Inhibition of human CYP2B6 by N,N',N''-triethylenethiophosphoramide is irreversible and mechanism-based.
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[1] J. Rae,et al. Metabolism of N,N′,N″-Triethylenethiophosphoramide by CYP2B1 and CYP2B6 Results in the Inactivation of Both Isoforms by Two Distinct Mechanisms , 2004, Journal of Pharmacology and Experimental Therapeutics.
[2] M. Eichelbaum,et al. Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine , 2004, Journal of Pharmacology and Experimental Therapeutics.
[3] P. Beaune,et al. Induction of Cytochrome P450 2B6 and 3A4 Expression by Phenobarbital and Cyclophosphamide in Cultured Human Liver Slices , 2003, Pharmaceutical Research.
[4] Steven J M Jones,et al. Influence of scheduling on two-drug combinations of alkylating agents in vivo , 2004, Cancer Chemotherapy and Pharmacology.
[5] C. Vecht,et al. Interactions between antiepileptic and chemotherapeutic drugs , 2003, The Lancet Neurology.
[6] G. Ferron,et al. Quantitation of cytochrome P450 mRNA levels in human skin. , 2003, Analytical biochemistry.
[7] U. Yasar,et al. Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation , 2003, The Pharmacogenomics Journal.
[8] D. Flockhart,et al. Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[9] A. Birnbaum,et al. Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA , 2002, Cancer Chemotherapy and Pharmacology.
[10] S. Hall,et al. Mechanism-Based Inhibition of Human Cytochromes P450: In Vitro Kinetics and In Vitro—In Vivo Correlations , 2001 .
[11] A. D. Rodrigues,et al. Drug-drug interactions , 2001, Atkinson's Principles of Clinical Pharmacology.
[12] I. Phillips,et al. Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450. , 2001, Biochemical pharmacology.
[13] U. Hofmann,et al. Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. , 2001, Pharmacogenetics.
[14] D. Greenblatt,et al. CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants. , 2000, Drug metabolism and disposition: the biological fate of chemicals.
[15] C. Lindley,et al. Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. , 2000, Drug metabolism and disposition: the biological fate of chemicals.
[16] J. Beijnen,et al. Chemistry, pharmacology and pharmacokinetics of N,N',N" -triethylenethiophosphoramide (ThioTEPA). , 2000, Cancer treatment reviews.
[17] S. Rodenhuis,et al. Reduction of cyclophosphamide bioactivation by thioTEPA: critical sequence-dependency in high-dose chemotherapy regimens , 2000, Cancer Chemotherapy and Pharmacology.
[18] M O Karlsson,et al. A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients. , 1999, British journal of clinical pharmacology.
[19] S. Srivastava,et al. Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa. , 1999, Archives of biochemistry and biophysics.
[20] D. Waxman,et al. Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[21] A. Y. Lu,et al. Inhibition and Induction of Cytochrome P450 and the Clinical Implications , 1998, Clinical pharmacokinetics.
[22] F. Appelbaum,et al. Pharmacokinetics of cyclophosphamide and its metabolites in bone marrow transplantation patients , 1998, Clinical pharmacology and therapeutics.
[23] J. Peterse,et al. Randomised trial of high-dose chemotherapy and haemopoietic progenitor-cell support in operable breast cancer with extensive axillary lymph-node involvement , 1998, The Lancet.
[24] D. Flockhart,et al. Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6. , 1998, Drug metabolism and disposition: the biological fate of chemicals.
[25] J. Wingard,et al. Minimal toxicity and mortality in high-risk breast cancer patients receiving high-dose cyclophosphamide, thiotepa, and carboplatin plus autologous marrow/stem-cell transplantation and comprehensive supportive care. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[26] D. Berry,et al. A phase I/II study of high-dose cyclophosphamide, cisplatin, and thioTEPA followed by autologous bone marrow and granulocyte colony-stimulating factor-primed peripheral-blood progenitor cells in patients with advanced malignancies , 1996, Cancer Chemotherapy and Pharmacology.
[27] S. Rodenhuis,et al. High-dose chemotherapy regimens for solid tumors. , 1995, Cancer treatment reviews.
[28] E. Wall. High dose chemotherapy for solid tumors , 1995 .
[29] R. Silverman. Mechanism-based enzyme inactivators. , 1995, Methods in enzymology.
[30] A. Deisseroth,et al. A phase I-II study of high-dose thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic marrow transplantation. , 1994, Bone marrow transplantation.
[31] G. F. Weber,et al. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. , 1993, Cancer research.
[32] M. Dimopoulos,et al. Thiotepa, busulfan, and cyclophosphamide: a new preparative regimen for autologous marrow or blood stem cell transplantation in high-risk multiple myeloma. , 1993, Blood.
[33] P. Engstrom,et al. Phase I/pharmacokinetic reevaluation of thioTEPA. , 1991, Cancer research.
[34] D. Waxman,et al. N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents. , 1991, Cancer research.
[35] D. Waxman,et al. Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase. , 1990, Cancer research.
[36] P. Beaune,et al. Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[37] R. A. Neal,et al. Inactivation of purified rat liver cytochrome P-450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate). , 1980, The Journal of biological chemistry.