Genetics, biochemistry and structure of the archaeal virus STIV.

STIV (Sulfolobus turreted icosahedral virus) has been the subject of detailed structural, genetic, transcriptomic, proteomic and biochemical studies. STIV arguably has been investigated in more detail than any other archaeal virus. As a result, we know more about STIV than other viruses infecting members of the Archaea domain. Like most viruses isolated from crenarchaeal hosts, STIV has little in common with viruses that infect eukaryotic and bacterial hosts and should be considered the founding member of a new virus family. However, despite this lack of obvious homology with other viruses, STIV has components of gene content, replication strategy and particle structure reminiscent of viruses of the Eukarya and Bacteria domains, suggesting an evolutionary relationship between viruses from all domains of life. The present mini-review describes the current knowledge of this virus and insights it has given us into viral and cellular evolution, as well as newly developed tools for the further study of STIV-host interactions.

[1]  Stan J. J. Brouns,et al.  Transcriptome Analysis of Infection of the Archaeon Sulfolobus solfataricus with Sulfolobus Turreted Icosahedral Virus , 2008, Journal of Virology.

[2]  M. Young,et al.  A winged-helix protein from Sulfolobus turreted icosahedral virus points toward stabilizing disulfide bonds in the intracellular proteins of a hyperthermophilic virus. , 2007, Virology.

[3]  M. Young,et al.  A new DNA binding protein highly conserved in diverse crenarchaeal viruses. , 2007, Virology.

[4]  S. Albers,et al.  Small multicopy, non-integrative shuttle vectors based on the plasmid pRN1 for Sulfolobus acidocaldarius and Sulfolobus solfataricus, model organisms of the (cren-)archaea , 2007, Nucleic acids research.

[5]  R. Garrett,et al.  Viruses of the Archaea: a unifying view , 2006, Nature Reviews Microbiology.

[6]  M. Young,et al.  Characterization of the Archaeal Thermophile Sulfolobus Turreted Icosahedral Virus Validates an Evolutionary Link among Double-Stranded DNA Viruses from All Domains of Life , 2006, Journal of Virology.

[7]  M. Young,et al.  Structure of A197 from Sulfolobus Turreted Icosahedral Virus: a Crenarchaeal Viral Glycosyltransferase Exhibiting the GT-A Fold , 2006, Journal of Virology.

[8]  N. Grishin,et al.  A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action , 2006, Biology Direct.

[9]  T. Urich,et al.  Production of Recombinant and Tagged Proteins in the Hyperthermophilic Archaeon Sulfolobus solfataricus , 2006, Applied and Environmental Microbiology.

[10]  John E. Johnson,et al.  Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[11]  John E. Johnson,et al.  The structure of a thermophilic archaeal virus shows a double-stranded DNA viral capsid type that spans all domains of life. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[12]  C. Schleper,et al.  Genetic requirements for the function of the archaeal virus SSV1 in Sulfolobus solfataricus: construction and testing of viral shuttle vectors. , 1999, Genetics.

[13]  R. Garrett,et al.  Genetic elements in the extremely thermophilic archaeon Sulfolobus , 1998, Extremophiles.