Long-term potentiation in the interpositus and vestibular nuclei in the rat

SummaryPrevious unpublished experiments from this laboratory had revealed only post-activation depression effects in the cerebellar cortex when its inputs were activated by high frequency trains. In the experiments reported in this paper, we found reliable long-term potentiation (LTP) effects in the deep nuclei (interpositus and vestibular) when stimulation trains were applied to the white matter at the point where inferior peduncle fibers enter the cerebellum. LTP effects were found in both acute and chronic preparations. In the chronic preparations, LTP lasted for at least 8 days in all but one animal.

[1]  T. Bliss,et al.  Long-term potentiation of the perforant path in vivo is associated with increased glutamate release , 1982, Nature.

[2]  B. R. Sastry,et al.  Presynaptic change associated with long-term potentiation in hippocampus. , 1982, Life sciences.

[3]  R. Racine,et al.  Long-term potentiation phenomena in the rat limbic forebrain , 1983, Brain Research.

[4]  D. Marr.  A theory of cerebellar cortex , 1969, The Journal of physiology.

[5]  G. Lynch,et al.  Heterosynaptic depression: a postsynaptic correlate of long-term potentiation , 1977, Nature.

[6]  R. F. Thompson,et al.  Cerebellum: essential involvement in the classically conditioned eyelid response. , 1984, Science.

[7]  F A Miles,et al.  Long-term adaptive changes in primate vestibuloocular reflex. I. Behavioral observations. , 1980, Journal of neurophysiology.

[8]  M. Ito.  Cerebellar control of the vestibulo-ocular reflex--around the flocculus hypothesis. , 1982, Annual review of neuroscience.

[9]  T. Teyler,et al.  Long-term and short-term plasticity in the CA1, CA3, and dentate regions of the rat hippocampal slice , 1976, Brain Research.

[10]  G. A. Clark,et al.  Initial localization of the memory trace for a basic form of learning. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[11]  R. Douglas,et al.  Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus , 1975, Brain Research.

[12]  G. Jones,et al.  An adaptive neural model compatible with plastic changes induced in the human vestibulo-ocular reflex by prolonged optical reversal of vision , 1976, Brain Research.

[13]  T. Bliss,et al.  Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path , 1973, The Journal of physiology.

[14]  Timothy J. Teyler,et al.  Long-term potentiation as a candidate mnemonic device , 1984, Brain Research Reviews.

[15]  G. A. Clark,et al.  Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses , 1984, Brain Research.

[16]  P. Andersen,et al.  Specific long-lasting potentiation of synaptic transmission in hippocampal slices , 1977, Nature.

[17]  T. Teyler,et al.  Long-term potentiation. , 1987, Annual review of neuroscience.

[18]  P. Schwartzkroin,et al.  Long-lasting facilitation of a synaptic potential following tetanization in thein vitro hippocampal slice , 1975, Brain Research.

[19]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[20]  David A. McCormick,et al.  Ipsilateral cerebellar lesions prevent learning of the classically conditioned nictitating membrane/eyelid response , 1982, Brain Research.

[21]  F. A. Miles,et al.  Plasticity in the vestibulo-ocular reflex: a new hypothesis. , 1981, Annual review of neuroscience.

[22]  David A. McCormick,et al.  Superior cerebellar peduncle lesions selectively abolish the ipsilateral classically conditioned nictitating membrane/eyelid response of the rabbit , 1982, Brain Research.

[23]  F. A. Miles,et al.  Long-term adaptive changes in primate vestibuloocular reflex. II. Electrophysiological observations on semicircular canal primary afferents. , 1980, Journal of neurophysiology.

[24]  H. Galiana,et al.  A bilateral model for central neural pathways in vestibuloocular reflex. , 1984, Journal of neurophysiology.

[25]  G M Jones,et al.  A reevaluation of intervestibular nuclear coupling: its role in vestibular compensation. , 1984, Journal of neurophysiology.

[26]  M. Glickstein,et al.  THE EFFECTS OF CEREBELLAR LESIONS ON THE CONDITIONED NICTITATING-MEMBRANE RESPONSE OF THE RABBIT , 1983 .

[27]  J. Albus.  A Theory of Cerebellar Function , 1971 .