论文信息 - Terahertz Time-Domain Spectroscopy of Glucose and Uric Acid

Terahertz Time-Domain Spectroscopy of Glucose and Uric Acid

We report the use ofterahertz time-domain spectroscopy for thestudy of two therapeutic bio-molecules:glucose and uric acid. Terahertztransmission spectra of crystalline samplesof both molecules were measured between 0.1–3.0 THz using an evacuated spectroscopysystem. We propose that the stereo-isomersof glucose show spectral featuresoriginating from intermolecular vibrationalmodes, as do uric acid and its derivativemolecule, allantoin. In addition, wepresent a full temperature dependence ofthe terahertz absorption of L-glucose.

[1] D. Kell,et al. The passive electrical properties of biological systems: their significance in physiology, biophysics and biotechnology. , 1987, Physics in medicine and biology.

[2] E. Heilweil,et al. Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz , 2000 .

[3] Hanspeter Helm,et al. Far-infrared vibrational spectra of all-trans, 9-cis and 13-cis retinal measured by THz time-domain spectroscopy , 2000 .

[4] B. Fischer,et al. Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy. , 2002, Biopolymers.

[5] B. Fischer,et al. Far-infrared spectroscopy of hydrogen bonding in nucleobases, nucleosides, and nucleotides , 2002, Proceedings, IEEE Tenth International Conference on Terahertz Electronics.

[6] D. Mittleman,et al. Propagation of single-cycle terahertz pulses in random media. , 2001, Optics letters.

[7] A. Davies,et al. Design and performance of a novel vacuum-capable terahertz time-domain spectrometer , 2002, Proceedings, IEEE Tenth International Conference on Terahertz Electronics.