Canagliflozin attenuates thioacetamide-induced liver injury through modulation of HMGB1/RAGE/TLR4 signaling pathways.

[1]  G. Schiattarella,et al.  Canagliflozin and myocardial oxidative stress: SGLT1 inhibition takes centre stage. , 2021, European heart journal.

[2]  M. Karck,et al.  The Sodium-Glucose Cotransporter-2 Inhibitor Canagliflozin Alleviates Endothelial Dysfunction Following In Vitro Vascular Ischemia/Reperfusion Injury in Rats , 2021, International journal of molecular sciences.

[3]  N. Younis,et al.  RETRACTED ARTICLE: Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway , 2021, Scientific Reports.

[4]  C. Miao,et al.  Sevoflurane Postconditioning Attenuates Hepatic Ischemia-Reperfusion Injury by Limiting HMGB1/TLR4/NF-κB Pathway via Modulating microRNA-142 in vivo and in vitro , 2021, Frontiers in Pharmacology.

[5]  Sahar S. Abd El-Rahman,et al.  Promoted inhibition of TLR4/miR-155/ NFkB p65 signaling by Cannabinoid receptor 2 agonist (AM1241), aborts inflammation and progress of hepatic fibrosis induced by thioacetamide. , 2021, Chemico-biological interactions.

[6]  Bin Liu,et al.  Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-δ in sepsis-associated liver injury , 2020, Cell Death & Disease.

[7]  J. Hermanides,et al.  Novel Anti-inflammatory Effects of Canagliflozin Involving Hexokinase II in Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells , 2020, Cardiovascular Drugs and Therapy.

[8]  Farzana Zerin,et al.  Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK–Akt–eNOS pathway in the isoprenaline-induced oxidative stress model , 2020, Scientific Reports.

[9]  Farzana Zerin,et al.  Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways , 2020, Scientific Reports.

[10]  X. Xia,et al.  Kaempferol from Penthorum chinense Pursh suppresses HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation in acetaminophen-induced hepatotoxicity. , 2020, Food & function.

[11]  Xiangcheng Zhang,et al.  HMGB1 mediates acute liver injury in sepsis through pyroptosis of liver macrophages. , 2020, International journal of burns and trauma.

[12]  Z. Dong,et al.  Canagliflozin reduces cisplatin uptake and activates Akt to protect against cisplatin-induced nephrotoxicity. , 2020, American journal of physiology. Renal physiology.

[13]  H. Yoshiji,et al.  Combined Treatment with Sodium-Glucose Cotransporter-2 Inhibitor (Canagliflozin) and Dipeptidyl Peptidase-4 Inhibitor (Teneligliptin) Alleviates NASH Progression in A Non-Diabetic Rat Model of Steatohepatitis , 2020, International journal of molecular sciences.

[14]  Der-Shan Sun,et al.  Thioacetamide-induced liver damage and thrombocytopenia is associated with induction of antiplatelet autoantibody in mice , 2019, Scientific Reports.

[15]  H. Fayed,et al.  Targeting AngII/AT1R signaling pathway by perindopril inhibits ongoing liver fibrosis in rat , 2019, Journal of tissue engineering and regenerative medicine.

[16]  A. K. A. Abdel Latif,et al.  Effect of Canagliflozin, an SGLT2 Inhibitor, in Comparison with Atorvastatin on Dexamethasone-Induced Hepatic Steatosis in Albino Rats , 2019 .

[17]  Y. Aso,et al.  The SGLT2 Inhibitor Canagliflozin Prevents Carcinogenesis in a Mouse Model of Diabetes and Non-Alcoholic Steatohepatitis-Related Hepatocarcinogenesis: Association with SGLT2 Expression in Hepatocellular Carcinoma , 2019, International journal of molecular sciences.

[18]  Luwen Wang,et al.  Protective role of AGK2 on thioacetamide-induced acute liver failure in mice. , 2019, Life sciences.

[19]  M. Murphy,et al.  The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion. , 2019, Biochimica et biophysica acta. Molecular basis of disease.

[20]  O. Kim,et al.  The Role of Phospho-c-Jun N-Terminal Kinase Expression on hepatocyte Necrosis and Autophagy in the Cholestatic Liver. , 2019, The Journal of surgical research.

[21]  Samaneh Noroozi,et al.  A Review on the Structure and Function of Liver from Avicenna Point of View and Its Comparison with Conventional Medicine , 2019, Traditional and Integrative Medicine.

[22]  P. Kamath,et al.  Burden of liver diseases in the world. , 2019, Journal of hepatology.

[23]  A. Shalaby,et al.  Effect of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on cisplatin-induced nephrotoxicity in mice , 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

[24]  N. Nieto,et al.  High‐Mobility Group Box‐1 and Liver Disease , 2018, Hepatology communications.

[25]  Soad L Kabil,et al.  Canagliflozin protects against non‐alcoholic steatohepatitis in type‐2 diabetic rats through zinc alpha‐2 glycoprotein up‐regulation , 2018, European journal of pharmacology.

