53BP1-mediated DNA double strand break repair: insert bad pun here.

[1]  P. Jeggo,et al.  KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response , 2011, Nature Structural &Molecular Biology.

[2]  M. Nussenzweig,et al.  Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. , 2011, Molecular cell.

[3]  D. Ferguson,et al.  Chfr and RNF8 synergistically regulate ATM activation , 2011, Nature Structural &Molecular Biology.

[4]  D. Durocher,et al.  Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE Syndrome , 2011, PLoS genetics.

[5]  C. Doil,et al.  Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia , 2011, Cell Death and Differentiation.

[6]  P. Jeggo,et al.  The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax. , 2010, DNA repair.

[7]  T. Honjo,et al.  Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination , 2010, Proceedings of the National Academy of Sciences.

[8]  Liewei Wang,et al.  MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites , 2010, Nature.

[9]  B. L. Sibanda,et al.  Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining , 2010, Journal of nucleic acids.

[10]  D. Adams,et al.  53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers , 2010, Nature Structural &Molecular Biology.

[11]  Olivia Barton,et al.  Role of ATM and the Damage Response Mediator Proteins 53BP1 and MDC1 in the Maintenance of G2/M Checkpoint Arrest , 2010, Molecular and Cellular Biology.

[12]  Jeremy M. Stark,et al.  53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks , 2010, Cell.

[13]  P. Jeggo,et al.  53BP1 promotes ATM activity through direct interactions with the MRN complex , 2010, The EMBO journal.

[14]  A. Shibata,et al.  53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair , 2010, Nature Cell Biology.

[15]  Markus Löbrich,et al.  ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2 , 2009, The EMBO journal.

[16]  C. Deng,et al.  A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. , 2009, Molecular cell.

[17]  T. de Lange,et al.  Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G1 and Resection-Mediated Inhibition of NHEJ in G2 , 2009, Molecular and Cellular Biology.

[18]  A. Khamlichi,et al.  S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination , 2009, The Journal of experimental medicine.

[19]  M. Lieber,et al.  H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations. , 2009, Molecular cell.

[20]  M. Scharff,et al.  H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination , 2009, Proceedings of the National Academy of Sciences.

[21]  Edward S. Miller,et al.  The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage , 2009, Cell.

[22]  J. Ellenberg,et al.  RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins , 2009, Cell.

[23]  S. Lees-Miller,et al.  Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. , 2009, The Biochemical journal.

[24]  D. Spector,et al.  53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility , 2008, Nature.

[25]  M. Nussenzweig,et al.  53BP1 facilitates long-range DNA end-joining during V(D)J recombination , 2008, Nature.

[26]  P. Russell,et al.  Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair , 2008, Cell.

[27]  M. Lavin,et al.  Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer , 2008, Nature Reviews Molecular Cell Biology.

[28]  P. Jeggo,et al.  ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. , 2008, Molecular cell.

[29]  C. E. Schrader,et al.  Mechanism and regulation of class switch recombination. , 2008, Annual review of immunology.

[30]  F. Alt,et al.  Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. , 2007, Molecular cell.

[31]  Michael B. Yaffe,et al.  RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly , 2007, Cell.

[32]  Jiri Bartek,et al.  RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins , 2007, Cell.

[33]  E. Selsing,et al.  Activation-Induced Cytidine Deaminase-Dependent DNA Breaks in Class Switch Recombination Occur during G1 Phase of the Cell Cycle and Depend upon Mismatch Repair1 , 2007, The Journal of Immunology.

[34]  N. Kelleher,et al.  Certain and Progressive Methylation of Histone H4 at Lysine 20 during the Cell Cycle , 2007, Molecular and Cellular Biology.

[35]  Edward S. Miller,et al.  RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling , 2007, Proceedings of the National Academy of Sciences.

[36]  T. Lange,et al.  Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1 , 2007, Nature.

[37]  M. Nussenzweig,et al.  Enhanced intra‐switch region recombination during immunoglobulin class switch recombination in 53BP1–/– B cells , 2007, European journal of immunology.

[38]  Georges Mer,et al.  Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair , 2006, Cell.

[39]  Laurence H Pearl,et al.  Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. , 2006, Molecular cell.

[40]  S. Lees-Miller,et al.  Analysis of DNA-dependent protein kinase-mediated DNA end joining by two-photon fluorescence cross-correlation spectroscopy. , 2006, Biochemistry.

[41]  S. Elledge,et al.  53BP1 Oligomerization is Independent of its Methylation by PRMT1 , 2005, Cell cycle.

[42]  F. Boisvert,et al.  The GAR Motif of 53BP1 is Arginine Methylated by PRMT1 and is Necessary for 53BP1 DNA Binding Activity , 2005, Cell cycle.

[43]  C. Dekker,et al.  Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA , 2005, Nature.

[44]  C. E. Schrader,et al.  Inducible DNA breaks in Ig S regions are dependent on AID and UNG , 2005, The Journal of experimental medicine.

[45]  A. Corcoran.  Immunoglobulin locus silencing and allelic exclusion. , 2005, Seminars in immunology.

[46]  Martin Kühne,et al.  A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. , 2004, Molecular cell.

[47]  Tom J. Petty,et al.  Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks , 2004, Nature.

[48]  G. Almouzni,et al.  Mouse centric and pericentric satellite repeats form distinct functional heterochromatin , 2004, The Journal of cell biology.

[49]  F. Alt,et al.  53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination , 2004, Nature Immunology.

[50]  P. Jeggo,et al.  Potential Role for 53BP1 in DNA End-joining Repair through Direct Interaction with DNA* , 2003, Journal of Biological Chemistry.

[51]  M. Nussenzweig,et al.  H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation , 2003, The Journal of experimental medicine.

[52]  S. Elledge,et al.  Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability* , 2003, The Journal of Biological Chemistry.

[53]  Junjie Chen,et al.  p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice , 2003, Molecular and Cellular Biology.

[54]  A. Nussenzweig,et al.  DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1 , 2002, Nature Cell Biology.

[55]  Michel C. Nussenzweig,et al.  Genomic Instability in Mice Lacking Histone H2AX , 2002, Science.

[56]  Yunmei Ma,et al.  Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination , 2002, Cell.

[57]  Junjie Chen,et al.  Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways , 2001, The Journal of cell biology.

[58]  Y. Adachi,et al.  Phosphorylation and Rapid Relocalization of 53BP1 to Nuclear Foci upon DNA Damage , 2001, Molecular and Cellular Biology.

[59]  T. Halazonetis,et al.  P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks , 2000, The Journal of cell biology.

[60]  T. Honjo,et al.  Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme , 2000, Cell.

[61]  S. Fields,et al.  Two cellular proteins that bind to wild-type but not mutant p53. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[62]  P. Huertas,et al.  DNA resection in eukaryotes: deciding how to fix the break , 2010, Nature Structural &Molecular Biology.

[63]  N. Mailand,et al.  HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes , 2010, Nature Cell Biology.

[64]  M. Gellert.  V(D)J recombination: RAG proteins, repair factors, and regulation. , 2002, Annual review of biochemistry.