Cell cycle arrest and p53 prevent ON-target megabase-scale rearrangements induced by CRISPR-Cas9
暂无分享,去创建一个
D. Cappellen | G. Cullot | J. Boutin | F. Prat | P. Pennamen | J. Blouin | E. Richard | S. Dabernat | F. Moreau-Gaudry | A. Bedel | J. Merlio | J. Bouron | S. Amintas | I. Moranvillier | J. Rosier | V. Guyonnet-Duperat | E. Laharanne | I. Lamrissi | S. Fayet | C. Thibault
[1] A. Madi,et al. Frequent Aneuploidy in Primary Human T Cells after CRISPR-Cas9 cleavage , 2022, Nature biotechnology.
[2] K. Rajewsky,et al. Precise CRISPR-Cas–mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells , 2022, Science advances.
[3] D. Cappellen,et al. ON-target Adverse Events of CRISPR-Cas9 Nuclease: More Chaotic than Expected. , 2022, The CRISPR journal.
[4] R. Jaenisch,et al. Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing , 2021, Nature Communications.
[5] D. Cappellen,et al. CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells , 2021, Nature Communications.
[6] N. Maizels,et al. POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks , 2020, Proceedings of the National Academy of Sciences.
[7] A. Bradley,et al. Cas9-induced large deletions and small indels are controlled in a convergent fashion , 2020, bioRxiv.
[8] Cheng-Zhong Zhang,et al. Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing , 2020, Nature Genetics.
[9] David R. Liu,et al. Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors , 2020, Nature Biotechnology.
[10] K. Niakan,et al. Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos , 2020, Proceedings of the National Academy of Sciences.
[11] M. Dichgans,et al. Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing. , 2020, Cell reports.
[12] A. Levine. p53: 800 million years of evolution and 40 years of discovery , 2020, Nature Reviews Cancer.
[13] Oana M. Enache,et al. Cas9 activates the p53 pathway and selects for p53-inactivating mutations , 2020, Nature Genetics.
[14] Ian Tomlinson,et al. CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods , 2019, The CRISPR journal.
[15] M. Behlke,et al. Evaluation and Reduction of CRISPR Off-Target Cleavage Events , 2019, Nucleic acid therapeutics.
[16] Ivan Merelli,et al. Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response , 2019, Cell stem cell.
[17] G. Cullot,et al. CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations , 2019, Nature Communications.
[18] A. Rezza,et al. Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in , 2019, Scientific Reports.
[19] H. Nakauchi,et al. Efficient scarless genome editing in human pluripotent stem cells , 2018, Nature Methods.
[20] David R. Liu,et al. Base editing: precision chemistry on the genome and transcriptome of living cells , 2018, Nature Reviews Genetics.
[21] C. Don,et al. Erratum: Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates , 2018, Nature Biotechnology.
[22] James N. Hughes,et al. Large deletions induced by Cas9 cleavage , 2018, Nature.
[23] A. Malkova,et al. Break-Induced Replication: The Where, The Why, and The How. , 2018, Trends in genetics : TIG.
[24] Gregory McAllister,et al. p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells , 2018, Nature Medicine.
[25] J. Taipale,et al. CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response , 2018, Nature Medicine.
[26] A. Holland,et al. The impact of mitotic errors on cell proliferation and tumorigenesis , 2018, Genes & development.
[27] Yixue Li,et al. CRISPR/Cas9-mediated targeted chromosome elimination , 2017, Genome Biology.
[28] Lothar Hennighausen,et al. CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome , 2017, Nature Communications.
[29] James E Haber,et al. The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair. , 2016, DNA repair.
[30] Marcus Schmidt. Palbociclib - from Bench to Bedside and Beyond , 2016, Breast Care.
[31] Peter J. Campbell,et al. Chromothripsis and Kataegis Induced by Telomere Crisis , 2015, Cell.
[32] Hisashi Tanaka,et al. Replication fork integrity and intra-S phase checkpoint suppress gene amplification , 2015, Nucleic acids research.
[33] J. Doudna,et al. The new frontier of genome engineering with CRISPR-Cas9 , 2014, Science.
[34] L. Shaffer,et al. Large Inverted Duplications in the Human Genome Form via a Fold-Back Mechanism , 2014, PLoS genetics.
[35] Le Cong,et al. Multiplex Genome Engineering Using CRISPR/Cas Systems , 2013, Science.
[36] J. Murnane,et al. Telomere dysfunction and chromosome instability. , 2012, Mutation research.
[37] S. Warren,et al. Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants. , 2009, American journal of human genetics.
[38] Jiri Bartek,et al. An Oncogene-Induced DNA Damage Model for Cancer Development , 2008, Science.
[39] Karen H. Vousden,et al. p53 in health and disease , 2007, Nature Reviews Molecular Cell Biology.
[40] Hongmao Sun,et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[41] Yong Liao,et al. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation , 2001, Nature Cell Biology.
[42] M. Hung,et al. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells , 2001, Nature Cell Biology.
[43] P. Rouet,et al. Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[44] V. Rotter,et al. p53-dependent cell cycle control: response to genotoxic stress. , 1998, Seminars in cancer biology.