[26]  T. Palmer,et al.  Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms , 2018, Scientific Reports.

[27]  K. Tsuchiya,et al.  Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH , 2018, Scientific Reports.

[28]  J. Wan,et al.  Glycyrrhetinic acid prevents acetaminophen‐induced acute liver injury via the inhibition of CYP2E1 expression and HMGB1‐TLR4 signal activation in mice , 2017, International immunopharmacology.

[29]  Y. Tajima,et al.  HMGB1 is a promising therapeutic target for acute liver failure , 2017, Expert review of gastroenterology & hepatology.

[30]  O. Dirsch,et al.  Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1‐mediated deacetylation of high‐mobility group box 1 in rats , 2017, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[31]  R. Venkataramanan,et al.  Drug Metabolism in the Liver. , 2017, Clinics in liver disease.

[32]  Yi-Bing Hu,et al.  Correlation between high mobility group box-1 protein and chronic hepatitis B infection with severe hepatitis B and acute-on-chronic liver failure: a meta-analysis. , 2016, Minerva medica.

[33]  P. Sil,et al.  Silymarin Protects Mouse Liver and Kidney from Thioacetamide Induced Toxicity by Scavenging Reactive Oxygen Species and Activating PI3K-Akt Pathway , 2016, Front. Pharmacol..

[34]  M. R. Talluri,et al.  Thioacetamide-induced acute liver toxicity in rats treated with Balanites roxburghii extracts , 2016 .

[35]  7. Approaches to Glycemic Treatment , 2015, Diabetes Care.

[36]  Lei Dong,et al.  Protective effects of pentoxifylline on acute liver injury induced by thioacetamide in rats. , 2015, International journal of clinical and experimental pathology.

[37]  K. Kodys,et al.  Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice , 2015, Journal of Translational Medicine.

[38]  S. Friedman,et al.  Standard Operating Procedures in Experimental Liver Research: Thioacetamide model in mice and rats , 2015, Laboratory animals.

[39]  S. Yamagishi,et al.  Role of receptor for advanced glycation end products (RAGE) in liver disease , 2015, European Journal of Medical Research.

[40]  S. Reddy,et al.  Reactive oxygen species in inflammation and tissue injury. , 2014, Antioxidants & redox signaling.

[41]  Wen Hou,et al.  Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases , 2013, Molecular Medicine.

[42]  U. Moens,et al.  The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation , 2013, Genes.

[43]  J. Wendon,et al.  Acute liver failure. , 2013, The New England journal of medicine.

[44]  Sheng Liu,et al.  High-Mobility Group Box-1 Induces Proinflammatory Cytokines Production of Kupffer Cells through TLRs-Dependent Signaling Pathway after Burn Injury , 2012, PloS one.

[45]  B. Rajkapoor,et al.  Protective effect of Pisonia aculeata on thioacetamide induced hepatotoxicity in rats. , 2012, Asian Pacific journal of tropical biomedicine.

[46]  Mitchell R. McGill,et al.  Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. , 2012, Journal of hepatology.

[47]  J. González‐Gallego,et al.  Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats , 2011, Toxicologic pathology.

[48]  J. A. Nogueira-Machado,et al.  HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation , 2011, Expert opinion on therapeutic targets.

[49]  I. N. Crispe,et al.  TLRs in Hepatic Cellular Crosstalk , 2010, Gastroenterology research and practice.

[50]  A. Coyle,et al.  HMGB1 and RAGE in inflammation and cancer. , 2010, Annual review of immunology.

[51]  A. Higure,et al.  Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia , 2009, Critical care medicine.

[52]  M. Uysal,et al.  Role of carnosine in preventing thioacetamide-induced liver injury in the rat , 2008, Peptides.

[53]  Arjan W. Griffioen,et al.  Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1) , 2008, Angiogenesis.

[54]  A. Cuenda,et al.  p38 MAP-kinases pathway regulation, function and role in human diseases. , 2007, Biochimica et biophysica acta.

[55]  E. Abraham,et al.  High mobility group box 1 protein interacts with multiple Toll-like receptors. , 2006, American journal of physiology. Cell physiology.

[56]  M. Bianchi,et al.  Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation , 2004, The Journal of cell biology.

[57]  Hong Wang,et al.  Structural Basis for the Proinflammatory Cytokine Activity of High Mobility Group Box 1 , 2003, Molecular medicine.

[58]  J. Youngson,et al.  Comparison of different scoring systems for immunohistochemical staining. , 1999, Journal of clinical pathology.

[59]  J. Guesdon,et al.  The use of avidin-biotin interaction in immunoenzymatic techniques. , 1979, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[60]  K. Yagi,et al.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. , 1979, Analytical biochemistry.

[61]  S. Marklund,et al.  Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. , 1974, European journal of biochemistry.

[62]  G. Ellman,et al.  Tissue sulfhydryl groups. , 1959, Archives of biochemistry and biophysics.