Enhanced Sensitivity of Gas Sensor Based on Poly(3-hexylthiophene) Thin-Film Transistors for Disease Diagnosis and Environment Monitoring

Electronic devices based on organic thin-film transistors (OTFT) have the potential to supply the demand for portable and low-cost gadgets, mainly as sensors for in situ disease diagnosis and environment monitoring. For that reason, poly(3-hexylthiophene) (P3HT) as the active layer in the widely-used bottom-gate/bottom-contact OTFT structure was deposited over highly-doped silicon substrates covered with thermally-grown oxide to detect vapor-phase compounds. A ten-fold organochloride and ammonia sensitivity compared to bare sensors corroborated the application of this semiconducting polymer in sensors. Furthermore, P3HT TFTs presented approximately three-order higher normalized sensitivity than any chemical sensor addressed herein. The results demonstrate that while TFTs respond linearly at the lowest concentration values herein, chemical sensors present such an operating regime mostly above 2000 ppm. Simultaneous alteration of charge carrier mobility and threshold voltage is responsible for pushing the detection limit down to units of ppm of ammonia, as well as tens of ppm of alcohol or ketones. Nevertheless, P3HT transistors and chemical sensors could compose an electronic nose operated at room temperature for a wide range concentration evaluation (1–10,000 ppm) of gaseous analytes. Targeted analytes include not only biomarkers for diseases, such as uremia, cirrhosis, lung cancer and diabetes, but also gases for environment monitoring in food, cosmetic and microelectronics industries.

[1]  A. Berg,et al.  Ammonia sensors and their applications - a review , 2005 .

[2]  W. M. Haynes CRC Handbook of Chemistry and Physics , 1990 .

[3]  Carmen Bartic,et al.  Organic thin-film transistors as transducers for (bio) analytical applications , 2005, Analytical and bioanalytical chemistry.

[4]  L. Laffel Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes , 1999, Diabetes/metabolism research and reviews.

[5]  Ki-Hyun Kim,et al.  A review of breath analysis for diagnosis of human health , 2012 .

[6]  S. M. Sze,et al.  Physics of semiconductor devices , 1969 .

[7]  A. L. Harmer,et al.  Environmental Monitoring , 2018, Nano-Tera.ch.

[8]  A proportionate cancer morbidity ratio study of workers exposed to chlorinated organic solvents in Taiwan. , 2003, Industrial health.

[9]  Göran Gustafsson,et al.  Determination of field-effect mobility of poly(3-hexylthiophene) upon exposure to NH3 gas , 1990 .

[10]  P. Blom,et al.  Local charge carrier mobility in disordered organic field-effect transistors , 2003 .

[11]  S. Thalhammer,et al.  Toward Cheap Disposable Sensing Devices for Biological Assays , 2010, IEEE Transactions on Nanotechnology.

[12]  E. Itoh,et al.  Interfacial charge phenomena at the semiconductor/gate insulator interface in organic field effect transistors , 2006 .

[13]  J. Grate,et al.  Solubility interactions and the design of chemically selective sorbent coatings for chemical sensors and arrays , 1991 .

[14]  Agnès Rivaton,et al.  The mechanism of photo- and thermooxidation of poly(3-hexylthiophene) (P3HT) reconsidered , 2009 .

[15]  Il Ki Han,et al.  The response characteristics of a gas sensor based on poly-3-hexylithiophene thin-film transistors , 2010 .

[16]  K. Hemminki,et al.  Organic solvents and cancer , 1997, Cancer Causes & Control.

[17]  M. Urien,et al.  Polymeric solar cells based on P3HT:PCBM: Role of the casting solvent , 2011 .

[18]  Leonardo G. Paterno,et al.  Performance of an electronic tongue during monitoring 2-methylisoborneol and geosmin in water samples , 2012 .

[19]  Russell Binions,et al.  Metal Oxide Semi-Conductor Gas Sensors in Environmental Monitoring , 2010, Sensors.

[20]  V. Mavrantzas,et al.  All-Atom Molecular Dynamics Simulation of Temperature Effects on the Structural, Thermodynamic, and Packing Properties of the Pure Amorphous and Pure Crystalline Phases of Regioregular P3HT , 2013 .

[21]  Lee E. Weiss,et al.  Inkjet printed chemical sensor array based on polythiophene conductive polymers , 2007 .

[22]  A. Arias,et al.  Materials and applications for large area electronics: solution-based approaches. , 2010, Chemical reviews.

[23]  R. C. Weast CRC Handbook of Chemistry and Physics , 1973 .

[24]  P. Chakrabarti,et al.  Poly-3-hexylthiophene based organic field-effect transistor: Detection of low concentration of ammonia , 2012 .

[25]  Marco Santonico,et al.  A sensor array based on mass and capacitance transducers for the detection of adulterated gasolines , 2009 .

[26]  D. Andrienko,et al.  Effect of Polymorphism, Regioregularity and Paracrystallinity on Charge Transport in Poly(3-hexylthiophene) [P3HT] Nanofibers , 2013 .

[27]  M F Rubner,et al.  Conductive polymer films as ultrasensitive chemical sensors for hydrazine and monomethylhydrazine vapor. , 1996, Analytical chemistry.

[28]  Vivek Subramanian,et al.  Printable polythiophene gas sensor array for low-cost electronic noses , 2006 .

[29]  Leonce J. Sevin,et al.  Field-effect transistors , 1966 .

[30]  P. Španěl,et al.  Quantitative analysis of ammonia on the breath of patients in end-stage renal failure. , 1997, Kidney international.

[31]  E. Reichmanis,et al.  Electrical contact properties between the accumulation layer and metal electrodes in ultrathin poly(3-hexylthiophene)(P3HT) field effect transistors. , 2011, ACS applied materials & interfaces.

[32]  Gebo Pan,et al.  Ammonia Chemiresistor Sensor Based on Poly(3-Hexylthiophene) Film Oxidized by Nitrosonium Hexafluorophosphate , 2012 .

[33]  R. Binions,et al.  13 – Metal oxide semiconductor gas sensors in environmental monitoring , 2013 .

[34]  J. Pawliszyn,et al.  Solid-phase microextraction for the analysis of human breath. , 1997, Analytical chemistry.

[35]  F. Krebs,et al.  A roll-to-roll process to flexible polymer solar cells: model studies, manufacture and operational stability studies , 2009 .

[36]  Osvaldo N. Oliveira,et al.  In situ thickness measurements of ultra-thin multilayer polymer films by atomic force microscopy , 1999 .

[37]  P. Zimmet,et al.  Diagnosis and classification of diabetes mellitus , 2002 .

[38]  Junbiao Peng,et al.  Poly(3-hexylthiophene) Thin-Film Transistors with Dual insulator Layers , 2007 .

[39]  Veit Wagner,et al.  Influence of the semiconductor thickness on the charge carrier mobility in P3HT organic field-effect transistors in top-gate architecture on flexible substrates , 2010 .

[40]  Jisun Im,et al.  A hybrid chemiresistive sensor system for the detection of organic vapors , 2011 .

[41]  L. Torsi,et al.  Effects of Annealing and Residual Solvents on Amorphous P3HT and PBTTT Films , 2014 .

[42]  A. Manolis,et al.  The diagnostic potential of breath analysis. , 1983, Clinical chemistry.

[43]  Pau-Chung Chen,et al.  Increased risk of cancer in the offspring of female electronics workers. , 2008, Reproductive toxicology.

[44]  P. O S I T I O N S T A T E M E N T,et al.  Diagnosis and Classification of Diabetes Mellitus , 2011, Diabetes Care.