Comparison of the Genant-modified Sharp and van der Heijde-modified Sharp scoring methods for radiographic assessment in rheumatoid arthritis

Objectives: To compare the Genant-modified Sharp and van der Heijde-modified Sharp composite scoring methods for evaluating radiographs of the hands, wrists and feet in patients with rheumatoid arthritis. Materials & methods: Standardized radiographs of the hands, wrists and feet of 28 patients with established rheumatoid arthritis taken 1 year apart were scored independently with each of the two methods by two radiologists blinded to each other’s scores. One of the radiologists also re-read each case with each method to determine intrareader agreement. The smallest detectable change (SDC), normalized to the range of scores observed with each method, and the intra- and inter-reader reproducibilities expressed as intraclass correlation coefficients, were determined for each method. Results: The Genant–Sharp scores and van der Heijde–Sharp scores correlated strongly with each other (r2 ranged from 0.95 to 0.99) and demonstrated high intra- and inter-reader agreement (intraclass correlation coefficients rang...

[1]  S. van der Linden,et al.  Deciding on progression of joint damage in paired films of individual patients: smallest detectable difference or change , 2004, Annals of the rheumatic diseases.

[2]  R N Maini,et al.  Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study. , 2005, Arthritis and rheumatism.

[3]  H K Genant,et al.  Assessment of rheumatoid arthritis using a modified scoring method on digitized and original radiographs. , 1998, Arthritis and rheumatism.

[4]  D. Heijde,et al.  EFFECTS OF HYDROXYCHLOROQUINE AND SULPHASALAZINE ON PROGRESSION OF JOINT DAMAGE IN RHEUMATOID ARTHRITIS , 1989, The Lancet.

[5]  J. Moreland,et al.  Methods of scoring the progression of radiologic changes in rheumatoid arthritis. Correlation of radiologic, clinical and laboratory abnormalities. , 1971, Arthritis and rheumatism.

[6]  H. Genant,et al.  Abatacept inhibits progression of structural damage in rheumatoid arthritis: results from the long-term extension of the AIM trial , 2007, Annals of the rheumatic diseases.

[7]  F. Breedveld,et al.  The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. , 2006, Arthritis and rheumatism.

[8]  Maarten Boers,et al.  Variability of precision in scoring radiographic abnormalities in rheumatoid arthritis by experienced readers. , 2004, The Journal of rheumatology.

[9]  D. M. van der Heijde,et al.  Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial. , 2006, Arthritis and rheumatism.

[10]  H. Genant.  Methods of assessing radiographic change in rheumatoid arthritis. , 1983, The American journal of medicine.

[11]  H. Cox,et al.  Letter: Moorgate tube disaster: disputed alcohol findings. , 1975, Lancet.

[12]  H. Genant,et al.  Effects of Abatacept in Patients with Methotrexate-Resistant Active Rheumatoid Arthritis , 2006, Annals of Internal Medicine.

[13]  P. Shekelle,et al.  How to read radiographs according to the Sharp/van der Heijde method. , 1999 .

[14]  M. Boers.  Abatacept in Rheumatoid Arthritis: A New Branch on the Biologics Tree , 2006, Annals of Internal Medicine.

[15]  V. Strand,et al.  Radiographic data from recent randomized controlled trials in rheumatoid arthritis: what have we learned? , 2003, Arthritis and rheumatism.