We demonstrate a facile way of cross-linking hydrophobic perfluoropolyethers, PFPEs, with a series of hydrophilic poly(ethylene glycol)s, PEGs, to prepare a range of amphiphilic networks for use as fouling-release coatings. The PFPE matrix of the networks endows the coating with a low surface energy while the PEG is added to weaken fouling adhesion. It is therefore envisioned that the coating surfaces of these optically transparent and mechanically robust films will display hydrophobicity leading to nonfouling and fouling release characteristics. Two kinds of functionalized PEG oligomers have been cross-linked with reactive, dimethacryloxy-functionalized PFPE oligomers to form a range of amphiphilic networks: (i) a monomethacryloxy-functionalized PEG macromonomer (454 g/mol) (PEG454−MA) which was used to yield blends with flexible PEG chains on the surface as well as in bulk and (ii) a dimethacryloxy-functionalized PEG (550 g/mol) (PEG550−DMA) which results in PEG chains that are relatively more restricte...