Relationship of ventilation inhomogeneity to morphologic variables in excised human lungs.

Ventilation inhomogeneity, as assessed by the regional distribution of 133Xe and the single breath washout (SBW) curve, is compared with the morphologic aspects in excised human lungs. Morphologic measurements include central airway diameter, bronchial gland area, peripheral airway diameter, and the alveolar surface-to-volume ratio. Lung inflation with a constant concentration of 133Xe results in relatively more 133Xe distributed to the lung base than to the apex. Neither the vertical gradient in ventilation nor other interregional inhomogeneities in 133Xe distribution are correlated with morphologic variations in the lung. Also, interregional inhomogeneities of 133Xe distribution do not correlate with phase III slope of the SBW curve. This suggests that the phase III slope is determined primarily by intraregional ventilation inhomogeneities. Within the phase IV region of the SBW curve two distinct inflections are identified: an inflection at volume V1 and another sharper inflection at volume V2. Both the phase III slope and V2 correlate significantly (p less than 0.05) with peripheral airway diameter, indicating that parameters of the SBW curve do assess peripheral airway properties.

[1]  D. Niewoehner,et al.  Human lung pressure-volume relationships: alveolar collapse and airway closure. , 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

[2]  L. A. Engel,et al.  The anatomical basis for the sloping N2 plateau. , 1981, Respiration physiology.

[3]  T. Petty,et al.  Small airway pathology is related to increased closing capacity and abnormal slope of phase III in excised human lungs. , 2015, The American review of respiratory disease.

[4]  J Dosman,et al.  The relations between structural changes in small airways and pulmonary-function tests. , 1978, The New England journal of medicine.

[5]  D. Niewoehner,et al.  Peripheral airways as a determinant of ventilatory function in the human lung. , 1977, The Journal of clinical investigation.

[6]  R. Stanford,et al.  The morphologic features of the bronchi, bronchioles, and alveoli in chronic airway obstruction: a clinicopathologic study. , 1976, The American review of respiratory disease.

[7]  J. Ultman,et al.  Monte Carlo simulation of simultaneous gas flow and diffusion in an asymmetric distal pulmonary airway model. , 1976, Bulletin of mathematical biology.

[8]  L. Liotta,et al.  Elastic behavior of postmortem human lungs: effects of aging and mild emphysema. , 1975, Journal of applied physiology.

[9]  A. E. Anderson,et al.  Topology of nonrespiratory bronchioles of normal and emphysematous lungs. , 1974, Human pathology.

[10]  D. Niewoehner,et al.  Pathologic changes in the peripheral airways of young cigarette smokers. , 1974, The New England journal of medicine.

[11]  D. Niewoehner,et al.  Morphologic basis of pulmonary resistance in the human lung and effects of aging. , 1974, Journal of applied physiology.

[12]  B. B. Ross,et al.  A comparison of conventional spirometric tests and the test of closing volume in an emphysema screening center. , 1973, The American review of respiratory disease.

[13]  W. MacIntyre,et al.  Dynamic measurement of ventilation-perfusion with xenon-133 at resting lung volumes. , 1973, The American review of respiratory disease.

[14]  J Milic-Emili,et al.  Measurement of "closing volume" as a simple and sensitive test for early detection of small airway disease. , 1972, The American journal of medicine.

[15]  F L Matthews,et al.  Stresses, strains, and surface pressures in the lung caused by its weight. , 1972, Journal of applied physiology.

[16]  P. Sutherland,et al.  Previous volume history of the lung and regional distribution of gas. , 1968, Journal of applied physiology.

[17]  H. Ahrens,et al.  Brownlee, K. A.: Statistical Theory and Methodology in Science and Engineering. John Wiley & Sons, New York 1965, 590 S., 70 Abb., Tafelanhang , 1968 .

[18]  W. Dixon.  BMD : biomedical computer programs , 1967 .

[19]  D. M. Ellis,et al.  Applied Regression Analysis , 1968 .

[20]  D. G. Beech,et al.  Statistical Theory and Methodology in Science and Engineering. , 1961 .