Reconsolidation of episodic memories: a subtle reminder triggers integration of new information.

Recent demonstrations of "reconsolidation" suggest that memories can be modified when they are reactivated. Reconsolidation has been observed in human procedural memory and in implicit memory in infants. This study asks whether episodic memory undergoes reconsolidation. College students learned a list of objects on Day 1. On Day 2, they received a reminder or not, and then learned a second list. Memory for List 1 was tested immediately on Day 2 (Experiment 2) or on Day 3 (Experiment 1). Although the reminder did not moderate the number of items recalled from List 1 on either day, subjects who received a reminder incorrectly intermixed items from the second list when recalling List 1 on Day 3. Experiment 2 showed that this effect does not occur immediately and thus is time-dependent. The reminder did not affect memory for List 2 on Day 3 (Experiment 3), demonstrating that modification occurred only for the original memory (List 1). The study demonstrates the crucial role of reminders for the modification of episodic memory, that reconsolidation of episodic memory is time-dependent, and, in contrast to previous reconsolidation findings, that reconsolidation is also a constructive process, one that supports the incorporation of new information in memory.

[1]  G. Müller,et al.  Experimentelle Beiträge zur Lehre vom Gedächtniss , 1900 .

[2]  Perla b. Ephrussi.  Experimentelle Beiträge zur Lehre vom Gedächtnis , 1904 .

[3]  F. Bartlett,et al.  Remembering: A Study in Experimental and Social Psychology , 1932 .

[4]  B. Underwood,et al.  Fate of first-list associations in transfer theory. , 1959, Journal of experimental psychology.

[5]  D. J. Lewis,et al.  Recovery of Memory following Amnesia , 1968, Nature.

[6]  D. J. Lewis,et al.  Retrograde Amnesia Produced by Electroconvulsive Shock after Reactivation of a Consolidated Memory Trace , 1968, Science.

[7]  B. Underwood,et al.  Critical issues in interference theory , 1973, Memory & cognition.

[8]  Elizabeth F Loftus,et al.  Leading questions and the eyewitness report , 1975, Cognitive Psychology.

[9]  E. Tulving.  Précis of Elements of episodic memory , 1984, Behavioral and Brain Sciences.

[10]  M. McCloskey,et al.  Misleading postevent information and memory for events: arguments and evidence against memory impairment hypotheses. , 1985, Journal of experimental psychology. General.

[11]  C. Brainerd,et al.  Development of children's long-term retention , 1989 .

[12]  D. G. Payne,et al.  Role of environmental context in eyewitness memory. , 1991, The American journal of psychology.

[13]  Marcia K. Johnson,et al.  Source monitoring. , 1993, Psychological bulletin.

[14]  M. Wheeler,et al.  Improvement in recall over time without repeated testing: Spontaneous recovery revisited. , 1995 .

[15]  J. Przybysławski,et al.  Reconsolidation of memory after its reactivation , 1997, Behavioural Brain Research.

[16]  L. Nadel,et al.  Memory consolidation, retrograde amnesia and the hippocampal complex , 1997, Current Opinion in Neurobiology.

[17]  L. Nadel,et al.  Consolidation and the hippocampal complex revisited: in defense of the multiple-trace model , 1998, Current Opinion in Neurobiology.

[18]  K. Nader,et al.  Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval , 2000, Nature.

[19]  S. Sara.  Retrieval and reconsolidation: toward a neurobiology of remembering. , 2000, Learning & memory.

[20]  J. D. McGaugh.  Memory--a century of consolidation. , 2000, Science.

[21]  K. Mitchell,et al.  Contextual overlap and eyewitness suggestibility , 2001, Memory & cognition.

[22]  R. Stickgold,et al.  Dissociable stages of human memory consolidation and reconsolidation , 2003, Nature.

[23]  Karim Nader,et al.  Memory traces unbound , 2003, Trends in Neurosciences.

[24]  Y. Dudai,et al.  Rites of Passage of the Engram Reconsolidation and the Lingering Consolidation Hypothesis , 2004, Neuron.

[25]  B. P. Allen,et al.  Eyewitness suggestibility and source similarity: Intrusions of details from one event into memory reports of another event ☆ , 2004 .

[26]  Cristina M. Alberini,et al.  Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? , 2005, Trends in Neurosciences.

[27]  L. Galluccio,et al.  Updating reactivated memories in infancy: I. Passive- and active-exposure effects. , 2005, Developmental psychobiology.

[28]  K. Nader,et al.  Response to Alberini: right answer, wrong question , 2005, Trends in Neurosciences.

[29]  D. Delprato.  Retroactive interference as a function of degree of interpolated study without overt retrieval practice , 2005, Psychonomic bulletin & review.

[30]  C. Rovee-Collier,et al.  Updating reactivated memories in infancy: II. Time passage and repetition effects. , 2005, Developmental psychobiology.

[31]  B. Balleine,et al.  Consolidation and Reconsolidation of Incentive Learning in the Amygdala , 2005, The Journal of Neuroscience.

[32]  E. Loftus.  Planting misinformation in the human mind: a 30-year investigation of the malleability of memory. , 2005, Learning & memory.

[33]  G. Winocur,et al.  Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory , 2005, Journal of anatomy.