Temporal patterns of lipolytic regulators in adipose tissue after acute growth hormone exposure in human subjects: A randomized controlled crossover trial

[1]  J. Kopchick,et al.  Growth hormone controls lipolysis by regulation of FSP27 expression. , 2018, The Journal of endocrinology.

[2]  B. Stiles,et al.  PTEN: Tumor Suppressor and Metabolic Regulator , 2018, Front. Endocrinol..

[3]  M. Jensen,et al.  Human adipose tissue protein analyses using capillary western blot technology , 2018, Nutrition & Diabetes.

[4]  M. Bidlingmaier,et al.  Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade , 2017, The Journal of clinical endocrinology and metabolism.

[5]  L. Kenner,et al.  Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice , 2016, Diabetologia.

[6]  M. Vendelbo,et al.  Stress hormone release is a key component of the metabolic response to lipopolysaccharide: studies in hypopituitary and healthy subjects. , 2016, European journal of endocrinology.

[7]  N. Møller,et al.  Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial , 2016, PloS one.

[8]  J. Rungby,et al.  Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast. , 2016, American journal of physiology. Endocrinology and metabolism.

[9]  J. Schwartz,et al.  Growth hormone signaling pathways. , 2016, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[10]  M. Vendelbo,et al.  GH signaling in human adipose and muscle tissue during 'feast and famine': amplification of exercise stimulation following fasting compared to glucose administration. , 2015, European journal of endocrinology.

[11]  A. Juul,et al.  GH signaling in skeletal muscle and adipose tissue in healthy human subjects: impact of gender and age. , 2014, European journal of endocrinology.

[12]  N. Møller,et al.  Growth hormone signaling in muscle and adipose tissue of obese human subjects: associations with measures of body composition and interaction with resveratrol treatment. , 2014, The Journal of clinical endocrinology and metabolism.

[13]  J. Jørgensen,et al.  Kinetics and utilization of lipid sources during acute exercise and acipimox. , 2014, American journal of physiology. Endocrinology and metabolism.

[14]  N. Møller,et al.  Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease. , 2014, Journal of molecular endocrinology.

[15]  R. Zechner,et al.  Fat-specific Protein 27 (FSP27) Interacts with Adipose Triglyceride Lipase (ATGL) to Regulate Lipolysis and Insulin Sensitivity in Human Adipocytes* , 2014, The Journal of Biological Chemistry.

[16]  M. Woo,et al.  Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing , 2014, Diabetologia.

[17]  H. Pilegaard,et al.  Growth hormone‐induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity , 2014, Acta physiologica.

[18]  J. Kittilson,et al.  PKC and ERK mediate GH-stimulated lipolysis. , 2013, Journal of molecular endocrinology.

[19]  Side Liu,et al.  The Role of PTEN in Chronic Growth Hormone-Induced Hepatic Insulin Resistance , 2013, PloS one.

[20]  B. Sos,et al.  Disruption of JAK2 in Adipocytes Impairs Lipolysis and Improves Fatty Liver in Mice With Elevated GH , 2013, Molecular endocrinology.

[21]  M. Vendelbo,et al.  Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue. , 2011, The Journal of clinical endocrinology and metabolism.

[22]  M. Waters,et al.  GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism. , 2011, Endocrinology.

[23]  A. Chawla,et al.  Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes[S] , 2011, Journal of Lipid Research.

[24]  Xin Lu,et al.  The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. , 2010, Cell metabolism.

[25]  Niels Møller,et al.  Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. , 2009, Endocrine reviews.

[26]  J. Frystyk,et al.  Impact of fasting on growth hormone signaling and action in muscle and fat. , 2009, The Journal of clinical endocrinology and metabolism.

[27]  N. Møller,et al.  Growth hormone signaling in vivo in human muscle and adipose tissue: impact of insulin, substrate background, and growth hormone receptor blockade. , 2008, The Journal of clinical endocrinology and metabolism.

[28]  A. Chawla,et al.  Cidea is associated with lipid droplets and insulin sensitivity in humans , 2008, Proceedings of the National Academy of Sciences.

[29]  M. Waters,et al.  An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway , 2008, Nature Cell Biology.

[30]  D. Levy,et al.  JAK-STAT Signaling: From Interferons to Cytokines* , 2007, Journal of Biological Chemistry.

[31]  T. Sasaoka,et al.  Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity. , 2006, Pharmacology & therapeutics.

[32]  L. Gormsen,et al.  GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus. , 2006, American journal of physiology. Endocrinology and metabolism.

[33]  T. Jatkoe,et al.  The G0/G1 switch gene 2 is a novel PPAR target gene. , 2005, The Biochemical journal.

[34]  S. Tunaru,et al.  PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect , 2003, Nature Medicine.

[35]  N. Møller,et al.  Pharmacological antilipolysis restores insulin sensitivity during growth hormone exposure. , 2001, Diabetes.

[36]  E. Reiter,et al.  Growth hormone , 1993 .

[37]  J. Jørgensen,et al.  Regulation of lipoprotein lipase and hormone-sensitive lipase activity and gene expression in adipose and muscle tissue by growth hormone treatment during weight loss in obese patients. , 2000, Metabolism: clinical and experimental.

[38]  J. Olefsky,et al.  The Tumor Suppressor PTEN Negatively Regulates Insulin Signaling in 3T3-L1 Adipocytes* , 2000, The Journal of Biological Chemistry.

[39]  S. Bahouth,et al.  Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice. , 1999, Biochemical and biophysical research communications.

[40]  Michael P. Brown,et al.  Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses , 1998, Cell.

[41]  J. Schwartz,et al.  Growth hormone alters lipolysis and hormone-sensitive lipase activity in 3T3-F442A adipocytes. , 1991, Metabolism: clinical and experimental.

[42]  E. Ferrannini.  The theoretical bases of indirect calorimetry: a review. , 1988, Metabolism: clinical and experimental.

[43]  F. Matsuzaki,et al.  Growth hormone. 1. Physiologic aspects. , 1962, The New England journal of medicine.

[44]  M. Vendelbo,et al.  Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes. , 2019, American journal of physiology. Endocrinology and metabolism.

[45]  M. Vendelbo,et al.  Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study , 2016, Diabetologia.

[46]  V. Harris,et al.  Protein detection by Simple Western™ analysis. , 2015, Methods in molecular biology.

[47]  K. Alberti,et al.  Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. , 1990, The American journal of physiology.