Patterns of linkage disequilibrium in the human genome

[1]  G. McVean,et al.  Estimating recombination rates from population-genetic data , 2003, Nature Reviews Genetics.

[2]  P. Oefner,et al.  The extent of linkage disequilibrium in Arabidopsis thaliana , 2002, Nature Genetics.

[3]  Kevin R. Thornton,et al.  Nucleotide Variation Along the Drosophila melanogaster Fourth Chromosome , 2002, Science.

[4]  Andrew G Clark,et al.  Linkage disequilibrium and the mapping of complex human traits. , 2002, Trends in genetics : TIG.

[5]  L. Jorde,et al.  Nucleotide diversity and haplotype structure of the human angiotensinogen gene in two populations. , 2002, American journal of human genetics.

[6]  A. Syvänen Accessing genetic variation: genotyping single nucleotide polymorphisms , 2001, Nature Reviews Genetics.

[7]  S. Liu-Cordero,et al.  The discovery of single-nucleotide polymorphisms--and inferences about human demographic history. , 2001, American journal of human genetics.

[8]  S. P. Fodor,et al.  Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21 , 2001, Science.

[9]  S. Schaeffer,et al.  Protein variation in Adh and Adh-related in Drosophila pseudoobscura. Linkage disequilibrium between single nucleotide polymorphisms and protein alleles. , 2001, Genetics.

[10]  Frank Dudbridge,et al.  Haplotype tagging for the identification of common disease genes , 2001, Nature Genetics.

[11]  D. Goldstein Islands of linkage disequilibrium , 2001, Nature Genetics.

[12]  Sinead B. O'Leary,et al.  Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease , 2001, Nature Genetics.

[13]  J. Wall,et al.  Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels. , 2001, American journal of human genetics.

[14]  A. Jeffreys,et al.  Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex , 2001, Nature Genetics.

[15]  D. Hartl,et al.  Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans. , 2001, Genetics.

[16]  M. Daly,et al.  High-resolution haplotype structure in the human genome , 2001, Nature Genetics.

[17]  M. Nachman,et al.  Single nucleotide polymorphisms and recombination rate in humans. , 2001, Trends in genetics : TIG.

[18]  L Kruglyak,et al.  Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. , 2001, American journal of human genetics.

[19]  E. Lander,et al.  On the allelic spectrum of human disease. , 2001, Trends in genetics : TIG.

[20]  A. Clark,et al.  Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. , 2001, American journal of human genetics.

[21]  J. Stephens,et al.  Haplotype Variation and Linkage Disequilibrium in 313 Human Genes , 2001, Science.

[22]  J. Pritchard Are rare variants responsible for susceptibility to complex diseases? , 2001, American journal of human genetics.

[23]  J. Pritchard,et al.  Linkage disequilibrium in humans: models and data. , 2001, American journal of human genetics.

[24]  A. Grosovsky,et al.  Interchromosomal gene conversion at an endogenous human cell locus. , 2001, Genetics.

[25]  Pardis C Sabeti,et al.  Linkage disequilibrium in the human genome , 2001, Nature.

[26]  W. Eanes,et al.  Clinal variation for amino acid polymorphisms at the Pgm locus in Drosophila melanogaster. , 2001, Genetics.

[27]  D. Nickerson,et al.  Variation is the spice of life , 2001, Nature Genetics.

[28]  M. Daly,et al.  A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms , 2001, Nature.

[29]  J. Wall,et al.  Why is there so little intragenic linkage disequilibrium in humans? , 2001, Genetical research.

[30]  K. Kidd,et al.  Worldwide genetic analysis of the CFTR region. , 2001, American journal of human genetics.

[31]  E. Boerwinkle,et al.  Population structure in admixed populations: effect of admixture dynamics on the pattern of linkage disequilibrium. , 2001, American journal of human genetics.

[32]  L R Cardon,et al.  Extent and distribution of linkage disequilibrium in three genomic regions. , 2001, American journal of human genetics.

[33]  D. Nelson,et al.  Haplotypes at ATM identify coding-sequence variation and indicate a region of extensive linkage disequilibrium. , 2000, American journal of human genetics.

[34]  E Lai,et al.  The extent of linkage disequilibrium in four populations with distinct demographic histories. , 2000, American journal of human genetics.

[35]  J. Braverman,et al.  Linkage disequilibria and the site frequency spectra in the su(s) and su(w(a)) regions of the Drosophila melanogaster X chromosome. , 2000, Genetics.

[36]  Jon A Yamato,et al.  Maximum likelihood estimation of recombination rates from population data. , 2000, Genetics.

[37]  E. Boerwinkle,et al.  Cladistic structure within the human Lipoprotein lipase gene and its implications for phenotypic association studies. , 2000, Genetics.

[38]  M. Nachman,et al.  Microsatellite variation and recombination rate in the human genome. , 2000, Genetics.

[39]  K. Weiss,et al.  How many diseases does it take to map a gene with SNPs? , 2000, Nature Genetics.

[40]  L. Jorde,et al.  Linkage disequilibrium and the search for complex disease genes. , 2000, Genome research.

[41]  D. Goldstein,et al.  Consistent long-range linkage disequilibrium generated by admixture in a Bantu-Semitic hybrid population. , 2000, American journal of human genetics.

[42]  P. Andolfatto,et al.  A genome-wide departure from the standard neutral model in natural populations of Drosophila. , 2000, Genetics.

[43]  E. Benedikz,et al.  Genetic homogeneity of Icelanders: fact or fiction? , 2000, Nature Genetics.

[44]  J. Gilbert,et al.  SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. , 2000, American journal of human genetics.

