Wireless Controlled Local Heating and Mixing Multiple Droplets Using Micro-Fabricated Resonator Array for Micro-Reactor Applications

This paper reported a wireless controlled micro-actuator system for rapid heating and mixing of multiple droplets using integrated arrays of micro-fabricated 2.5 GHz solid-mounted thin-film piezoelectric resonators (SMRs) and a millimeter-scale omnidirectional antenna. An equivalent circuit is proposed to analyze the mechanism of the heating, mixing of the SMR, and the wireless communication system. The heating and mixing rate can be tuned by adjusting the input power as well as the transmission distance between the transmitting antenna and the receiving antennas. A heating rate up to 3.7 °C per second and ultra-fast mixing of the droplet was demonstrated with the wireless microsystem. In addition, two types of circuits, H-shaped and rake-shaped, were designed and fabricated for parallel operating actuator array and controlling the power distribution with the array. Both uniform and gradient heating of the multiple droplets are achieved, which can be potentially applied for developing high-throughput wireless micro-reactor system.

[1]  Jung-Hwan Park,et al.  Wireless induction heating in a microfluidic device for cell lysis. , 2010, Lab on a chip.

[2]  Xing Chen,et al.  Wirelessly addressable heater array for centrifugal microfluidics and escherichia coli sterilization , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[3]  E. S. Kim,et al.  Label-free detection of protein-ligand interactions in real time using micromachined bulk acoustic resonators , 2010 .

[4]  Darwin R. Reyes,et al.  Microwave dielectric heating of fluids in an integrated microfluidic device , 2007 .

[5]  T. Yokoyama,et al.  Development of Piezoelectric Thin Film Resonator and Its Impact on Future Wireless Communication Systems , 2005 .

[6]  B. Musselman,et al.  Direct analysis in real time for reaction monitoring in drug discovery. , 2007, Analytical chemistry.

[7]  Marwan Nafea,et al.  Thermal analysis of wirelessly powered thermo-pneumatic micropump based on planar LC circuit , 2016 .

[8]  Nam-Trung Nguyen,et al.  High-throughput micromixers based on acoustic streaming induced by surface acoustic wave , 2011 .

[9]  Tuncay Alan,et al.  Vibrating membrane with discontinuities for rapid and efficient microfluidic mixing. , 2015, Lab on a chip.

[10]  Wei Pang,et al.  Localized ultrahigh frequency acoustic fields induced micro-vortices for submilliseconds microfluidic mixing , 2016 .

[11]  Kendall N Houk,et al.  Rapid catalyst identification for the synthesis of the pyrimidinone core of HIV integrase inhibitors. , 2012, Angewandte Chemie.

[12]  E. S. Kim,et al.  Subpicoliter droplet generation based on a nozzle-free acoustic transducer , 2008 .

[13]  Wei Pang,et al.  Microchip based electrochemical-piezoelectric integrated multi-mode sensing system for continuous glucose monitoring , 2016 .

[14]  W. Pang,et al.  On-chip integrated multiple microelectromechanical resonators to enable the local heating, mixing and viscosity sensing for chemical reactions in a droplet , 2017 .

[15]  Albert P. Pisano,et al.  Thermally compensated aluminum nitride Lamb wave resonators for high temperature applications , 2010 .

[16]  A. Abate,et al.  Ultrahigh-throughput screening in drop-based microfluidics for directed evolution , 2010, Proceedings of the National Academy of Sciences.

[17]  K. Jensen Microreaction engineering * is small better? , 2001 .

[18]  S. Quake,et al.  Microfluidic Large-Scale Integration , 2002, Science.

[19]  David Issadore,et al.  Microwave dielectric heating of drops in microfluidic devices. , 2009, Lab on a chip.

[20]  V. Studer,et al.  An integrated AC electrokinetic pump in a microfluidic loop for fast and tunable flow control. , 2004, The Analyst.

[21]  A. Manz,et al.  Lab-on-a-chip: microfluidics in drug discovery , 2006, Nature Reviews Drug Discovery.

[22]  Shin Wakitani,et al.  Operator based fault detection and isolation for microreactor actuated by Peltier devices , 2015, 2015 IEEE 12th International Conference on Networking, Sensing and Control.

[23]  J. Friend,et al.  Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics , 2011 .

[24]  Janos Vörös,et al.  Comparison of FBAR and QCM-D sensitivity dependence on adlayer thickness and viscosity , 2011 .

[25]  Monica Brivio,et al.  Miniaturized continuous flow reaction vessels: influence on chemical reactions. , 2006, Lab on a chip.

[26]  Juan G. Santiago,et al.  Design sensitivity and mixing uniformity of a micro-fluidic mixer , 2016 .

[27]  Kofi Asante,et al.  A MEMS-Based Catalytic Microreactor for a H$_{\bf 2}$ O$_{\bf 2}$ Monopropellant Micropropulsion System , 2013, IEEE/ASME Transactions on Mechatronics.

[28]  Tassos G. Karayiannis,et al.  Nucleation site interaction between artificial cavities during nucleate pool boiling on silicon with integrated micro-heater and temperature micro-sensors , 2012 .