Localization of adipose tissue influence on obesity-dependent diseases. In obese people many abnormalities are observed connected with coagulation factors and fibrinolysis. We studied 47 peri- and postmenopausal female patients, who were operated on for benign changes within the pelvis minor. The patients were divided according to BMI (group I--BMI < 25 kg/m2, group II--BMI > 29 kg/m2). In obese women lower SHBG concentration, higher insulin and glucose fasting blood levels, higher LDL, higher total fatty tissue content, higher fibrinogen level and elevated PAI-1 activity were found. A positive correlation between area under insulin curve and PAI-1 activity and a negative correlation between fasting insulin levels and tPA were also observed. Based on the studies performed it can be said that: 1. Fatty tissue content in postmenopausal women exerts an influence on PAI-1 activity. 2. Obesity influences coagulation and fibrinolysis system in peri- and postmenopausal women. 3. Carbohydrate metabolism disturbances have influence on PAI-1 activity in peri- and postmenopausal women.