Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential

[1]  L. D. Barnes,et al.  Phosphorylation of the human Fhit tumor suppressor on tyrosine 114 in Escherichia coli and unexpected steady state kinetics of the phosphorylated forms. , 2005, Biochemistry.

[2]  Dimitrios Iliopoulos,et al.  Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer , 2005, Oncogene.

[3]  K. Huebner,et al.  Involvement of the Fhit gene in the ionizing radiation‐activated ATR/CHK1 pathway , 2005, Journal of cellular physiology.

[4]  M. Kasuga,et al.  High Expression of PRL-3 Promotes Cancer Cell Motility and Liver Metastasis in Human Colorectal Cancer , 2004, Clinical Cancer Research.

[5]  C. Croce,et al.  Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant , 2004, British Journal of Cancer.

[6]  C. Croce,et al.  Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice , 2004, British Journal of Cancer.

[7]  J. Minna,et al.  Synergistic Tumor Suppression by Coexpression of FHIT and p53 Coincides with FHIT-Mediated MDM2 Inactivation and p53 Stabilization in Human Non-Small Cell Lung Cancer Cells , 2004, Cancer Research.

[8]  L. D. Barnes,et al.  Fhit is a physiological target of the protein kinase Src. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[9]  D. Coppola,et al.  Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis , 2004, Oncogene.

[10]  M. Fornaro,et al.  Fibronectin Protects Prostate Cancer Cells from Tumor Necrosis Factor-α-induced Apoptosis via the AKT/Survivin Pathway* , 2003, Journal of Biological Chemistry.

[11]  Yiling Lu,et al.  Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT Cascades* , 2003, Journal of Biological Chemistry.

[12]  C. Croce,et al.  Cancer and the FRA3B/FHIT fragile locus: it's a HIT , 2003, British Journal of Cancer.

[13]  C. Croce,et al.  Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Masaharu Akiyama,et al.  Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications , 2002, Oncogene.

[15]  C. Sawyers,et al.  The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.

[16]  C. Croce,et al.  Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[17]  C. Croce,et al.  The tumor spectrum in FHIT-deficient mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[18]  Christine Brun,et al.  In silico prediction of protein-protein interactions in human macrophages , 2001, BMC Research Notes.

[19]  M. Paterson,et al.  Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9. , 2000, The Biochemical journal.

[20]  R. Kalb,et al.  Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway* , 2000, The Journal of Biological Chemistry.

[21]  C. Croce,et al.  Role of FHIT in Human Cancer , 1999 .

[22]  Fengzhi Li,et al.  Control of apoptosis and mitotic spindle checkpoint by survivin , 1998, Nature.

[23]  L. D. Barnes,et al.  Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[24]  L. D. Barnes,et al.  Replacement of Fhit in cancer cells suppresses tumorigenicity. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[25]  L. D. Barnes,et al.  Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein. , 1997, Protein engineering.

[26]  D. Altieri,et al.  A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma , 1997, Nature Medicine.

[27]  J S Lee,et al.  Clonal genetic alterations in the lungs of current and former smokers. , 1997, Journal of the National Cancer Institute.

[28]  L. D. Barnes,et al.  Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase. , 1996, Biochemistry.

[29]  C. Croce,et al.  The FHIT Gene at 3p14.2 Is Abnormal in Lung Cancer , 1996, Cell.

[30]  C. Croce,et al.  The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers , 1996, Cell.

[31]  D. Altieri.  Validating survivin as a cancer therapeutic target , 2003, Nature Reviews Cancer.

[32]  L. D. Barnes,et al.  The role of the FHIT/FRA3B locus in cancer. , 1998, Annual review of genetics.