Low density lipoprotein cholesterol and coronary microvascular dysfunction in hypercholesterolemia.

[1]  R. Cohen,et al.  Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. , 1990, The Journal of clinical investigation.

[2]  R. Berne,et al.  Endothelium-dependent and -independent relaxations to adenosine in guinea pig aorta. , 1990, The American journal of physiology.

[3]  J L Witztum,et al.  Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. , 1989, The New England journal of medicine.

[4]  D. Harrison,et al.  Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production. , 1995, Circulation.

[5]  K. Kugiyama,et al.  LPC in oxidized LDL elicits vasocontraction and inhibits endothelium- dependent relaxation. , 1994, The American journal of physiology.

[6]  K. Pritchard,et al.  Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. , 1995, Circulation research.

[7]  P. Kaufmann,et al.  Normalization of abnormal coronary vasomotion by calcium antagonists in patients with hypertension. , 1996, Circulation.

[8]  M. Phelps,et al.  Effect of short-term cardiovascular conditioning and low-fat diet on myocardial blood flow and flow reserve. , 1995, Circulation.

[9]  R D Fish,et al.  Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy. , 1990, Circulation.

[10]  E. Bassenge,et al.  Coronary vasodilation to acetylcholine, adenosine and bradykinin in dogs: effects of inhibition of NO-synthesis and captopril. , 1993, European heart journal.

[11]  A. Dart,et al.  Lipids and the endothelium. , 1999, Cardiovascular research.

[12]  M. Marcus,et al.  Heterogeneous Microvascular Coronary α‐Adrenergic Vasoconstriction , 1989 .

[13]  H. Drexler,et al.  Endothelial Dysfunction of the Coronary Microvasculature Is Associated With Impaired Coronary Blood Flow Regulation in Patients With Early Atherosclerosis , 1991, Circulation.

[14]  J. Keaney,et al.  Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation. , 1995, The Journal of clinical investigation.

[15]  M. Gilardi,et al.  Physical performance of the latest generation of commercial positron scanner , 1988 .

[16]  A. Maseri,et al.  Intracoronary endothelin induces myocardial ischemia by small vessel constriction in the dog. , 1989, The American journal of cardiology.

[17]  K. Kugiyama,et al.  Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins , 1990, Nature.

[18]  R. Kerwin,et al.  CORONARY ARTERY INFUSION OF NEUROPEPTIDE Y IN PATIENTS WITH ANGINA PECTORIS , 1987, The Lancet.

[19]  Ames,et al.  PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA , 2000 .

[20]  R. Kavey,et al.  Exaggerated blood pressure response to exercise in children with increased low-density lipoprotein cholesterol. , 1997, American heart journal.

[21]  T J Spinks,et al.  Generation of myocardial factor images directly from the dynamic oxygen-15-water scan without use of an oxygen-15-carbon monoxide blood-pool scan. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[22]  O Muzik,et al.  Early Detection of Abnormal Coronary Flow Reserve in Asymptomatic Men at High Risk for Coronary Artery Disease Using Positron Emission Tomography , 1994, Circulation.

[23]  D. Harrison,et al.  Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. , 1991, Circulation research.

[24]  M. Omata,et al.  Reduced coronary flow reserve in familial hypercholesterolemia. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[25]  M. Cerqueira,et al.  Safety profile of adenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry. , 1994, Journal of the American College of Cardiology.

[26]  A. Zeiher,et al.  Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function. , 1995, Circulation.

[27]  H. Drexler,et al.  Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium. , 1989, Journal of the American College of Cardiology.

[28]  T. Imaizumi,et al.  Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans. , 1997, Circulation.

[29]  T. Lüscher,et al.  Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide. , 1991, Circulation.

[30]  M. Bell,et al.  Endothelin in coronary endothelial dysfunction and early atherosclerosis in humans. , 1995, Circulation.

[31]  F. Crea,et al.  Mechanisms of adenosine-induced epicardial coronary artery dilatation. , 1997, European heart journal.

[32]  R. Weston,et al.  LUNG CANCER AND SMOKING IN SWITZERLAND. , 1965, Lancet.

[33]  P. Vanhoutte,et al.  Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle. , 1986, The American journal of physiology.

[34]  D. Harrison,et al.  Hypercholesterolemia increases endothelial superoxide anion production. , 1993, The Journal of clinical investigation.

[35]  P. Camici,et al.  Role of positron emission tomography in the investigation of human coronary circulatory function. , 1994, Cardiovascular research.

[36]  P. Collins Coronary flow reserve. , 1993, British heart journal.

[37]  N. Flavahan,et al.  Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries. , 1991, Circulation.

[38]  W. Mayhan Endothelium-dependent responses of cerebral arterioles to adenosine 5'-diphosphate. , 1992, Journal of vascular research.

