Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery

Soft/flexible PEG-based polymer nanotubes released doxorubicin over a sustained period and reduced tumor growth in a metastatic breast cancer model.

[1]  B. Chiu,et al.  Clinical Considerations of Focal Drug Delivery in Cancer Treatment. , 2017, Current drug delivery.

[2]  A. Karataş,et al.  Template Synthesis of Tubular Nanostructures for Loading Biologically Active Molecules. , 2017, Current topics in medicinal chemistry.

[3]  A. Sahebkar,et al.  The most prevalent side effects of pegylated liposomal doxorubicin monotherapy in women with metastatic breast cancer: a systematic review of clinical trials , 2017, Cancer Gene Therapy.

[4]  S. Galvagno,et al.  Tunable doxorubicin release from polymer-gated multiwalled carbon nanotubes. , 2016, International journal of pharmaceutics.

[5]  P. Kantoff,et al.  Cancer nanomedicine: progress, challenges and opportunities , 2016, Nature Reviews Cancer.

[6]  D. Kaplan,et al.  Heparin-Modified Polyethylene Glycol Microparticle Aggregates for Focal Cancer Chemotherapy. , 2016, ACS biomaterials science & engineering.

[7]  B. Newland,et al.  Preparation, loading, and cytotoxicity analysis of polymer nanotubes from an ethylene glycol dimethacrylate homopolymer in comparison to multi‐walled carbon nanotubes , 2016, Journal of interdisciplinary nanomedicine.

[8]  B. Newland,et al.  Magnetically Controllable Polymer Nanotubes from a Cyclized Crosslinker for Site-Specific Delivery of Doxorubicin , 2015, Scientific Reports.

[9]  Jens Friedrichs,et al.  Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis. , 2015, Biomaterials.

[10]  Steffen Dickopf,et al.  A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis , 2015, Nature.

[11]  B. Reid,et al.  PEG hydrogel degradation and the role of the surrounding tissue environment , 2015, Journal of tissue engineering and regenerative medicine.

[12]  E. Cosgriff-Hernandez,et al.  Determination of the in vivo degradation mechanism of PEGDA hydrogels. , 2014, Journal of biomedical materials research. Part A.

[13]  B. Aslim,et al.  Fabrication and modification of composite silica nano test tubes for targeted drug delivery , 2014 .

[14]  Randolph P. Martin,et al.  Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab. , 2014, Journal of the American College of Cardiology.

[15]  G. Dubini,et al.  A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone. , 2014, Biomaterials.

[16]  S. Lenaghan,et al.  Doxorubicin-loaded cyclic peptide nanotube bundles overcome chemoresistance in breast cancer cells. , 2014, Journal of biomedical nanotechnology.

[17]  Maurizio Prato,et al.  Endowing carbon nanotubes with biological and biomedical properties by chemical modifications. , 2013, Advanced drug delivery reviews.

[18]  Mingwu Shen,et al.  Targeted and pH‐Responsive Delivery of Doxorubicin to Cancer Cells Using Multifunctional Dendrimer‐Modified Multi‐Walled Carbon Nanotubes , 2013, Advanced healthcare materials.

[19]  Y. Liu,et al.  Understanding the toxicity of carbon nanotubes. , 2013, Accounts of chemical research.

[20]  D. Kaplan,et al.  Doxorubicin-loaded silk films: drug-silk interactions and in vivo performance in human orthotopic breast cancer. , 2012, Biomaterials.

[21]  M. Grinstaff,et al.  Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[22]  B. Newland,et al.  Single cyclized molecule versus single branched molecule: a simple and efficient 3D "knot" polymer structure for nonviral gene delivery. , 2012, Journal of the American Chemical Society.

[23]  Jillian L Perry,et al.  Drug-delivery strategies by using template-synthesized nanotubes. , 2011, Chemistry.

[24]  A. Balmain,et al.  Guidelines for the welfare and use of animals in cancer research , 2010, British Journal of Cancer.

[25]  Bing Yan,et al.  Endosomal leakage and nuclear translocation of multiwalled carbon nanotubes: developing a model for cell uptake. , 2009, Nano letters.

[26]  Zhuang Liu,et al.  Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy. , 2009, Angewandte Chemie.

[27]  Stephanie J Bryant,et al.  Characterization of the in vitro macrophage response and in vivo host response to poly(ethylene glycol)-based hydrogels. , 2009, Journal of biomedical materials research. Part A.

[28]  Max Whitby,et al.  Enhanced fluid flow through nanoscale carbon pipes. , 2008, Nano letters.

[29]  Kostas Kostarelos,et al.  The long and short of carbon nanotube toxicity , 2008, Nature Biotechnology.

[30]  R. Cavicchi,et al.  Anti-HER2 IgY antibody-functionalized single-walled carbon nanotubes for detection and selective destruction of breast cancer cells , 2008, BMC Cancer.

[31]  Hongjie Dai,et al.  Supramolecular Chemistry on Water- Soluble Carbon Nanotubes for Drug Loading and Delivery , 2007 .

[32]  M. Prato,et al.  Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. , 2007, Nature nanotechnology.

[33]  C. R. Martin,et al.  Template synthesized nanotubes for biomedical delivery applications. , 2006, Nanomedicine.

[34]  Jiahai Wang,et al.  Template-synthesized protein nanotubes. , 2005, Nano letters.

[35]  A. Greiner,et al.  Polymer Nanotubes by Wetting of Ordered Porous Templates , 2002, Science.

[36]  J. Marotta,et al.  Intratumoral cancer chemotherapy and immunotherapy: opportunities for nonsystemic preoperative drug delivery , 2002, The Journal of pharmacy and pharmacology.

[37]  E. Winer,et al.  Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer. , 2001, Journal of the National Cancer Institute. Monographs.

[38]  M. Gottesman,et al.  Multidrug resistance in cancer: role of ATP–dependent transporters , 2002, Nature Reviews Cancer.