[45]  John A. Todd,et al.  The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes , 2000, Nature Genetics.

[46]  Pui-Yan Kwok,et al.  Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28 , 2000, Nature Genetics.

[47]  Jonathan Scott Friedlaender,et al.  Haplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global representation of populations. , 2000, American journal of human genetics.

[48]  G. Abecasis,et al.  Single nucleotide polymorphism and linkage disequilibrium within the TCR α/δ locus , 2000 .

[49]  R. Nielsen Estimation of population parameters and recombination rates from single nucleotide polymorphisms. , 2000, Genetics.

[50]  J. Witte,et al.  Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations. , 2000, American journal of human genetics.

[51]  J. Wall,et al.  A comparison of estimators of the population recombination rate. , 2000, Molecular biology and evolution.

[52]  N E Morton,et al.  Genetic epidemiology of single-nucleotide polymorphisms. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[53]  J. Weber,et al.  Long homozygous chromosomal segments in reference families from the centre d'Etude du polymorphisme humain. , 1999, American journal of human genetics.

[54]  M. Carrington,et al.  A scan for linkage disequilibrium across the human genome. , 1999, Genetics.

[55]  A. Long,et al.  The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits. , 1999, Genome research.

[56]  N. Shen,et al.  Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis , 1999, Nature Genetics.

[57]  L. Kruglyak Prospects for whole-genome linkage disequilibrium mapping of common disease genes , 1999, Nature Genetics.

[58]  M. Rieder,et al.  Sequence variation in the human angiotensin converting enzyme , 1999, Nature Genetics.

[59]  N. Morton,et al.  Allelic association between marker loci. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[60]  E. Lander,et al.  Characterization of single-nucleotide polymorphisms in coding regions of human genes , 1999, Nature Genetics.

[61]  E. Boerwinkle,et al.  Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. , 1998, American journal of human genetics.

[62]  J. Terwilliger,et al.  Mapping Genes through the Use of Linkage Disequilibrium Generated by Genetic Drift: ‘Drift Mapping’ in Small Populations with No Demographic Expansion , 1998, Human Heredity.

[63]  S. Pääbo,et al.  Demographic history and linkage disequilibrium in human populations , 1997, Nature Genetics.

[64]  Francis S. Collins,et al.  Variations on a Theme: Cataloging Human DNA Sequence Variation , 1997, Science.

[65]  N Risch,et al.  The Future of Genetic Studies of Complex Human Diseases , 1996, Science.

[66]  N. Risch,et al.  A comparison of linkage disequilibrium measures for fine-scale mapping. , 1995, Genomics.

[67]  J. Kere,et al.  Fine mapping of the congenital chloride diarrhea gene by linkage disequilibrium. , 1995, American journal of human genetics.

[68]  N. Freimer,et al.  The distribution of linkage disequilibrium over anonymous genome regions. , 1995, Human molecular genetics.

[69]  L Kruglyak,et al.  High-resolution genetic mapping of complex traits. , 1995, American journal of human genetics.

[70]  R. Cann The history and geography of human genes , 1995, The Journal of Asian Studies.

[71]  E. Heyer,et al.  Variability of the genetic contribution of Quebec population founders associated to some deleterious genes. , 1995, American journal of human genetics.

[72]  Francis S. Collins,et al.  Positional cloning moves from perditional to traditional , 1995, Nature Genetics.

[73]  L. Jorde Linkage disequilibrium as a gene-mapping tool. , 1995, American journal of human genetics.

[74]  J. Stephens,et al.  Mapping by admixture linkage disequilibrium in human populations: limits and guidelines. , 1994, American journal of human genetics.

[75]  M. Boehnke,et al.  Limits of resolution of genetic linkage studies: implications for the positional cloning of human disease genes. , 1994, American journal of human genetics.

[76]  W S Watkins,et al.  Linkage disequilibrium patterns vary with chromosomal location: a case study from the von Willebrand factor region. , 1994, American journal of human genetics.

[77]  W S Watkins,et al.  Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region. , 1994, American journal of human genetics.

[78]  C. Aquadro,et al.  Evolutionary inferences from DNA variation at the 6-phosphogluconate dehydrogenase locus in natural populations of drosophila: selection and geographic differentiation. , 1994, Genetics.

[79]  P. O'Connell,et al.  Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mapping. , 1993, American journal of human genetics.

[80]  S. Schaeffer,et al.  Estimates of linkage disequilibrium and the recombination parameter determined from segregating nucleotide sites in the alcohol dehydrogenase region of Drosophila pseudoobscura. , 1993, Genetics.

[81]  B. Charlesworth,et al.  The effect of deleterious mutations on neutral molecular variation. , 1993, Genetics.

[82]  C. Zapata,et al.  On the detection of nonrandom associations between DNA polymorphisms in natural populations of Drosophila. , 1993, Molecular biology and evolution.

[83]  Eric Lander,et al.  Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland , 1992, Nature Genetics.

[84]  C. Aquadro,et al.  Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogaster , 1992, Nature.

[85]  L. Tsui,et al.  Identification of the cystic fibrosis gene: genetic analysis. , 1989, Science.

[86]  K. Weiss,et al.  Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[87]  R. Hudson Properties of a neutral allele model with intragenic recombination. , 1983, Theoretical population biology.

[88]  R. Lewontin The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. , 1964, Genetics.

[89]  G. Cannon The effects of natural selection on linkage disequilibrium and relative fitness in experimental populations of Drosophila melanogaster. , 1963, Genetics.

[90]  Howard C. Berg,et al.  Genetic analysis , 1957, Nature Biotechnology.