]  M. Puri,et al.  Downstream processing of stevioside and its potential applications. , 2011, Biotechnology advances.

[14]  K. Rosenman Benefits of saccharin: a review. , 1978, Environmental research.

[15]  R. Cadena,et al.  Sensory profile and physicochemical characteristics of mango nectar sweetened with high intensity sweeteners throughout storage time , 2013 .

[16]  B. Tomlinson,et al.  A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. , 2000, British journal of clinical pharmacology.

[17]  A. Morrill,et al.  The Obesity Epidemic in the United States , 2004, Journal of public health policy.

[18]  J. Buyse,et al.  Metabolism of Stevioside by Healthy Subjects , 2007, Experimental biology and medicine.

[19]  M. Kruhøffer,et al.  Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. , 2003, Metabolism: clinical and experimental.

[20]  S. Yadav,et al.  Steviol Glycosides from Stevia: Biosynthesis Pathway Review and their Application in Foods and Medicine , 2012, Critical reviews in food science and nutrition.

[21]  O. Lee,et al.  The antioxidant activity and the bioactive compound content of Stevia rebaudiana water extracts , 2011 .

[22]  J. Buyse,et al.  Evaluation of supplementary stevia (Stevia rebaudiana, bertoni) leaves and stevioside in broiler diets: effects on feed intake, nutrient metabolism, blood parameters and growth performance. , 2008, Journal of animal physiology and animal nutrition.

[23]  G. Dubois,et al.  Development of rebiana, a natural, non-caloric sweetener. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[24]  V. Kaul,et al.  An efficient microwave-assisted extraction process of stevioside and rebaudioside-A from Stevia rebaudiana (Bertoni). , 2009, Phytochemical analysis : PCA.

[25]  R. S. Lothrop Physicochemical and sensory quality of chiffon cake prepared with rebaudioside-A and erythritol as replacement for sucrose , 2007 .

[26]  E. Mosettig,et al.  The Absolute Configuration of Steviol and Isosteviol , 1963 .

[27]  G. Campus,et al.  An in vitro and in vivo Comparison of the Effect of Stevia rebaudiana Extracts on Different Caries-Related Variables: A Randomized Controlled Trial Pilot Study , 2013, Caries Research.

[28]  G. Rojo-Martínez,et al.  Evolución de la prevalencia de la diabetes tipo 2 en población adulta española , 2007 .

[29]  K. Keim,et al.  Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners. , 2012, Journal of the Academy of Nutrition and Dietetics.

[30]  I. Prakash,et al.  Stability of rebaudioside A under acidic conditions and its degradation products , 2012 .

[31]  Comisión de Candidaturas,et al.  ORGANIZACIÓN MUNDIAL DE LA SALUD , 1999 .

[32]  T. Oku,et al.  Laxative threshold of sugar alcohol erythritol in human subjects , 1996 .

[33]  Katherine M Flegal,et al.  Epidemiology of Obesity , 2014 .

[34]  J. Foreyt,et al.  The Role of Low-calorie Sweeteners in Diabetes. , 2013, European endocrinology.

[35]  J. Mckenney,et al.  The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[36]  H. King,et al.  Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections , 1998, Diabetes Care.

[37]  A. Kinghorn,et al.  Natural Products as Sweeteners and Sweetness Modifiers , 2010 .

[38]  A. Siddique,et al.  Chemical composition of essential oil by different extraction methods and fatty acid analysis of the leaves of Stevia Rebaudiana Bertoni , 2016 .

[39]  J. Impe,et al.  Application of tailor-made membranes in a multi-stage process for the purification of sweeteners from Stevia rebaudiana , 2011 .

[40]  Corby K. Martin,et al.  Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels , 2010, Appetite.

[41]  N. Brown,et al.  Rebaudioside A: two-generation reproductive toxicity study in rats. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[42]  S. Clark,et al.  Use of just-about-right scales and penalty analysis to determine appropriate concentrations of stevia sweeteners for vanilla yogurt. , 2014, Journal of dairy science.

[43]  G. Reaven,et al.  Metabolic effects of added dietary sucrose in individuals with noninsulin-dependent diabetes mellitus (NIDDM). , 1985, Metabolism: clinical and experimental.

[44]  R. Mehrotra STEVIOL GLYCOSIDES AND THEIR USE IN FOOD PROCESSING: A REVIEW , 2014 .

[45]  B. Caballero Sucrose | Dietary sucrose and disease , 2005 .

[46]  D. Brusick,et al.  Overview: the history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[47]  L. Sjöström,et al.  Role of Sweeteners in Food Flavor , 1955 .

[48]  M. Fantino Effets nutritionnels et métaboliques des édulcorants intenses , 2011 .