[39]  Adriaan A. Lammertsma,et al.  Measurement of myocardial blood flow with oxygen-15 labelled water: comparison of different administration protocols , 1998, European Journal of Nuclear Medicine.

[40]  M. Schwaiger,et al.  Delayed response of myocardial flow reserve to lipid-lowering therapy with fluvastatin. , 1999, Circulation.

[41]  P. Camici,et al.  Relation between myocardial blood flow and the severity of coronary-artery stenosis. , 1994, The New England journal of medicine.

[42]  Gambling with cardiovascular risk: picking the winners and the losers , 1999, The Lancet.

[43]  J. Cooke,et al.  L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. , 1992, The Journal of clinical investigation.

[44]  G. Diamond,et al.  Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. , 1979, The New England journal of medicine.

[45]  A. Maseri,et al.  Delayed recovery of coronary resistive vessel function after coronary angioplasty. , 1993, Journal of the American College of Cardiology.

[46]  A. Maseri,et al.  Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina. , 1991, The New England journal of medicine.

[47]  A. Yeung,et al.  The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. , 1995, The New England journal of medicine.

[48]  J. Yap,et al.  Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with 15O-labeled water and PET. , 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[49]  A. Nitenberg,et al.  Impairment of Coronary Vascular Reserve and ACh-Induced Coronary Vasodilation in Diabetic Patients With Angiographically Normal Coronary Arteries and Normal Left Ventricular Systolic Function , 1993, Diabetes.

[50]  K. Bruckdorfer,et al.  Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta , 1987, Nature.

[51]  D. Bhatnagar,et al.  Indications for cholesterol-lowering medication: comparison of risk-assessment methods , 1999, The Lancet.

[52]  E. Nabel,et al.  Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test. , 1988, Circulation.

[53]  Michael E. Phelps,et al.  Dynamic, Gated and High Resolution Imaging with the ECAT III , 1986, IEEE Transactions on Nuclear Science.

[54]  B. Hoffman,et al.  Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. , 1992, The Journal of clinical investigation.

[55]  M. Creager,et al.  Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans. , 1995, Circulation.

[56]  W. Weintraub,et al.  Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. , 1995, The New England journal of medicine.

[57]  H. Drexler,et al.  Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine , 1991, The Lancet.

[58]  S. Nees The adenosine hypothesis of metabolic regulation of coronary flow in the light of newly recognized properties of the coronary endothelium. , 1989, Zeitschrift fur Kardiologie.

[59]  T. Lehtimäki,et al.  Linkage of familial combined hyperlipidaemia to chromosome 1q21–q23 , 1998, Nature Genetics.

[60]  E. Anggard,et al.  Vitamin E protects against impairment of endothelium-mediated relaxations in cholesterol-fed rabbits. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[61]  B. F. Becker,et al.  Different endothelial mechanisms involved in coronary responses to known vasodilators. , 1992, The American journal of physiology.

[62]  L. Kuo,et al.  LDLs impair vasomotor function of the coronary microcirculation: role of superoxide anions. , 1998, Circulation research.

[63]  P. Gwirtz,et al.  Alpha 1-adrenergic constriction limits coronary flow and cardiac function in running dogs. , 1986, The American journal of physiology.

[64]  B. Folkow "Structural factor" in primary and secondary hypertension. , 1990, Hypertension.

[65]  K. Kugiyama,et al.  Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. , 1993, Circulation research.

[66]  O. Hess,et al.  Influence of Serum Cholesterol and Other Coronary Risk Factors on Vasomotion of Angiographically Normal Coronary Arteries , 1993, Circulation.

[67]  P. Kaufmann,et al.  Reversal of abnormal coronary vasomotion by calcium antagonists in patients with hypercholesterolemia. , 1998, Circulation.

[68]  G W Hamilton,et al.  Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve. , 1974, The American journal of cardiology.

[69]  D. Hay,et al.  Call for action. , 1971, Nursing mirror and midwives journal.

[70]  M. Omata,et al.  Reduced coronary flow reserve in hypercholesterolemic patients without overt coronary stenosis. , 1996, Circulation.

[71]  J. Viikari,et al.  Coronary flow reserve in young men with familial combined hyperlipidemia. , 1999, Circulation.

[72]  James P. Martucci,et al.  Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease. A potential noninvasive marker of healing coronary endothelium. , 1994, Circulation.

[73]  A. Lerman,et al.  Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. , 1991, The New England journal of medicine.

[74]  A. Yeung,et al.  Endothelium-dependent coronary vasomotion relates to the susceptibility of LDL to oxidation in humans. , 1996, Circulation.

[75]  M. Sugimachi,et al.  Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia. , 1994, Circulation.

[76]  C. Lau,et al.  Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients , 1993, The Lancet.