Anti-phospholipase A2 receptor antibody and spontaneous remission in membranous nephropathy

Abstract Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in native kidney biopsies from adults. In 2009, antibodies to the M-type receptor of phospholipase A2 (anti-PLA2R) were identified in idiopathic MN patients, both within the kidney and in the circulation. The clinical course of idiopathic MN is variable and ranges from spontaneous remission to end-stage renal disease. Clinical variables such as proteinuria levels, patient sex, age and renal function at diagnosis have been associated with renal MN progression. In this editorial, we update the importance of anti-PLA2R levels as a prognostic marker in idiopathic MN at the diagnosis of the disease.

[1]  L. Quintana,et al.  Antiphospholipase 2 receptor antibody levels to predict complete spontaneous remission in primary membranous nephropathy , 2018, Clinical kidney journal.

[2]  J. Shang,et al.  The prognostic value of phospholipase A2 receptor autoantibodies on spontaneous remission for patients with idiopathic membranous nephropathy , 2018, Medicine.

[3]  W. Couser.  Primary Membranous Nephropathy. , 2017, Clinical journal of the American Society of Nephrology : CJASN.

[4]  K. Nath,et al.  A Proposal for a Serology-Based Approach to Membranous Nephropathy. , 2017, Journal of the American Society of Nephrology : JASN.

[5]  K. Dwyer,et al.  PLA2R and membranous nephropathy: A 3 year prospective Australian study , 2016, Nephrology.

[6]  L. Beck,et al.  Idiopathic Membranous Nephropathy: Diagnostic and Therapeutic Challenges , 2016, American Journal of Nephrology.

[7]  H. Debiec,et al.  Membranous nephropathy: A fairy tale for immunopathologists, nephrologists and patients. , 2015, Molecular immunology.

[8]  J. Klein,et al.  Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. , 2015, The New England journal of medicine.

[9]  E. Imai,et al.  Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy , 2014, Clinical and Experimental Nephrology.

[10]  W. Liu,et al.  The Diagnosis Accuracy of PLA2R-AB in the Diagnosis of Idiopathic Membranous Nephropathy: A Meta-Analysis , 2014, PloS one.

[11]  E. Messias,et al.  Determination of primary versus secondary membranous glomerulopathy utilizing phospholipase A2 receptor staining in renal biopsies , 2013, Modern Pathology.

[12]  S. Menon,et al.  Membranous nephropathy in children: clinical presentation and therapeutic approach , 2009, Pediatric Nephrology.

[13]  David M. Beck,et al.  M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. , 2009, The New England journal of medicine.