The effects of B vitamins, liver, and yeast on promin toxicity in the rat.

Toxic effects resulting from the administration of massive doses of promin were largely counteracted in rats by the administration of desiccated whole liver. The protective factor was distinct from any of the known vitamins and was not present in the casein or salt mixture employed. The suggestion is mad ethat many of the toxic effects observed in animals fed massive doses of Certain drugs are in reality due to a deficiency of an unknown nutrient(s) resulting from an increased requirement following drug administration. Desiccated whole liver is a rich source of this unknown factor(s).