[49]  D. Parent‐Massin Édulcorants intenses : point d’actualité sur leur sécurité d’emploi et les dernières innovations , 2011 .

[50]  A. M. Viana,et al.  Changes in the levels of total soluble proteins and sugars during leaf ontogeny in Stevia rebaudiana Bert. , 1980 .

[51]  C. Boonkaewwan,et al.  Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. , 2006, Journal of agricultural and food chemistry.

[52]  M. Tapia,et al.  Main properties of steviol glycosides and their potential in the food industry: a review , 2014 .

[53]  A. Abou-Arab,et al.  Physico-chemical assessment of natural sweeteners steviosides produced from Stevia rebaudiana bertoni plant , 2009 .

[54]  Kevin O. Hwang,et al.  Feasibility of utilising an all-volunteer workforce as a disruptive innovation for the US obesity epidemic. , 2014, Obesity research & clinical practice.

[55]  I. Munro,et al.  Stevioside and related compounds: therapeutic benefits beyond sweetness. , 2009, Pharmacology & therapeutics.

[56]  J. Buyse,et al.  Metabolism of stevioside in pigs and intestinal absorption characteristics of stevioside, rebaudioside A and steviol. , 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[57]  G. Beauchamp,et al.  Early Flavor Learning and Its Impact on Later Feeding Behavior , 2009, Journal of pediatric gastroenterology and nutrition.

[58]  S. Karlović,et al.  Physical, bioactive and sensory quality parameters of reduced sugar chocolates formulated with natural sweeteners as sucrose alternatives. , 2015, Food chemistry.

[59]  J. Brandle,et al.  Steviol glycoside biosynthesis. , 2007, Phytochemistry.

[60]  H M A Bolini,et al.  Development of chocolate dairy dessert with addition of prebiotics and replacement of sucrose with different high-intensity sweeteners. , 2014, Journal of dairy science.

[61]  J. Fry Natural low-calorie sweeteners , 2012 .

[62]  P. Dworatzek,et al.  Food and dietary pattern-based recommendations: an emerging approach to clinical practice guidelines for nutrition therapy in diabetes. , 2013, Canadian journal of diabetes.

[63]  E. Pérez,et al.  Caracterización de cultivares de Stevia rebaudiana Bertoni de diferentes procedencias , 2014 .

[64]  Monzur Hossain,et al.  A review on natural sweetener plant - Stevia having medical and commercial importance , 2011 .

[65]  L. Monnier,et al.  Les édulcorants : effets métaboliques et sur la santé , 2010 .

[66]  Duolong Di,et al.  Preparative isolation and purification of steviol glycosides from Stevia rebaudiana Bertoni using high-speed counter-current chromatography , 2010 .

[67]  K. Hermansen,et al.  Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. , 2000, Metabolism: clinical and experimental.

[68]  K. Rother,et al.  Artificial sweetener use among children: epidemiology, recommendations, metabolic outcomes, and future directions. , 2011, Pediatric clinics of North America.

[69]  S. Wild,et al.  Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. , 2004, Diabetes care.

[70]  A. Vega‐Gálvez,et al.  Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects. , 2012, Food chemistry.

[71]  B. Popkin,et al.  Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. , 2009, The American journal of clinical nutrition.

[72]  G. Reaven,et al.  Deleterious metabolic effects of high-carbohydrate, sucrose-containing diets in patients with non-insulin-dependent diabetes mellitus. , 1987, The American journal of medicine.

[73]  F. Muanda,et al.  Study on chemical composition and biological activities of essential oil and extracts from Stevia rebaudiana Bertoni leaves , 2011 .

[74]  Y. Ravikumar,et al.  Simple extraction and membrane purification process in isolation of steviosides with improved organoleptic activity , 2012 .

[75]  J. Mckenney,et al.  Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitus. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[76]  P. Breslin,et al.  An Evolutionary Perspective on Food and Human Taste , 2013, Current Biology.

[77]  Jinwei Li,et al.  Ultrasonically assisted extraction of total carbohydrates from Stevia rebaudiana Bertoni and identification of extracts , 2010 .

[78]  L. Bell,et al.  Degradation kinetics of rebaudioside A in various buffer solutions , 2013 .

[79]  R. Boakes,et al.  Maltodextrin can produce similar metabolic and cognitive effects to those of sucrose in the rat ☆ , 2014, Appetite.

[80]  G. Dubois,et al.  Diterpenoid sweeteners. Synthesis and sensory evaluation of stevioside analogues with improved organoleptic properties. , 1985, Journal of medicinal chemistry.

[81]  J. Holst,et al.  Antihyperglycemic effects of stevioside in type 2 diabetic subjects. , 2004, Metabolism: clinical and experimental.

[82]  Francisco-José Santonja,et al.  Probabilistic stability analysis of social obesity epidemic by a delayed stochastic model , 2014 .